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2024 | OriginalPaper | Buchkapitel

21. Postmenopausale Osteoporose und Osteoporose des Mannes über 50 Jahre

verfasst von : Bernhard Rintelen

Erschienen in: Rheumatologie aus der Praxis

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Die Osteoporose ist eine systemische Skeletterkrankung, die durch eine verminderte Knochenfestigkeit charakterisiert ist. Personen mit einer Osteoporose sind für ein erhöhtes Frakturrisiko prädisponiert [6]. Sie ist charakterisiert durch eine erniedrigte Knochendichte und gestörte Mikroarchitektur des Knochens. Dadurch bricht der Knochen leichter, oftmals schon durch ein niedrigenergetisches Trauma.
Literatur
1.
Zurück zum Zitat Beauchet O, Fantino B, Allali G, Muir SW, Montero-Odasso M, Annweiler C (2011) Timed up and go test and risk of falls in older adults: a systematic review. J Nutr Health Aging 15(10):933–938CrossRefPubMed Beauchet O, Fantino B, Allali G, Muir SW, Montero-Odasso M, Annweiler C (2011) Timed up and go test and risk of falls in older adults: a systematic review. J Nutr Health Aging 15(10):933–938CrossRefPubMed
2.
Zurück zum Zitat Black DM, Reid IR, Boonen S, Bucci-Rechtweg C, Cauley JA, Cosman F, Cummings SR, Hue TF, Lippuner K, Lakatos P, Leung PC, Man Z, Martinez RL, Tan M, Ruzycky ME, Su G, Eastell R (2012) The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT). J Bone Miner Res 27(2):243–254CrossRefPubMed Black DM, Reid IR, Boonen S, Bucci-Rechtweg C, Cauley JA, Cosman F, Cummings SR, Hue TF, Lippuner K, Lakatos P, Leung PC, Man Z, Martinez RL, Tan M, Ruzycky ME, Su G, Eastell R (2012) The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis: a randomized extension to the HORIZON-Pivotal Fracture Trial (PFT). J Bone Miner Res 27(2):243–254CrossRefPubMed
3.
Zurück zum Zitat Bone HG, Bolognese MA, Yuen CK, Kendler DL, Miller PD, Yang YC, Grazette L, San Martin J, Gallagher JC (2011) Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass. J Clin Endocrinol Metab 96(4):972–980CrossRefPubMed Bone HG, Bolognese MA, Yuen CK, Kendler DL, Miller PD, Yang YC, Grazette L, San Martin J, Gallagher JC (2011) Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass. J Clin Endocrinol Metab 96(4):972–980CrossRefPubMed
4.
Zurück zum Zitat Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S (2017) 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol 5(7):513–523CrossRefPubMed Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S (2017) 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol 5(7):513–523CrossRefPubMed
5.
Zurück zum Zitat Carey JJ, Buehring B (2018) Current imaging techniques in osteoporosis. Clin Exp Rheumatol 36 Suppl 114(5):115–126PubMed Carey JJ, Buehring B (2018) Current imaging techniques in osteoporosis. Clin Exp Rheumatol 36 Suppl 114(5):115–126PubMed
6.
Zurück zum Zitat Consensus Development Conference (1991) Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 90:107–110CrossRef Consensus Development Conference (1991) Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 90:107–110CrossRef
7.
Zurück zum Zitat Cranney A, Jamal SA, Tsang JF, Josse RG, Leslie WD (2007) Low bone mineral density and fracture burden in postmenopausal women. CMAJ 177(6):575–580CrossRefPubMedPubMedCentral Cranney A, Jamal SA, Tsang JF, Josse RG, Leslie WD (2007) Low bone mineral density and fracture burden in postmenopausal women. CMAJ 177(6):575–580CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Dimai HP, Johansson H, Harvey NC, Lorentzon M, Liu E, Vandenput L, Fahrleitner-Pammer A, Pietschmann P, Muschitz C, McCloskey EV, Kanis JA (2022) Osteoporosis treatment in Austria-assessment of FRAX-based intervention thresholds for high and very high fracture risk. Arch Osteoporos 17(1):141CrossRefPubMedPubMedCentral Dimai HP, Johansson H, Harvey NC, Lorentzon M, Liu E, Vandenput L, Fahrleitner-Pammer A, Pietschmann P, Muschitz C, McCloskey EV, Kanis JA (2022) Osteoporosis treatment in Austria-assessment of FRAX-based intervention thresholds for high and very high fracture risk. Arch Osteoporos 17(1):141CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Dimai HP, Muschitz C, Amrein K, Bauer R, Cejka D, Gasser RW, Gruber R, Haschka J, Hasenöhrl T, Kainberger F, Kerschan-Schindl K, Kocijan R, König J, Kroißenbrunner N, Kuchler U, Oberforcher C, Ott J, Pfeiler G, Pietschmann P, Puchwein P, Schmidt-Ilsinger A, Zwick RH, Fahrleitner-Pammer A (2024) Osteoporose – Definition, Risikoerfassung, Diagnose, Prävention und Therapie (Update 2024) : Leitlinie der Österreichischen Gesellschaft für Knochen- und Mineralstoffwechsel [Osteoporosis-Definition, risk assessment, diagnosis, prevention and treatment (update 2024) : Guidelines of the Austrian Society for Bone and Mineral Research]. Wien Klin Wochenschr. 2024(Suppl 16):599–668. German. https://doi.org/10.1007/s00508-024-02441-2. Epub 2024 Oct 2. PMID: 39356323. Dimai HP, Muschitz C, Amrein K, Bauer R, Cejka D, Gasser RW, Gruber R, Haschka J, Hasenöhrl T, Kainberger F, Kerschan-Schindl K, Kocijan R, König J, Kroißenbrunner N, Kuchler U, Oberforcher C, Ott J, Pfeiler G, Pietschmann P, Puchwein P, Schmidt-Ilsinger A, Zwick RH, Fahrleitner-Pammer A (2024) Osteoporose – Definition, Risikoerfassung, Diagnose, Prävention und Therapie (Update 2024) : Leitlinie der Österreichischen Gesellschaft für Knochen- und Mineralstoffwechsel [Osteoporosis-Definition, risk assessment, diagnosis, prevention and treatment (update 2024) : Guidelines of the Austrian Society for Bone and Mineral Research]. Wien Klin Wochenschr. 2024(Suppl 16):599–668. German. https://​doi.​org/​10.​1007/​s00508-024-02441-2. Epub 2024 Oct 2. PMID: 39356323.
11.
Zurück zum Zitat Elbers LPB, Raterman HG, Lems WF (2021) Bone mineral density loss and fracture risk after discontinuation of anti-osteoporotic drug treatment: a narrative review. Drugs 81(14):1645–1165CrossRefPubMedPubMedCentral Elbers LPB, Raterman HG, Lems WF (2021) Bone mineral density loss and fracture risk after discontinuation of anti-osteoporotic drug treatment: a narrative review. Drugs 81(14):1645–1165CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Eriksen EF, Lyles KW, Colón-Emeric CS, Pieper CF, Magaziner JS, Adachi JD, Hyldstrup L, Recknor C, Nordsletten L, Lavecchia C, Hu H, Boonen S, Mesenbrink P (2009) Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture. J Bone Miner Res 24(7):1308–1313CrossRefPubMedPubMedCentral Eriksen EF, Lyles KW, Colón-Emeric CS, Pieper CF, Magaziner JS, Adachi JD, Hyldstrup L, Recknor C, Nordsletten L, Lavecchia C, Hu H, Boonen S, Mesenbrink P (2009) Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture. J Bone Miner Res 24(7):1308–1313CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Gartlehner G, Patel SV, Reddy S, Rains C, Schwimmer M, Kahwati L (2022) Hormone therapy for the primary prevention of chronic conditions in postmenopausal persons: updated evidence report and systematic review for the US preventive services task force. JAMA 328(17):1747–1176CrossRefPubMed Gartlehner G, Patel SV, Reddy S, Rains C, Schwimmer M, Kahwati L (2022) Hormone therapy for the primary prevention of chronic conditions in postmenopausal persons: updated evidence report and systematic review for the US preventive services task force. JAMA 328(17):1747–1176CrossRefPubMed
15.
Zurück zum Zitat Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8(9):1137–1148CrossRefPubMed Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8(9):1137–1148CrossRefPubMed
16.
Zurück zum Zitat Gregson CL, Armstrong DJ, Bowden J, Cooper C, Edwards J, Gittoes NJL, Harvey N, Kanis J, Leyland S, Low R, McCloskey E, Moss K, Parker J, Paskins Z, Poole K, Reid DM, Stone M, Thomson J, Vine N, Compston J (2022) UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos 17(1):58CrossRefPubMedPubMedCentral Gregson CL, Armstrong DJ, Bowden J, Cooper C, Edwards J, Gittoes NJL, Harvey N, Kanis J, Leyland S, Low R, McCloskey E, Moss K, Parker J, Paskins Z, Poole K, Reid DM, Stone M, Thomson J, Vine N, Compston J (2022) UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos 17(1):58CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Hoffmann I, Shojaa M, Kohl M, von Stengel S, Becker C, Gosch M, Jakob F, Kerschan-Schindl K, Kladny B, Clausen J, Lange U, Middeldorf S, Peters S, Schoene D, Sieber C, Tholen R, Thomasius F, Bischoff-Ferrari HA, Uder M, Kemmler W (2022) Exercise reduces the number of overall and major osteoporotic fractures in adults. Does supervision make a difference? Systematic review and meta-analysis. J Bone Miner Res 37(11):2132–2148CrossRefPubMed Hoffmann I, Shojaa M, Kohl M, von Stengel S, Becker C, Gosch M, Jakob F, Kerschan-Schindl K, Kladny B, Clausen J, Lange U, Middeldorf S, Peters S, Schoene D, Sieber C, Tholen R, Thomasius F, Bischoff-Ferrari HA, Uder M, Kemmler W (2022) Exercise reduces the number of overall and major osteoporotic fractures in adults. Does supervision make a difference? Systematic review and meta-analysis. J Bone Miner Res 37(11):2132–2148CrossRefPubMed
19.
Zurück zum Zitat Kanis JA et al (2011) Guidance for the adjustment of FRAX according to the dose of glucocorticoids. Osteoporos Int 22(3):809–816CrossRefPubMed Kanis JA et al (2011) Guidance for the adjustment of FRAX according to the dose of glucocorticoids. Osteoporos Int 22(3):809–816CrossRefPubMed
20.
Zurück zum Zitat Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, Oden A, Zethraeus N, Pfleger B, Khaltaev N (2005) Assessment of fracture risk. Osteoporos Int 16(6):581–589CrossRefPubMed Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, Oden A, Zethraeus N, Pfleger B, Khaltaev N (2005) Assessment of fracture risk. Osteoporos Int 16(6):581–589CrossRefPubMed
21.
Zurück zum Zitat Kanis JA, Johansson H, Oden A, Johnell O, de Laet C, Melton LJ III, Tenenhouse A, Reeve J, Silman AJ, Pols HA, Eisman JA, McCloskey EV, Mellstrom D (2004) A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res 19(6):893–899CrossRefPubMed Kanis JA, Johansson H, Oden A, Johnell O, de Laet C, Melton LJ III, Tenenhouse A, Reeve J, Silman AJ, Pols HA, Eisman JA, McCloskey EV, Mellstrom D (2004) A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res 19(6):893–899CrossRefPubMed
22.
Zurück zum Zitat Kanis JA, Norton N, Harvey NC, Jacobson T, Johansson H, Lorentzon M, McCloskey EV, Willers C, Borgström F (2021) SCOPE 2021: a new scorecard for osteoporosis in Europe. Arch Osteoporos 16(1):82CrossRefPubMedPubMedCentral Kanis JA, Norton N, Harvey NC, Jacobson T, Johansson H, Lorentzon M, McCloskey EV, Willers C, Borgström F (2021) SCOPE 2021: a new scorecard for osteoporosis in Europe. Arch Osteoporos 16(1):82CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Kantor SM, Ossa KS, Hoshaw-Woodard SL, Lemeshow S (2004) Height loss and osteoporosis of the hip. J Clin Densitom 7(1):65–70CrossRefPubMed Kantor SM, Ossa KS, Hoshaw-Woodard SL, Lemeshow S (2004) Height loss and osteoporosis of the hip. J Clin Densitom 7(1):65–70CrossRefPubMed
24.
Zurück zum Zitat LeBoff MS, Greenspan SL, Insogna KL, Lewiecki EM, Saag KG, Singer AJ, Siris ES (2022) The clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int 33(10):2049–2102CrossRefPubMedPubMedCentral LeBoff MS, Greenspan SL, Insogna KL, Lewiecki EM, Saag KG, Singer AJ, Siris ES (2022) The clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int 33(10):2049–2102CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Malle O, Borgstroem F, Fahrleitner-Pammer A, Svedbom A, Dimai SV, Dimai HP (2021) Mind the gap: Incidence of osteoporosis treatment after an osteoporotic fracture – results of the Austrian branch of the International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS). Bone 142:115071CrossRefPubMed Malle O, Borgstroem F, Fahrleitner-Pammer A, Svedbom A, Dimai SV, Dimai HP (2021) Mind the gap: Incidence of osteoporosis treatment after an osteoporotic fracture – results of the Austrian branch of the International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS). Bone 142:115071CrossRefPubMed
26.
Zurück zum Zitat McCloskey E, Rathi J, Heijmans S, Blagden M, Cortet B, Czerwinski E, Hadji P, Payer J, Palmer K, Stad R, O'Kelly J, Papapoulos S (2021) The osteoporosis treatment gap in patients at risk of fracture in European primary care: a multi-country cross-sectional observational study. Osteoporos Int 32(2):251–259CrossRefPubMed McCloskey E, Rathi J, Heijmans S, Blagden M, Cortet B, Czerwinski E, Hadji P, Payer J, Palmer K, Stad R, O'Kelly J, Papapoulos S (2021) The osteoporosis treatment gap in patients at risk of fracture in European primary care: a multi-country cross-sectional observational study. Osteoporos Int 32(2):251–259CrossRefPubMed
27.
Zurück zum Zitat Muschitz C, Hummer M, Grillari J, Hlava A, Birner AH, Hemetsberger M, Dimai HP (2022) Epidemiology and economic burden of fragility fractures in Austria. Osteoporos Int 33(3):637–647CrossRefPubMed Muschitz C, Hummer M, Grillari J, Hlava A, Birner AH, Hemetsberger M, Dimai HP (2022) Epidemiology and economic burden of fragility fractures in Austria. Osteoporos Int 33(3):637–647CrossRefPubMed
28.
Zurück zum Zitat Nayak S, Greenspan SL (2019) A systematic review and meta-analysis of the effect of bisphosphonate drug holidays on bone mineral density and osteoporotic fracture risk. Osteoporos Int 30(4):705–720CrossRefPubMedPubMedCentral Nayak S, Greenspan SL (2019) A systematic review and meta-analysis of the effect of bisphosphonate drug holidays on bone mineral density and osteoporotic fracture risk. Osteoporos Int 30(4):705–720CrossRefPubMedPubMedCentral
29.
Zurück zum Zitat Nevitt MC, Cummings SR, Stone KL, Palermo L, Black DM, Bauer DC, Genant HK, Hochberg MC, Ensrud KE, Hillier TA, Cauley JA (2005) Risk factors for a first-incident radiographic vertebral fracture in women > or = 65 years of age: the study of osteoporotic fractures. J Bone Miner Res 20(1):131–140PubMed Nevitt MC, Cummings SR, Stone KL, Palermo L, Black DM, Bauer DC, Genant HK, Hochberg MC, Ensrud KE, Hillier TA, Cauley JA (2005) Risk factors for a first-incident radiographic vertebral fracture in women > or = 65 years of age: the study of osteoporotic fractures. J Bone Miner Res 20(1):131–140PubMed
30.
Zurück zum Zitat Rodriguez AJ, Fink HA, Mirigian L, Guañabens N, Eastell R, Akesson K, Bauer DC, Ebeling PR (2017) Pain, quality of life, and safety outcomes of kyphoplasty for vertebral compression fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 32(9):1935–1944CrossRefPubMed Rodriguez AJ, Fink HA, Mirigian L, Guañabens N, Eastell R, Akesson K, Bauer DC, Ebeling PR (2017) Pain, quality of life, and safety outcomes of kyphoplasty for vertebral compression fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 32(9):1935–1944CrossRefPubMed
31.
Zurück zum Zitat Ryg J, Rejnmark L, Overgaard S, Brixen K, Vestergaard P (2009) Hip fracture patients at risk of second hip fracture: a nationwide population-based cohort study of 169,145 cases during 1977–2001. J Bone Miner Res 24(7):1299–1307CrossRefPubMed Ryg J, Rejnmark L, Overgaard S, Brixen K, Vestergaard P (2009) Hip fracture patients at risk of second hip fracture: a nationwide population-based cohort study of 169,145 cases during 1977–2001. J Bone Miner Res 24(7):1299–1307CrossRefPubMed
32.
Zurück zum Zitat Salonen L, Kivelä SL (2012) Eye diseases and impaired vision as possible risk factors for recurrent falls in the aged: a systematic review. Curr Gerontol Geriatr Res 2012:271481CrossRefPubMedPubMedCentral Salonen L, Kivelä SL (2012) Eye diseases and impaired vision as possible risk factors for recurrent falls in the aged: a systematic review. Curr Gerontol Geriatr Res 2012:271481CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Schwartz AV, Bauer DC, Cummings SR, Cauley JA, Ensrud KE, Palermo L, Wallace RB, Hochberg MC, Feldstein AC, Lombardi A, Black DM, FLEX Research Group (2010) Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: the FLEX trial. J Bone Miner Res 25(5):976–982CrossRefPubMed Schwartz AV, Bauer DC, Cummings SR, Cauley JA, Ensrud KE, Palermo L, Wallace RB, Hochberg MC, Feldstein AC, Lombardi A, Black DM, FLEX Research Group (2010) Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: the FLEX trial. J Bone Miner Res 25(5):976–982CrossRefPubMed
34.
Zurück zum Zitat Siehe Fachinformation der Präparate (Austria Codes Fachinformation, Apothekerverlag, Erscheinungsdatum 01.09.2024) Siehe Fachinformation der Präparate (Austria Codes Fachinformation, Apothekerverlag, Erscheinungsdatum 01.09.2024)
35.
Zurück zum Zitat Vellucci R, Terenzi R, Kanis JA, Kress HG, Mediati RD, Reginster JY, Rizzoli R, Brandi ML (2018) Understanding osteoporotic pain and its pharmacological treatment. Osteoporos Int 29(7):1477–1491CrossRefPubMed Vellucci R, Terenzi R, Kanis JA, Kress HG, Mediati RD, Reginster JY, Rizzoli R, Brandi ML (2018) Understanding osteoporotic pain and its pharmacological treatment. Osteoporos Int 29(7):1477–1491CrossRefPubMed
36.
Zurück zum Zitat Viswanathan M, Reddy S, Berkman N, Cullen K, Middleton JC, Nicholson WK, Kahwati LC (2018) Screening to prevent osteoporotic fractures: updated evidence report and systematic review for the US preventive services task force. JAMA 319(24):2532–2551CrossRefPubMed Viswanathan M, Reddy S, Berkman N, Cullen K, Middleton JC, Nicholson WK, Kahwati LC (2018) Screening to prevent osteoporotic fractures: updated evidence report and systematic review for the US preventive services task force. JAMA 319(24):2532–2551CrossRefPubMed
37.
Zurück zum Zitat Wilson N, Hurkmans E, Adams J, Bakkers M, Balážová P, Baxter M, Blavnsfeldt AB, Briot K, Chiari C, Cooper C, Dragoi R, Gäbler G, Lems W, Mosor E, Pais S, Simon C, Studenic P, Tilley S, de la Torre J, Stamm TA (2020) Prevention and management of osteoporotic fractures by non-physician health professionals: a systematic literature review to inform EULAR points to consider. RMD Open 6(1):e001143CrossRefPubMedPubMedCentral Wilson N, Hurkmans E, Adams J, Bakkers M, Balážová P, Baxter M, Blavnsfeldt AB, Briot K, Chiari C, Cooper C, Dragoi R, Gäbler G, Lems W, Mosor E, Pais S, Simon C, Studenic P, Tilley S, de la Torre J, Stamm TA (2020) Prevention and management of osteoporotic fractures by non-physician health professionals: a systematic literature review to inform EULAR points to consider. RMD Open 6(1):e001143CrossRefPubMedPubMedCentral
38.
Zurück zum Zitat World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group [meeting held in Rome from 22 to 25 June 1992]. World Health Organization World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group [meeting held in Rome from 22 to 25 June 1992]. World Health Organization
Metadaten
Titel
Postmenopausale Osteoporose und Osteoporose des Mannes über 50 Jahre
verfasst von
Bernhard Rintelen
Copyright-Jahr
2024
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-69693-4_21