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2016 | OriginalPaper | Buchkapitel

46. Stammzellen und deren Bedeutung in der Geburtshilfe

verfasst von : Anna Margareta Wagner, Daniel Surbek

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Hämatopoietische Stammzellen werden mittlerweile erfolgreich bei einer Vielzahl von malignen und nicht malignen Krankheiten transplantiert, in erster Linie Leukämien, schwere Anämien, schwere Immundefizienzen und angeborene Stoffwechselstörungen. Nabelschnurblut erweitert die Möglichkeit für die Gewinnung von hämatopoietischen Stammzellen, v. a. für Patienten, die sonst keinen passenden Spender finden können.

Die Wahrscheinlichkeit, dass ein anonym gespendetes (allogenes) Nabelschnurbluttransplantat von einer öffentlichen Bank gebraucht und transplantiert wird, ist mehr als 100× größer als die Verwendung der eigenen (autologen) hämatopoietischen Nabelschnurblutstammzellen aus einer privaten Bank.

Die Aufgabe des Arztes im Zusammenhang mit der Entscheidung für eine Nabelschnurspende beinhaltet eine ausführliche, möglichst objektive Aufklärung. Grundlagen dazu bilden Empfehlungen nationaler und internationaler Fachgesellschaften.

Vorheriges Kapitel Versorgung des Neugeborenen

Nächstes Kapitel Wochenbett

ACOG (2012) Timing of umbilical cord clamping after birth; Number 543, December 2012, http://www.acog.org/Resources-And-Publications/Committee-Opinions/Committee-on-Obstetric-Practice/Timing-of-Umbilical-Cord-Clamping-After-Birth

Backhaus K (2010) Qualitätsbeeinflussende Faktoren der Nabelschnurblutspende. Untersuchungen von 1500 Nabelschnurblutpräparaten der Erlanger Nabelschnurblutbank. Diss, Univ Erlangen download unter https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/1066

Barker JN, Krepski TP, DeFor TE, Davies SM, Wagner JE, Weisdorf DJ (2002) Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow. Biol Blood Marrow Transplant 8(5):257–260CrossRefPubMed

Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, McGlave PB, Miller JS, Verfaillie CM, Wagner JE (2005) Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 105:1343–1347CrossRefPubMed

Beuzard Y, Vainchenker W, Testa U et al (1979) Fetal to adult hemoglobin switching in cultures of early erythroid precursors from human fetuses and neonates. Am J Hematol 7:207–218CrossRefPubMed

Breymann C, Schmidt D, Hoerstrup SP (2006) Umbilical cord cells as a source of cardiovascular tissue engineering. Rev Stem Cell Rev 2(2):87–92CrossRefPubMed

Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID (2010) Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 16:232–236CrossRefPubMedPubMedCentral

De Lima M, Robinson S, McMannis J, Alousi AM, Saliba RM, Munsell M et al (2010) Mesenchymal stem cell (msc) based cord blood (CB) expansion (Exp) leads to rapid engraftment of platelets and neutrophils. Blood (ASH Annu Meeting Abstracts) 116(21):362

Eapen M, Rubinstein P, Zhang MJ, Stevens C, Kurtzberg J, Scaradavou A, Loberiza FR, Champlin RE, Klein JP, Horowitz MM, Wagner JE (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 369:1947–1954CrossRefPubMed

Ferreira E, Pasternak J, Bacal N, de Campos Guerra JC, Watanabe FM (1999) Autologous cord blood transplantation. Bone Marrow Transplant 24:1041CrossRefPubMed

Fruchtman SM, Hurlet A, Dracker R, Isola L, Goldman B, Schneider BL, Emre S (2004) The successful treatment of severe aplastic anemia with autologous cord blood transplantation. Biol Blood Marrow Transplant 10:741–742CrossRefPubMed

Gluckman E, Rocha V (2009) Cord blood transplantation: state of the art. Haematologica 94(4):451–454CrossRefPubMedPubMedCentral

Gluckman E, Broxmeyer HE, Auerbach AD, Friedman HS, Douglas GW, Devergie A et al (1989) Hematopoietic reconsitution in a patient with Fanconi’s anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 321:1174–1178CrossRefPubMed

Gluckman E, Rocha V, Arcese W, Michel G, Sanz G, Chan KW, Takahashi TA, Ortega J, Filipovich A, Locatelli F, Asano S, Fagioli F, Vowels M, Sirvent A, Laporte JP, Tiedemann K, Amadori S, Abecassis M, Bordigoni P, Diez B, Shaw PJ, Vora A, Caniglia M, Garnier F, Ionescu I, Garcia J, Koegler G, Rebulla P, Chevret S, Group E (2004) Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol 32(4):397–407CrossRefPubMed

Goecke TW, Backhaus K, Zingsem J, Weisbach V, Beckmann MW, Engel JWM (2008) Einflussfaktoren der Nabelschnurblutspende – Eine Auswertung von 1500 Präparaten. Geburtsh Frauenheilkd 68: PO_Geb_03_12 doi: 10.1055/s-0028-1089092

Gratwohl A, Passweg J, Kühne T, Tyndall A, Holzgreve W, Skoda R (2002) Hämatopoietische Stammzelltransplantation. Schweiz Med Forum 25:597–606

Grewal SS, Barker JN, Davies SM, Wagner JE (2003) Unrelated donor hematopoietic stem cell transplantation: marrow or umbilical cord? Blood 101:4233–4444CrossRefPubMed

Haller MJ, Wasserfall CH, Schatz DA et al (2013) Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin d supplementation for C-peptide preservation in children with type 1 diabetes. Biol Blood Marrow Transplant 19(7):1126–1129CrossRefPubMed

Hofmeister CC, Zhang J, Knight KL, Le P, Stiff PJ (2007) Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche. Bone Marrow Transplant 39(1):11–23CrossRefPubMed

Hwang WY, Samuel M, Tan D, Koh LP, Lim W, Linn YC (2007) A meta-analysis of unrelated donor umbilical cord blood transplantation versus unrelated donor bone marrow transplantation in adult and pediatric patients. Biol Blood Marrow Transplant 13(4):444–453CrossRefPubMed

Ilic D, Miere C, Lazic E (2012) Umbilical cord blood stem cells: clinical trials in non-hematological disorders. Br Med Bull 102:43–57CrossRefPubMed

Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M (2000) Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6:1229–1234CrossRefPubMed

Manegold G, Meyer-Nonard S, Tichelli A, Pauli D, Holzgreve W, Troeger C (2009) Cesarean section due to fetal distress increases the number of stem cells in umbilical cord blood. Transfusion 49(2):388–389CrossRef

Mancinelli F, Tamburini A, Spagoli A, Malerba C, Suppo G, Lasorella R, de Fabitiis P, Calugi A (2006) Optimizing umbilical cord blood collection: impact of obstetric factors versus quality of cord blood units. Transplant Proc 38(4):1174–1176CrossRefPubMed

McGuckin CP, Basford C, Hanger K (2007) Cord blood revelations: the importance of being a first born girl, big, on time and to a young mother. Institute of Human Genetics. Early Hum Dev 83(12):733–741CrossRefPubMed

Nietfeld JJ, Pasquini MC, Logan BR, Verter F, Horowitz MM (2008) Lifetime probabilities of hematopoietic stem cell transplantation in the U.S. Biol Blood Marrow Transplant 14(3):316–322CrossRefPubMedPubMedCentral

Norkin M, Lazarus HM, Wingard JR (2013) Umbilical cord blood graft enhancement strategies: has the time come to move these into the clinic? Bone Marrow Transplant 48(7):884–889CrossRefPubMed

Portmann-Lanz CB, Schoeberlein A, Portmann R, Mohr S, Rollini P, Sager R, Surbek DV (2010) Turning placenta into brain: placental mesenchymal stem cells differentiate into neurons and oligodendrocytes. Am J Obstet Gynecol 202(3):294.e1–294.e11. doi:10.1016/j.ajog.2009.10.893 [Epub 2010 Jan 8]

Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, Bosi A, Jacobsen N, Ruutu T, de Lima M, Finke J, Frassoni F, Gluckman E, Acute Leukemia Working Party of European Blood and Marrow Transplant Group; Eurocord-Netcord Registry (2004) Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 351(22):2276–2285

Rovo A, Gratwohl A (2008) Plasticity after allogeneic hematopoietic stem cell transplantation. Biol Chem 389:825–836CrossRefPubMed

Rubinstein P (2006) Why cord blood? Hum Immunol 67:398–404CrossRefPubMed

Schoeberlein A, Müller M, Reinhart U, Sager R, Messerli M, Surbek DV (2011) Homing of placental-derived mesenchymal stem cells after perinatal intracerebral transplantation in a rat model. Am J Obstet Gynecol 277:e1–e6

Sullivan MJ (2008) Banking on cord blood stem cells. Nat Rev Cancer 8:555–563CrossRefPubMed

Surbek DV, Holzgreve W, Jansen W, Heim D, Garritsen H, Nissen C, Wodnar-Filipowicz A (1998) Quantitative immunophenotypic characterization, cryopreservation, and enrichment of second and third trimester human fetal cord blood hematopoietic stem cells (progenitor cells). Am J Obstet Gynecol 179:1228–1233CrossRefPubMed

Surbek DV, Visca E, Steinmann C, Tichelli A, Schatt S, Hahn S, Gratwohl A, Holzgreve W (2000) Umbilical cord blood collection before placental delivery during cesarean section increases cord blood volume and nucleated cell number available for transplantation. Am J Obstet Gynecol 183:218–221CrossRefPubMed

van de Ven C, Collins D, Bradley MB, Morris E, Cairo MS (2007) The potential of umbilical cord blood multipotent stem cells for nonhematopoietic tissue and cell regeneration. Exp Hematol 35:1753–1765CrossRefPubMed

van Rood JJ, Oudshoorn M (2008) Eleven million donors in bone marrow donors worldwide! Time for reassessment? Bone Marrow Transplant 41:1–9CrossRefPubMed

Wagner AM, Krenger W, Suter E, Ben Hassem D, Surbek DV (2013) High acceptance rate of hybrid allogeneic-autologous umbilical cord blood banking among actual and potential Swiss donors. Transfusion 53(7):1510–1519CrossRefPubMed

Wagner AM, Surbek DV (2009) Umbilical cord mesenchymal stem cells: impact of gestational and morphometric factors. Reprod Sci 16:742

Weber B, Emmert MY, Hoerstrup SP et al (2012a) Prenatally engineered autologous amniotic fluid stem cell-based heart valves in the fetal circulation. Biomaterials 33(16):4031–4043CrossRefPubMed

Weber B, Emmert MY, Hoerstrup SP (2012b) Stem cells for heart valve regeneration. Swiss Med Wkly142:w13622

Wynn R (2011) Stem cell transplantation in inherited metabolic disorders. Hematology Am Soc Hematol Educ Program 2011:285–291PubMed

Yao AC, Moinian M, Lind J (1969) Distribution of blood between infant and placenta after birth. Lancet: 2(7626):871–873CrossRef

Titel: Stammzellen und deren Bedeutung in der Geburtshilfe
verfasst von: Anna Margareta Wagner
Daniel Surbek
Verlag: Springer Berlin Heidelberg
Buch: Die Geburtshilfe
Print ISBN: 978-3-662-45063-5

Electronic ISBN: 978-3-662-45064-2

Copyright-Jahr: 2016
DOI: https://doi.org/10.1007/978-3-662-45064-2_45

Springerpflege

Zusammenfassung

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