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Erschienen in:

2018 | OriginalPaper | Buchkapitel

2. Immunologie der fetomaternalen Grenze

verfasst von : Udo R. Markert, Johanna Seitz, Theresa Hofmann, Juliane Götze, Sebastian Schamberger

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Die Schwangerschaft stellt die einzigartige Situation dar, in der zwei allogene Organismen, Mutter und Fetus, ohne Abstoßungsreaktionen in Symbiose zusammenleben. Die Plazenta bildet dabei den größten Teil der Grenzfläche und ist somit von besonderer immunologischer Bedeutung. Verschiedenste plazentare Faktoren, großenteils von Trophoblastzellen produziert und sezerniert, induzieren eine weitgehend spezifische Toleranz gegenüber dem Embryo oder Fetus, ohne dabei die eigentlichen Funktionen des Immunsystems grundlegend zu verändern. Störungen dieser Toleranz können zu allen Zeitpunkten den Schwangerschaftsverlauf beeinträchtigen oder eine Schwangerschaft gar nicht erst zustande kommen lassen. Immunologische Parameter haben daher das Potenzial, als diagnostische Marker und für neue Behandlungsstrategien genutzt zu werden. Das vorliegende Kapitel soll einen groben Eindruck in die komplexe Thematik vermitteln.

Vorheriges Kapitel Plazentaentwicklung mit histologischen Aspekten

Nächstes Kapitel Plazentamorphologie

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Titel: Immunologie der fetomaternalen Grenze
verfasst von: Udo R. Markert
Johanna Seitz
Theresa Hofmann
Juliane Götze
Sebastian Schamberger
Verlag: Springer Berlin Heidelberg
Buch: Die Plazenta
Print ISBN: 978-3-662-55621-4

Electronic ISBN: 978-3-662-55622-1

Copyright-Jahr: 2018
DOI: https://doi.org/10.1007/978-3-662-55622-1_2

Springerpflege

Zusammenfassung

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