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Open Access 01.12.2025 | Research

Effectiveness of a blended (distance and in-person) simulation education program on advanced cardiac life support for nursing students using the PARTNER model

verfasst von: Miyoung Kang, Eunju Lee

Erschienen in: BMC Nursing | Ausgabe 1/2025

Abstract

Background

The incidence of acute cardiac arrest is increasing and is directly linked to patient survival, highlighting the critical role of nurses. Advanced nursing skills for cardiac arrest patients, such as self-directed pre-learning applied to various clinical situations, require a systematic blended learning approach to integrate knowledge and enhance clinical performance through face-to-face practice. The purpose of this study is to evaluate the effectiveness of a blended simulation education program for Advanced Cardiac Life Support (ACLS) using the PARTNER model.

Methods

A nonequivalent control group pretest-posttest design with a time-lagged approach was used to collect data from 34 third-year nursing students. The experimental group(n = 17) received a 480-minute blended simulation education program based on the PARTNER model and flipped learning, while the control group(n = 17) participated in a 480-minute traditional simulation education program.

Results

The study found that knowledge, confidence, performance in advanced cardiac life support, and clinical performance ability were effectively enhanced, although no significant effect was observed in learning satisfaction.

Conclusions

The program provides a new direction in applying blended simulation using the PARTNER model for advanced cardiac life support nursing education, ultimately contributing to the training of nurses competent in advanced cardiac life support.
Hinweise

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Introduction

Due to recent increases in population aging, meat-centric diets, and high stress, the incidence of acute cardiac arrest is rising. Approximately 80% of patients with acute cardiac arrest die within one hour, making it a life-threatening emergency situation [1, 2]. Nursing students often do not encounter cardiac arrest patients during clinical training, and it is challenging for them to participate in such critical situations when they do occur [3, 4]. Additionally, cardiac arrests in hospitals often arise from complex issues in patients, necessitating specialized education in advanced cardiopulmonary resuscitation including drug administration according to ECG findings, airway management, and correction of issues causing the arrest [5, 6]. However, specialized CPR training is only provided in some nursing schools, and is generally characterized by instructor-led theoretical education followed immediately by practical training, which is often inadequate [7].
Due to the unpredictability of clinical situations, theoretical knowledge acquired in classroom settings often fails to translate into immediate practical application without integration with practical skills [7]. Therefore, scenario-based simulation training reflecting various clinical situations is essential, though understanding complex scenarios can be challenging without adequate prebriefing [8]. A systematic blended learning approach that combines self-directed prebriefing with hands-on practice is crucial for integrating knowledge and enhancing clinical performance in managing emergencies like cardiac arrest [9]. Blended learning is an instructional approach that combines two or more learning methods, integrating both online (asynchronous) and face-to-face (synchronous) sessions. It is emphasized as an important and systematic practice for learner-centered education [10].
Despite efforts to promote self-directed learning through resources and instructional videos, merely providing learning materials does not necessarily enhance students’ motivation or ensure diligent study [11]. Web-based simulations after theoretical learning can provide a pseudo-experience similar to real clinical scenarios, enabling autonomous learning outside the classroom and better preparation for face-to-face practical sessions [12].
In face-to-face practical training, especially for advanced professional nursing skills like those required for cardiac arrest, scenario-based simulation training is necessary to link previously learned knowledge through systematic learning processes [13]. However, previous studies often comprised only brief simulations following group discussions or simple practice, which were insufficient for enhancing clinical performance [14].
Flipped learning, where students engage in theoretical study outside the classroom before engaging in case-based collaborative learning inside the classroom facilitated by instructor coaching, enhances problem-solving skills [15, 16]. The PARTNER model exemplifies a learner-centered approach to flipped learning, systematically structured in seven stages, starting with autonomous pre-class study to integrate knowledge, followed by collaborative learning centered around clinical scenarios in the classroom [14, 17]. Through team collaboration and case-based discussions, this model facilitates reflective contemplation for addressing complex cardiac arrest scenarios, thereby enhancing knowledge, confidence, and problem-solving abilities [18]. However, prior studies utilizing the PARTNER model have focused only on simple nursing techniques and theoretical education, with limited research on the effects of blended simulation training for advanced cardiopulmonary resuscitation. Thus, this study aims to apply a PARTNER model-based blended simulation training program in advanced cardiopulmonary resuscitation to nursing students to evaluate its effectiveness.

Purpose

The purpose of this study is to compare the effectiveness of a blended simulation-based Advanced Cardiovascular Life Support (ACLS) education program utilizing the PARTNER model with traditional simulation education. This study aims to assess the effects of the program on nursing students’ ACLS knowledge, ACLS confidence, ACLS performance, clinical competence, and learning satisfaction.

Methods

Design

This study is a quasi-experimental research with a non-equivalent control group pretest-posttest design to assess the impact of the PARTNER model-based ACLS blended simulation training program on ACLS knowledge, confidence, performance, clinical competence, and learning satisfaction among nursing students. Figure 1 schematizes the overall flow of this study.

Participants

Participants were all third-year nursing students at K University, who voluntarily participated after obtaining approval from the head of their department. Students who had received ACLS simulation training from a professional institution within the last six months and obtained a certification were excluded based on the criteria from previous research [19]. Based on previous studies related to ACLS among nursing students [20] and studies on effect sizes [21], the necessary sample size was calculated using G*Power 3.1 for a medium effect size of 0.25, a power (1-β) of 0.80, and a significance level (α) of 0.05 for Repeated Measures ANOVA. Each group required 17 participants, totaling 34; however, considering a dropout rate of 20% from previous research [22], 22 participants were assigned to each group, totaling 44. Data collection was conducted from November 4, 2022, to December 30, 2022, in the simulation lab and debriefing room at the College of Nursing at K University. With dropouts accounted for, the final analysis included 17 participants in each group, totaling 34.

Measures

Instruments used to measure the effects were utilized with permission obtained via email and text messages from the developers or adaptors.

ACLS knowledge

ACLS knowledge was measured using an instrument developed by Chae, M. J. specifically for assessing knowledge in ACLS [23]. The total score was out of 20 points, with higher scores indicating greater knowledge. The content validity index (CVI) at the time of tool development was 0.80, and the reliability in this study measured by Kuder-Richardson Formula 20 (KR20) was 0.99.

ACLS confidence

ACLS confidence was measured using a tool developed by Chae, M. J. to assess confidence in performing ACLS [23]. It consisted of 10 items on a Likert scale of 0 to 10 points, where 0 meant ‘not at all’ and 10 meant ‘very much so’; higher scores indicated greater confidence. The reliability at the time of tool development was Cronbach’s α = 0.85, and in this study, it was 0.84.

ACLS performance

ACLS performance was measured using an instrument developed by the researcher based on the 2020 Korean ACLS guidelines [24]. The evaluators directly measured the ACLS performance of students using this tool. Validity was confirmed through consultations with one emergency medicine professor, two nurses with over ten years of experience in the emergency department, and two nursing professors. The content validity index (CVI) was 0.99, and the reliability in this study was Cronbach’s α = 0.81.

Clinical competence

Clinical competence was measured using an instrument initially developed by Lee, W. H., et al., which was modified and supplemented by Choi, M. S. to include 20 items specifically needed for ACLS from the original 45 items [25, 26]. It used a Likert scale from 1 (‘not at all’) to 5 (‘very well’), with higher scores indicating greater competence. The validity of the tool used in this study was confirmed by the same panel as for ACLS performance, and the content validity index (CVI) was 0.97; the reliability in previous research by Choi, M. S. was Cronbach’s α = 0.92, and in this study, it was 0.84 [26].

Learning satisfaction

Learning satisfaction was measured using an instrument initially developed by Lee, E. K. and modified by Sung, G. Y [27, 28]. It used a Likert scale from 1 (‘not at all’) to 5 (‘very much so’), with higher scores indicating greater satisfaction. The reliability of the learning satisfaction tool in the research by Sung, G. Y. was Cronbach’s α = 0.79, and in this study, it was 0.86.

Data collection

Pre-test

The pre-test involved surveying participants prior to the intervention to assess general characteristics, advanced cardiac life support knowledge, confidence, and clinical competence.

Intervention

The intervention for the experimental group was based on the PARTNER model developed by Choi and Kim from the flipped classroom structure by Bergmann and Sams [15, 16]. The program was structured into a seven-step process over two weeks totaling 480 min. The steps included pre-class preparation, pre-learning assessment, relevance (pre-learning linkage), collaborative learning, key summary lectures, evaluation, and post-class reflection(Fig. 1).

Experimental group’s intervention: blended simulation training program using the PARTNER model

The first step, Preparation, involved providing study materials for preview, including orientation, video lectures produced by the researcher, and web-based simulation training. The video lectures covered topics based on the 2020 ACLS Guidelines including cardiac arrest rhythms, advanced cardiac life support algorithms, airway management, defibrillation, emergency pharmacology, and return of spontaneous circulation [29]. The lectures lasted were available for the experimental group to view freely over a two-week period. The web-based simulation training utilized a scenario (Carl Shapiro) that included cardiac arrest, available for one week [30].
The second step was the pre-learning Assessment, where learners self-assessed their understanding of the concepts covered in the video lectures through a 10-item post-quiz using Google Forms.
The third step, Relevance, linked pre-class learning with problem-solving content to be addressed in cooperative learning, based on the pre-learned materials [16]. This phase included orientation, review of ACLS algorithms, case-based group discussions, practice with airway devices and defibrillators, and pre-briefing.
The fourth step involved Team Activities aimed at solving common problems through social interaction among team members [16]. The simulation training program for cooperative learning was designed to include a simulation that matched the learners’ level and learning objectives, included high-fidelity simulation settings, clinically similar scenarios, and an efficient simulation learning structure proposed by Jeffries, including, time setting, analysis and management of abnormal ECG Rhythms, patient simulator setting, expected interventions, and clues for scenario flow and debriefing [31].
The implementation of cooperative learning was conducted in the sequence of scenario planning, high-fidelity simulation training, and debriefing. Scenario planning is a management technique that involves developing various potential future scenarios and establishing strategic alternatives for each scenario in advance. In this study, students were instructed to watch a video of a good case of professional cardiopulmonary. resuscitation in Korea. Subsequently, they were required to write a scenario script beforehand and to plan within their teams for specific roles (leader, chest compression, artificial respiration, EKG monitoring and defibrillator operation, medication administration, documentation, etc.) and to prepare a plan for executing the scenario [32, 33].
High-fidelity simulation training utilized an adult simulator (SimMan3G, Laerdal, Stavanger, Norway), referencing the 2020 Korean Professional Cardiopulmonary Resuscitation (CPR) Guidelines. Each team member rotated through different roles to ensure comprehensive role experience. Based on prior research, teams were composed of 5 to 6 members, with each team leader assigned 10 min to lead, totaling 60 min per team to assess the students’ performance in professional cardiac resuscitation [34]. Debriefing involved an evaluative discussion about the nursing practices executed during the simulations. Utilizing a recorded video for reference, the debriefing process was structured into gathering, analyzing, and summarizing phases, employing the GAS model over a 60-minute session.
The fifth Nub lecture is a phase that ensures the educational objectives have been met and clearly summarizes the core content addressed during the class, before the session concludes [16]. In this study, final feedback was provided on the aspects of the simulation that students found challenging, consolidating the core lesson content to ensure achievement of the educational objectives.
The sixth step, Evaluation, involved assessing academic achievement through session-by-session, individual, and team evaluations. The cooperative learning content was assessed individually using a 5-item evaluation.
The seventh step, Reflection, was performed after the session where individuals or teams reflected internally on their learning outcomes, documented in a reflection journal.

Control group’s traditional simulation training program

The control group’s traditional simulation training program spanned two weeks, encompassing two sessions with a total duration of 480 min. Based on prior research, the program was structured according to the traditional lecture sequence: introduction, development, and summary [35]. Interventions in professional cardiopulmonary resuscitation traditional lectures, autonomous practice, and high-fidelity simulation training were informed by prior research, which recommended a week of pre-study prior to simulation training [36]. The first week included an orientation, traditional theoretical lectures, autonomous practice, followed by a question and answer session and summary, totaling 240 min. The second week’s training was conducted identically to the experimental group’s high-fidelity simulation training (240 min). Finally, a post-intervention survey was conducted. For ethical considerations, post-intervention measures (web-based simulation training identical to that of the experimental group) were implemented from December 19 to December 30, 2022.

Post-test

The post-test involved assessing both the experimental and control groups on advanced cardiac life support knowledge, confidence, clinical competence, and learning satisfaction, taking approximately 20–30 min.

Ethical considerations

This study was approved by the Institutional Review Board of K University (approval number 40525-202204-HR-018-13) following a review. After obtaining approval from the head of the nursing department to which the research subjects belonged, third-year nursing students at the College of Nursing, K University in Daegu, who voluntarily wished to participate, were recruited via notices on the college bulletin boards. Participants were not informed in advance of the group they were assigned to, and an orientation regarding the educational program was provided to each group. At the time of applying for the program and during the orientation session, participants were notified that they must attend all surveys and evaluations, both before and after the education. The researcher obtained written consent from the participants after explaining the purpose, necessity, methods, and duration of the study. To ethically protect the participants, it was specified that the collected data would not be used or disclosed for purposes other than the research, and personal information of the participants would not be used for any other purposes. Participants’ rights were protected by ensuring anonymity and informing them that they could refuse or discontinue participation at any time if they wished. During data collection for the program, questionnaires with participant information identification codes were used to protect personal information. It was explained that the collected survey data would be stored for three years and then destroyed using a shredder.

Data analysis

Data analysis was performed using SPSS 27.0 (IBM Corp., Armonk, NY, USA). General characteristics such as age, gender, preferred educational methods, and previous semester grades were analyzed using frequency, percentage, mean, and standard deviation. Normality was tested with the Shapiro-Wilk test. Homogeneity testing for variables was conducted using Fisher’s exact test and Independent t-test, and hypothesis testing was carried out using Repeated Measures ANOVA, Independent t-test, and Mann-Whitney U test.

Results

Homogeneity testing for general characteristics and dependent variables

The homogeneity of general characteristics of nursing students showed no significant differences in age, gender, preferred educational methods, and grades just before the education (Table 1). Pre-test homogeneity for the dependent variables between the experimental and control groups showed no significant differences in advanced cardiac life support knowledge, confidence, and clinical competence (Table 2).
Table 1
Verification of homogeneity of general characteristics of experimental and control groups (N = 34)
Variable
Category
Exp. (n = 17)
Con. (n = 17)
t or Fisher’s
p
N (%) N (%)
exact test
or Mean ± SD or Mean ± SD
 
Age(year)
21.82 ± 1.13
21.41 ± 0.71
-1.27*
0.213
Gender
Female
13(76.5)
15(88.2)
0.81
0.656
Male
4(23.5)
2(11.8)
Preferred Method of Education
Lecture
5(29.4)
7(41.2)
2.56
0.503
Discussion
1(5.9)
2(11.8)
Q&A
0(0)
1(5.9)
Practical Education
11(64.7)
7(41.2)
Last
2.5∼3.0
4(23.5)
2(11.8)
4.61
0.189
Semester
3.0∼3.5
7(41.2)
3(17.6)
Ratings
3.5∼4.0
5(29.4)
11(64.7)
 
4.0∼4.5
1(5.9)
1(5.9)
*Independent t-test
Table 2
Pre-homogeneity verification for dependent variables in experimental and control groups (N = 34)
Variable
Exp. (n = 17)
Con.(n = 17)
t
p
Mean ± SD
Mean ± SD
Knowledge
11.82 ± 4.47
11.35 ± 1.12
-1.05
0.301
Self- Confidence
56.94 ± 6.56
55.41 ± 11.05
-0.49
0.627
Clinical Performance
69.18 ± 2.88
68.94 ± 5.24
-0.16
0.872

Differences in dependent variables between groups

The results indicated significant effects in advanced cardiac life support knowledge by time, group, and the interaction between time and group. Confidence in performance showed significant effects by time, group, and interaction. Performance also showed significant differences, and clinical competence was significant by time, group, and interaction. However, no significant effect was found for learning satisfaction (Table 3).
Table 3
Verifying differences between dependent variables in experimental and control groups (N = 34)
Variable
Group
Pretest
Posttest
categories
F or t*
or z
p
Mean ± SD Mean ± SD
Knowledge
Exp.(n = 17)
11.82 ± 1.47
17.18 ± 1.24
time
158.67
< 0.001
Con.(n = 17)
11.35 ± 1.11
15.20 ± 1.67
group
16.24
< 0.001
time×group
4.4
0.044
Self- Confidence
Exp.(n = 17)
56.94 ± 6.56
91.00 ± 7.85
time
288.42
< 0.001
 
Con.(n = 17)
55.41 ± 11.05
81.88 ± 5.15
group
6.62
0.015
 
time×group
4.53
0.041
Clinical Performance
Exp. (n = 17)
69.18 ± 2.88
91.06 ± 6.14
time
199.88
< 0.001
Con.(n = 17)
68.94 ± 6.17
85.24 ± 4.91
group
8.76
0.006
time×group
4.28
0.047
ACLS Performance
Exp. (n = 17)
 
41.59 ± 2.45
 
-4.89*
< 0.001
Con. (n = 17)
 
35.47 ± 4.54
 
learning Satisfaction
Exp.(n = 17)
 
95.65 ± 6.60
 
129.50
0.584
Con. (n = 17)
 
96.59 ± 5.62
 
*t-test, Mann-whitney U test

Discussion

This study attempted to identify the effects on knowledge, confidence, professional cardiopulmonary resuscitation performance, clinical performance, and learning satisfaction by applying a blended simulation education program for professional cardiopulmonary resuscitation using the PARTNER model for nursing college students. As a result, the intervention-applied experimental group showed significant improvements in knowledge, confidence, advanced cardiac life support performance, and clinical skills compared to the comparison group.
After applying the intervention program, knowledge scores increased by 29% in the experimental group and 20% in the control group, indicating that the educational method used in the experimental group was more effective in enhancing knowledge compared to traditional learning methods. In previous studies, professional cardiopulmonary resuscitation education using flipped learning was effective for nursing students [37]. According to the study by Nugraheni et al., in flipped learning, combining learning methods that involve applying knowledge to real clinical situations to solve problems is reported to be more effective in enhancing knowledge than simply providing materials or video lectures [38]. Therefore, this study suggests that providing web-based simulation training, rather than simple video learning, during the preliminary stage as pre-learning, was effective in enhancing knowledge. Therefore, video lectures and web-based simulation education should be provided together when designing professional cardiopulmonary resuscitation education programs in the future, so that learners can induce critical thinking and cultivate knowledge.
After implementing this intervention program, the confidence score increased by 34% in the experimental group and 26% in the control group. In a study that conducted core nursing education using the PARTNER model, discussions on various clinical situations and repetitive learning opportunities were provided to help increase core nursing-related confidence [14]. In this program, the PARTNER design provided opportunities for repetitive learning in various case-oriented clinical situations. In particular, it is believed to increase confidence in professional cardiac resuscitation by realistically providing various clinical cases through web-based and high-fidelity simulations. Therefore, to improve confidence when planning professional cardiopulmonary resuscitation education program, it is necessary providing opportunities for repetitive learning in the process of pre-learning linkage, cooperative learning, and debriefing in the PARTNER model.
The performance of professional cardiac resuscitation was 13 points higher when the experimental group trained in this intervention program converted to 100 points compared to the control group. In studies that applied flipped learning to professional cardiopulmonary resuscitation simulation education, professional cardiopulmonary resuscitation performance was lower than that of the control group when only various skill-related videos were provided [39]. This is believed to be the result of providing various opportunities to experience virtual clinical situations using blended learning methods that apply various learning methods to pre-learning and main learning, unlike Xin. et al.’s [39], which provided both technical videos and face-to-face simulations. In addition, by experiencing clinical situations through prior learning linkages, professional cardiopulmonary resuscitation performance would increase by participating in face-to-face simulation practice with confidence. However, in studies related to simulation, while self-confidence in performance showed improvement, performance ability did not show significant enhancement [40]. These results are believed to be due to the fact that previous studies primarily conducted simple performance training without incorporating elements such as teamwork and pre-learning activities. As previous studies indicated, evaluation and feedback can be effectively derived when instructors and learners interact in both directions [41]. Therefore, to increase professional cardiopulmonary resuscitation performance, it is necessary to apply a case-based pre-learning simulation and this class simulation by applying a PARTNER model when constructing education and to apply a blended learning method considering cooperative learning that communicates in both directions in this class.
In this study, clinical performance improved to 16.3% in the control group, compared to 22% in the experimental group, which showed a higher rate of increase than in the control group. In a study by Gerasimiak [42], the results were similar to those of learner-centered classes, which were more effective in developing practical application skills using knowledge, compared to lecture-style classes, and improved clinical practice skills by providing opportunities for repeated practice. This program is designed to provide web-based simulation at the pre-stage so that learners can analyze clinical situations and solve nursing problems on their own. In addition, the pre-learning content was strengthened in the pre-learning linkage stage, and sufficient time and self-study opportunities were provided for discussions with team members based on cases. This method of learning has a positive effect on clinical performance by systematically exploring the subjects themselves and inferring complex clinical situations based on logical consistency [43]. In medicine and nursing, where practical training is important, the effectiveness of blended education can be enhanced when repeated learning is combined with prior and face-to-face learning [44]. Therefore, the blended learning method, which provides web-based simulation in the pre-learning stage and applies high-fidelity simulation after pre-linked learning, has proven effective in improving clinical performance by analyzing clinical situations and developing nursing problem-solving skills. Therefore, it is considered that it is necessary to use web-based and high-fidelity simulation blended learning to improve clinical performance in the future professional cardiac resuscitation training plan.
After the intervention of this program, the learning satisfaction score was higher in both groups; however, the difference was not statistically significant. This can be seen because of the small group learning activities in both groups in this study as well, compared with the results of a previous study, which showed that learning satisfaction is higher in small education than in medium and large education [45]. In addition, the study participants were nursing students who voluntarily participated in a complex specialized cardiac resuscitation program, and their learning attitude was positive, which may have affected learning satisfaction [46]. Therefore, as a strategy to increase learning satisfaction, it is necessary to plan small-group activities in educational design and to improve learners’ assertiveness.
In summary, this study applied the PARTNER model to the design of specialized cardiac resuscitation education for nursing students and developed an educational program that blended non-face-to-face web-based simulation pre-learning, face-to-face linked learning, and high-fidelity simulation. Through this, pre-learned knowledge was connected to learning, and an environment with high interaction between instructors and students was created through clinical situation-based cooperative learning. This learning environment improves learners’ engagement and self-directed participation in class, which, in turn, improves their self-confidence, clinical performance, and learning satisfaction [47]. This plays an important role in supplementing the limitations of traditional simulation practical training, which is a one-time and one-way training [48]. Based on these results, it is believed that blended simulation education using the PARTNER model when implementing professional and complex clinical practice education in nursing education will contribute to the development of practical nursing skills by improving nursing students’ confidence in clinical nursing and clinical performance.
The limitations of this study are as follows. First, this study was conducted with nursing students from specific regions, which limits the generalizability of the findings. Second, there were limitations in objectively evaluating the study results due to the insufficient sample size and the challenges in verifying effects through random assignment. Third, this study has limitations in verifying the effects based on the duration and frequency of the intervention, as the education was provided over a short period.

Conclusions

The results of this study demonstrate that nursing students who participated in the blended simulation education program using the PARTNER model efficiently acquired complex ACLS knowledge in scenarios simulating cardiac arrest, thereby enhancing their confidence and immediate and effective performance in ACLS, leading to improved clinical competence. Therefore, this program provides guidelines for applying blended simulation using the PARTNER model in advanced cardiac life support nursing education and can ultimately contribute to training nurses equipped with advanced cardiac life support competencies.

Acknowledgements

The Authors would like to express our gratitude to the Keimyung University College of Nursing, and the study participants for their valuable information.

Declarations

The study was conducted in accordance with the Declaration of Helsinki, and approved by the In-situational Review Board (or Ethics Committee) of KEIMYUNG UNIVERSITY (No. 40525-202204-HR-018-13 and 2022.10.04). for studies involving humans. It is noteworthy that after introducing themselves to students, the researchers explained the study objectives and ensured voluntary participation, the right to withdraw from the study. Informed consent was obtained. All methods were carried out in accordance with relevant guidelines and regulations in the declaration.
Not applicable.

Competing interests

The authors declare no competing interests.
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Metadaten
Titel
Effectiveness of a blended (distance and in-person) simulation education program on advanced cardiac life support for nursing students using the PARTNER model
verfasst von
Miyoung Kang
Eunju Lee
Publikationsdatum
01.12.2025
Verlag
BioMed Central
Erschienen in
BMC Nursing / Ausgabe 1/2025
Elektronische ISSN: 1472-6955
DOI
https://doi.org/10.1186/s12912-025-02684-y