Introduction
Patient safety is essential for patient safety, and patient-centered care encompasses effective drug management to optimize safe and appropriate drug therapy. This management involves critical steps such as verifying medication details, administering drugs as prescribed, accurately calculating dosages, monitoring for effects and adverse reactions, documenting and communicating medication information, and properly storing and handling medications [
1]. Global research indicates that medical errors account for 10 to 18% of healthcare errors, a concern that also extends to the Iranian healthcare system [
2]. Systematic reviews and meta-analyses reveal that the prevalence of medical errors in Iran ranges from 0.06 to 42% [
3]. Furthermore, a 2019 review study highlighted that the prevalence of medical errors in Middle Eastern countries, including Iran, ranges from 11 to 90% [
2].
The World Health Organization (WHO) has identified three critical areas alongside drug safety: safety in high-risk situations, polypharmacy, and care transfer [
4]. National health safety and quality standards implement quality assurance tests to ensure healthcare providers adhere to safety and quality care standards [
5]. The fourth of the eight measures outlined addresses drug safety [
6]. In 2017, the WHO launched its third Global Patient Safety Challenge, “Medication Without Harm,” aiming to reduce preventable medication-related harm by 50% by 2022 [
4]. Despite these efforts, medication errors continue to affect healthcare practices and have significant implications for patient care [
7]. Financially, the estimated annual cost of preventable medical errors in the United States is $20 billion [
8]. According to a WHO report, medication errors cost nearly $42 billion annually, representing 1% of global health expenditures [
4]. These errors have profound medical and financial repercussions, leading to decreased patient trust and satisfaction in healthcare and placing considerable pressure on nurses responsible for such mistakes [
9]. Therefore, nursing education programs must integrate these statistics and insights into their curricula, ensuring that future nurses have the knowledge and skills to minimize medication errors and enhance patient safety.
Ensuring patient safety depends on accurately administering medications, including calculating the correct dosage, prescribing the drug, and monitoring its effects, interactions, and side effects. Current knowledge and skills in medication management are essential [
10,
11]. Nurses are crucial in ensuring medication safety as a critical part of the healthcare team [
12]. They directly manage medications for patients and turn them into the last line of defense in detecting potential medication errors [
12]. Therefore, nurses should acquire clinical reasoning, critical thinking, and professional and clinical competence skills to identify the mistakes that may occur while prescribing, dispensing, and administering medications [
10]. Nursing students must enhance their medication management skills, which are crucial for patient care. This process includes thorough pre-administration assessments to understand patients’ histories, setting care goals, and skillfully prescribing medications while considering potential interactions. Monitoring side effects and promptly addressing adverse reactions are also crucial. Educating patients on proper medication use ensures they understand dosage and timing. By improving these skills, nursing students can enhance medication safety and patient outcomes [
13].
Nursing students should acquire competencies in basic skills related to medication management during their early education [
14]. A nursing student’s self-perception and skills in medication management significantly contribute to ensuring patient safety and minimizing medication errors [
10]. By fostering self-awareness, students can better identify their strengths and weaknesses, which is essential for developing critical thinking abilities [
7]. A firm grasp of drug calculations and administration is vital to making informed decisions in clinical settings. By improving these skills during training, students can increase their confidence and practice safer medication management, ultimately enhancing patient outcomes [
10].
Medication errors are notably prevalent among nursing students, primarily due to their limited clinical experience [
15]. Research indicates that nurses and nursing students report relatively high rates of medication errors, highlighting the importance of self-perception in their training [
16]. For example, a survey by Matin et al. revealed that nearly 53% of nurses in Iran admitted to making medication errors, underscoring the urgent need for improved education on medication safety [
17]. Similarly, a study by Dehvan et al. (2021) found that nursing students in Iran reported a medication error rate of around 40% [
18]. These statistics reflect the challenges nursing professionals face and emphasize the critical need for nursing education programs to enhance students’ self-perception of their medication management skills, ultimately fostering a safety culture in healthcare settings.
Many nursing students find it challenging to safely manage medications, which negatively impacts their self-perception, due to factors such as low student-to-faculty ratios, limited access to healthcare facilities, and the complexities of electronic health record (EHR) systems, which may not be present in all institutions [
15]. Furthermore, nursing students often need help with medication calculations due to problems in understanding mathematical principles [
10,
19]. Clinical stress-inducing environments, lack of communication skills, and distractions can lead to an increased risk of medication errors, significantly impacting nursing students’ ability to provide safe, high-quality patient care and manage medication [
15].
Medication errors continue to be a concern among nursing students, highlighting deficiencies in their educational preparation despite the training they receive [
9]. It is essential to equip students with the skills to identify and manage potential medication side effects. This knowledge is vital for ensuring safe patient care and fostering positive health outcomes, enabling future healthcare professionals to respond effectively in clinical environments [
13]. Nursing students must develop a comprehensive understanding of pharmacology, encompassing the mechanisms, side effects, and proper administration of medications. This education should be woven throughout their training, combining theoretical knowledge with practical clinical experience and case studies. By doing so, we can prepare nursing students to manage complex patient care with confidence and safety [
9,
13].
Numerous studies have rigorously examined safe medication administration to patients, focusing on identifying the causes and types of errors. These investigations highlight significant gaps in nursing students’ proficiency regarding drug safety, as perceived by both managers and patients [
9,
13]. Acknowledging the crucial role of nursing education in promoting patient safety, our collaborative research—conducted with input from nursing educators, healthcare administrators, and researchers—aims to evaluate nursing students’ understanding and knowledge of safe medication management. This study, conducted at Ardabil University of Medical Sciences, seeks to bridge this gap by assessing nursing students’ self-perceived competence in securely handling medications. By connecting evidence of medication errors to the necessity for improved education, we aspire to provide insights that can enhance nursing curricula and ultimately improve patient safety outcomes.
Research question
What is the level of self-perceived competence among nursing students in safe medication management?
How do socio-demographic factors influence their perceptions?
Materials and methods
Design
An analytical cross-sectional study was conducted on nursing students at Ardabil University of Medical Sciences, northwest Iran, from June to August 2023.
Setting and sample
This study focused on nursing students from three nursing schools—Ardabil, Meshgin, and Germi—affiliated with Ardabil University of Medical Sciences in Iran. These three centers were selected based on the Ardabil University of Medical Sciences having three nursing schools with the names mentioned. To participate in the study, candidates must meet specific criteria: they must have completed at least one clinical internship (excluding practical and laboratory units), possess theoretical knowledge of drug management, have practical experience in a healthcare setting, and provide voluntary consent to participate. First-year nursing students were excluded from the study as they had not yet completed the hospital internship and lacked familiarity with self-perceptions related to safe medication management. Additionally, students were excluded if they did not complete the questionnaire or indicated they did not wish to participate.
After obtaining the necessary permissions from the Research Deputy, responsible for overseeing all research activities at Ardabil University of Medical Sciences, a list of eligible students was compiled from the relevant centers. In total, 350 students were identified as meeting the criteria. Using Epi Info StatCalc version 7 (with a confidence interval of 95%, a margin of error of 0.05, and a total population of 523), a sample size of 221 was calculated. Considering an anticipated non-response rate of 20%, the sample size for the study was increased to 265 participants. This adjustment ensures that the final data remains statistically valid and accurately reflects the target population.
The number of participants from each nursing institution was allocated based on the proportion of students enrolled across different academic years. Specifically, Ardabil Nursing and Midwifery School, with its larger student population, contributed 215 students to the sample. Germi Nursing School, which has a smaller academic cohort, provided 30 students, while Meshgin Nursing School contributed 25 students to the overall sample. This proportional distribution of participants is essential for achieving a representative sample from each institution involved in the study. Data collection primarily took place after classes or during students’ free time to minimize disruptions to their academic schedules. Participants were randomly selected from each academic year, resulting in a final sample size 253. Throughout the data collection process, potential challenges faced by participants, such as time constraints or discomfort in answering questions, were closely monitored. Additionally, significant efforts were made to mitigate researcher bias by ensuring neutrality in data collection, thereby preserving the integrity of the study and instilling confidence in its objectivity.
Instruments
We collected data from a demographic information form and the Nursing Students’ Self-Perceptions about Safe Medication Management (NURSPeM) questionnaire [
10]. NURSPeM is designed to assess nursing students’ self-perceptions about safe medication management. It is a self-report instrument comprising two questionnaires: self-perceptions about safe medication management and the frequency and practice of drug dose calculation questionnaire. Participants completed the questionnaires on their own.
The demographic information form included important variables such as age, gender, academic year, previous clinical work experience as a student, duration of clinical work, and whether the participant had completed a training course on drug calculations. Collecting this information is essential for understanding the background of participants and its potential impact on their competencies in medication management [
10].
The self-perceptions about safe medication management questionnaire
The NURSPeM (Nursing Students’ Self-Perceptions about Medication Management) scale is a comprehensive tool developed to evaluate nursing students’ self-perceptions regarding safe medication management practices. Designed by Fuster-Linares et al. in 2022, it consists of 24 items organized into seven dimensions [
10]:
1.
Safety in Drug Prescription.
2.
Familiarity with Pharmacological Concepts.
3.
Relevance for Professional Practice.
4.
Factors Associated with Risk of Error.
5.
Importance of Administering Medication as Prescribed.
6.
Verifications Before Drug Administration.
7.
Thinking Process About Medication Management.
Each item on the questionnaire is scored using a 5-point Likert scale, where responses range from 0 (never) to 4 (always). Higher scores indicate a greater self-perceived awareness of drug safety management among students. Although there is no established cut-off point for these scores, increases suggest improved self-perception and understanding of medication safety practices. At the same time, decreases may indicate areas needing further attention or training.
The original tool’s Cronbach’s alpha coefficient was reported as 0.89 in the study by Fuster-Linares et al. [
10]. Our study found a Cronbach’s alpha 0.92, indicating excellent internal consistency. The intraclass correlation coefficient (ICC) was also calculated at 0.89, demonstrating good reliability for our sample. Notably, the NURSPeM scale does not contain reverse-scored items.
The frequency and practice of drug dose calculation questionnaire
This questionnaire, also designed by Fuster-Linares et al. in 2022, assesses the frequency of medication calculation practices and consists of 13 items divided into two subscales [
10]:
1.
Frequency of drug dose calculation (11 items)
2.
Learning drug dose calculation (2 items)
Responses are scored on a 5-point Likert scale, ranging from 0 points (never) to 4 points (daily). Higher scores reflect a greater frequency of medication dose calculation and repeated learning; however, no established cut-off point exists for these scores.
The original tool’s Cronbach’s alpha coefficient was reported as 0.89 in the study by Fuster-Linares et al. [
10]. Our study found a Cronbach’s alpha of 0.909, indicating excellent internal consistency. The intraclass correlation coefficient (ICC) was 0.88, demonstrating good reliability for our sample. It is important to note that we did not conduct a test-retest reliability assessment for this study. Further investigation may be necessary to evaluate the stability of the scores over time.
Content validity of the NURSPeM questionnaire
Before using these questionnaires for the first time in Iran, we obtained permission from the original questionnaire designer. Two language experts translated the questions from English to Persian and then re-translated them to English by two independent experts. After aligning the questions with the original questionnaire, we asked ten faculty members of the Nursing and Midwifery School of Ardabil University of Medical Sciences to examine their content validity. We used the content validity ratio (CVR) and content validity index (CVI) to assess content validity. The expert faculty members evaluated each question based on three response options: “essential,” “useful but not essential,” and “not necessary.” The CVI was calculated by averaging the responses for each question, and a CVI value exceeding 0.78 was considered acceptable [
20]. The CVR and CVI were determined to be 0.82 and 0.93, respectively, demonstrating a high level of validity for this scale among Iranian nursing students and providing strong assurance about the content validity of the questionnaire.
Data analysis
The data were analyzed using SPSS version 22.0 (SPSS Inc., Chicago, IL, USA). The self-efficacy level of nursing students in safe drug management and its dimensions, drug dose calculation repetition and learning dimensions, and demographic characteristics of students were analyzed using descriptive statistics (frequency, percentage, mean, standard deviation (SD), and range). The relationship between nursing students’ self-efficacy in safe drug management and drug dose calculation repetition and learning with demographic characteristics was examined using independent-sample t-test, one-way ANOVA, and Pearson’s correlation coefficient. The Scheffé posthoc test was conducted to determine the specific group differences for the academic year and GPA variables, as the overall ANOVA results were significant. The Scheffé test is a conservative approach that controls the familywise error rate and allows for pairwise comparisons between all possible combinations of groups. This additional analysis provides more detailed information about which specific groups differed significantly from each other in terms of self-perceptions about safe medication management and frequency and learning of drug-dose calculation. Before conducting statistical tests, the normality of the data distribution was checked using the Kolmogorov-Smirnov one-sample test. Using multiple linear regression, participants analyzed predictive factors for nursing students’ self-efficacy in safe drug management and drug dose calculation repetition and learning.
Results
A total of 253 nursing students participated in this study. This group’s mean (standard deviation) age was 21.76 ± 2.08. Most students (51.8%) were male and single (58.5%). Regarding the academic year, 32.4% of students were in their second year, 32.2% in their third year, and 30.4% in their fourth year. Additionally, 81% of these students were studying at Ardabil Nursing School. 15.8% had work experience in health services, and 19.4% had completed a training course in drug calculation. The results of demographic characteristics are presented in Table
1.
Table 1
Sociodemographic characteristics of the participants (n = 253)
Age (year) | | 21.76 ± 2.08 | |
| | (%) | (n) |
Gender | Male | 51.8 | 131 |
| Female | 48.2 | 122 |
Marital status | Single | 58.5 | 148 |
| Married | 41.5 | 105 |
Academic year | Second | 32.4 | 82 |
| Third | 32.2 | 94 |
| Fourth | 30.4 | 77 |
Grade point average (GPA) | 17.5–20 | 20.9 | 53 |
15-17.5 | 42.7 | 63.6 |
| 12.5–15 | 36.4 | 92 |
Nursing school | Ardabil | 81.0 | 205 |
| Meshgin | 10.3 | 26 |
| Germi | 8.7 | 22 |
Experience working in health service | Yes | 15.8 | 40 |
No | 84.2 | 213 |
Performed course in drug calculation | Yes | 19.4 | 49 |
No | 80.6 | 204 |
The mean score for participants’ self-perceptions regarding safe medication management was 57.65 ± 13.53 (range = 24–96). The highest and lowest average scores were related to administering medication as prescribed (11.88 ± 2.61) and verifications before drug administration (6.48 ± 2.46), respectively. Additionally, the overall average score for frequency and practice of drug dose calculation was 31.62 ± 11.65 (range = 13–52) for all participants, with the highest average score being related to the frequency of drug-dose calculation (26.73 ± 8.09) (Table
2).
Table 2
Summary of the results obtained for the dimensions of the NURSPeM (n = 253)
Self-perceptions about safe medication management | 31–96 | 57.65 | 13.53 | 0.909 | 0.898 |
Safety in drug prescription | 0–16 | 9.06 | 3.36 | 0.798 | |
Familiarity with pharmacological concepts | 2–16 | 8.65 | 3.51 | 0.798 | |
Relevance for professional practice | 0–4 | 2.24 | 0.72 | 0.717 | |
Factors associated with risk of error | 3–12 | 8.20 | 2.08 | 0.761 | |
Importance of administering medication as prescribed | 4–16 | 11.88 | 2.61 | 0.768 | |
Verifications prior to drug administration | 1–12 | 6.48 | 2.46 | 0.734 | |
Thinking process in relation to medication management | 4–20 | 11.13 | 3.56 | 0.766 | |
Frequency and learning of drug-dose calculation | 12–52 | 31.62 | 9.02 | 0.880 | 0.879 |
Frequency of drug dose calculation | 8–44 | 26.73 | 8.09 | 0.836 | |
Learning drug dose calculation | 2–8 | 4.89 | 1.55 | 0.753 | |
Table
3 presents the differences in self-perceptions regarding safe medication management based on participants’ characteristics. Significant statistical correlations were observed between self-perceptions about safe medication management and various sociodemographic variables, including academic year (F = 31.267,
p < 0.001, using a one-way ANOVA to compare the means of three or more groups), grade point average (GPA, calculated by dividing the total number of grade points earned by the total number of credits taken) (F = 38.098–2.049,
p < 0.001, with linear regression used to predict GPA), and experience working in health services (t = 10.367,
p < 0.001, employing a t-test to compare means of two groups). These findings suggest that these factors significantly influence students’ perceptions of safe medication management. Specifically, students in their fourth year with a GPA of 17.5–20 and experience working in health centers achieved higher scores in self-perceptions about safe medication management. Additionally, there was a significant correlation between the frequency of learning drug-dose calculations and certain sociodemographic variables, including academic year (F = 6.671,
p = 0.002), GPA (F = 14.065,
p < 0.001), and experience working in health services (t = 5.394,
p < 0.001). Students with a GPA of 17.5–20 and experience working in health centers, particularly those in their first and fourth years, scored higher in both the frequency of learning drug-dose calculations and their overall understanding of safe medication management.
Table 3
Association between the participants’ characteristics and self-perceptions about safe medication management (n = 253)
Age | 0.121 | 0.098 | | | | 0.054 | 0.392 | |
Gender | Male | 67.70 ± 15.13 | -1.140 | 0.256 | | | 41.74 ± 11.49 | -0.626 | 0.532 | | |
Female | 65.45 ± 16.31 | | 40.81 ± 11.85 | |
Marital status | Single | 65.27 ± 14.55 | -1.619 | 0.117 | | | 41.20 ± 11.04 | -0.138 | 0.891 | | |
Married | 68.51 ± 17.13 | | 41.41 ± 12.52 | |
Academic year | (1) Second | 63.51 ± 11.64 | 31.267 | < 0.001* | 3 > 1, 2 | | 43.01 ± 9.99 | 6.671 | 0.002* | 1, 3 > 2 | |
(2) Third | 60.75 ± 14.29 | | 37.90 ± 10.76 | |
(3) Fourth | 77.09 ± 16.15 | | 43.61 ± 13.40 | |
GPA | (1)17.5–20 | 80.86 ± 17.05 | 38.098 | < 0.001* | 1 > 2, 3 | | 48.39 ± 10.77 | 14.065 | < 0.001* | 1 > 2, 3 | |
(2)15-17.5 | 64.85 ± 12.29 | | 38.81 ± 11.15 | |
(3)12.5–15 | 60.48 ± 13.44 | | 40.11 ± 11.21 | |
Nursing school | Ardabil | 67.08 ± 15.95 | 1.168 | 0.313 | | | 41.31 ± 12.02 | 0.023 | 0.0977 | | |
Meshgin | 67.11 ± 16.61 | | 40.88 ± 10.81 | |
Germi | 61.72 ± 11.71 | | 41.59 ± 9.31 | |
Experience working in health service | Yes | 86.45 ± 14.77 | 10.367 | < 0.001* | | | 50.95 ± 12.64 | 5.394 | < 0.001* | | |
No | 62.89 ± 12.86 | | 39.48 ± 10.54 | |
Performed course in drug calculation | Yes | 66.20 ± 14.92 | -0.206 | 0.837 | | | 42.32 ± 13.84 | 0.068 | 0.492 | | |
No | 66.72 ± 15.94 | | 41.04 ± 11.09 | |
This study used multiple linear regression analysis to examine the impact of variables on nursing students’ self-perceptions about safe medication management (Table
4). All statistically significant variables identified in the univariate analysis were selected as independent variables to determine predictors of self-perceptions about safe medication management and frequency and learning of drug-dose calculation. The results showed that age, academic year, GPA, and experience working in health service were predictors of self-perceptions about safe medication management. Overall, the selected predictors for self-perceptions about safe medication management and frequency and learning of drug-dose calculation predicted 51.6% (F = 23.391,
p < 0.001) and 25.2% (F = 7.363,
p < 0.001) of the total variance, respectively.
Table 4
Linear regression analysis coefficients to examine predictors of the self-perceptions about safe medication management (n = 253)
(Constant) | 86.187 | | 10.304 | < 0.001 | 34.441 | | 4.964 | < 0.001 | |
Age | -0.384 | -0.59 | -1.048 | 0.296 | 0.618 | 0.143 | 2.033 | 0.043 | |
Gender (Female = 0a) | 1.820 | 0.067 | 1.489 | 0.138 | 0.686 | 0.038 | 0.677 | 0.499 | |
Marital status (Single = 0a) | 1.583 | 0.058 | 1.173 | 0.242 | -1.019 | -0.056 | -0.910 | 0.364 | |
Academic year (Second = 0a) | | | | | | | | | |
Third | -2.589 | -0.093 | 1.640 | 0.102 | -4.758 | -0.255 | -3.634 | < 0.001 | |
Fourth | 4.372 | 0.149 | 2.260 | 0.025 | -5.055 | -0.258 | -3.151 | 0.002 | |
Grade point average (17.5–20 = 0a) | | | | | | | | | |
15-17.5 | -9.085 | -0.333 | -5.346 | < 0.001 | -5.929 | -0.326 | -4.206 | < 0.001 | |
12.5–15 | -14.516 | -0.517 | -8.430 | < 0.001 | -5.799 | -0.310 | -4.060 | 0.000 | |
Nursing school (Ardabil = 0a) | | | | | | | | | |
Meshgin | -0.446 | -0.010 | -0.216 | 0.829 | 0.367 | 0.012 | 0.214 | 0.830 | |
Germi | -3.969 | -0.083 | -1.785 | 0.075 | 0.319 | 0.010 | 0.173 | 0.863 | |
Experience working in health service (Yes = 0a) | -15.164 | -0.410 | -7.665 | < 0.001 | -8.812 | -0.357 | -5.370 | < 0.001 | |
Performed course in drug calculation (Yes = 0a) | 0.224 | 0.007 | 0.137 | 0.891 | -1.133 | -0.050 | -0.834 | 0.405 | |
Model characteristics | R = 0.719, R2 = 0.516, Adjusted R2 = 0.494, F = 23.391 | R = 0.502, R2 = 0.252, Adjusted R2 = 0.217, F = 7.363 |
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