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Erschienen in:

Open Access 01.12.2025 | Research

Assessing self-perceptions related to safe medication management among nursing students: an analytical cross-sectional study in Iran

verfasst von: Reza Nemati-Vakilabad, Maryam Hashemian, Mohammad Reza Mojebi, Alireza Mirzaei

Erschienen in: BMC Nursing | Ausgabe 1/2025

Abstract Background Objective Design Method Results Conclusion

Ensuring patient safety is critical, with safe medication management being a key aspect. However, nursing students often lack the necessary skills for effective medication management. These students need to acquire the required competencies during their undergraduate studies.
This study aimed to investigate the self-perceived status of Iranian nursing students in medication safety management.
An analytical cross-sectional study.
The study involved 221 nursing students who completed surveys assessing their self-perception of drug management and dosage calculation. Demographic data were also collected. The data collection forms included a self-perception questionnaire and a dosage calculation test. Analytical tests such as independent sample t-tests, one-way ANOVA, Pearson’s correlation coefficient, and descriptive statistics were employed for data analysis using SPSS 22.0 software.
Our research found that the average self-perception score of students in medication management was 57.65 ± 13.53 (range = 24–96). Linear regression analysis revealed that higher overall GPAs (F = 38.098, p < 0.001) and work experience in a hospital (t = 10.367, p < 0.001) were associated with improved self-perception skills in medication management. Additionally, individuals with increasing age demonstrated better self-assessment skills in managing safe medications.
This study underscores the importance of nursing education in enhancing students’ competencies in safe medication management. Specific interventions are recommended to improve knowledge and skills, and sociodemographic factors can help identify students needing additional support. Increasing clinical exposure is also suggested to enhance their competencies.
Hinweise

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Introduction

Patient safety is essential for patient safety, and patient-centered care encompasses effective drug management to optimize safe and appropriate drug therapy. This management involves critical steps such as verifying medication details, administering drugs as prescribed, accurately calculating dosages, monitoring for effects and adverse reactions, documenting and communicating medication information, and properly storing and handling medications [1]. Global research indicates that medical errors account for 10 to 18% of healthcare errors, a concern that also extends to the Iranian healthcare system [2]. Systematic reviews and meta-analyses reveal that the prevalence of medical errors in Iran ranges from 0.06 to 42% [3]. Furthermore, a 2019 review study highlighted that the prevalence of medical errors in Middle Eastern countries, including Iran, ranges from 11 to 90% [2].
The World Health Organization (WHO) has identified three critical areas alongside drug safety: safety in high-risk situations, polypharmacy, and care transfer [4]. National health safety and quality standards implement quality assurance tests to ensure healthcare providers adhere to safety and quality care standards [5]. The fourth of the eight measures outlined addresses drug safety [6]. In 2017, the WHO launched its third Global Patient Safety Challenge, “Medication Without Harm,” aiming to reduce preventable medication-related harm by 50% by 2022 [4]. Despite these efforts, medication errors continue to affect healthcare practices and have significant implications for patient care [7]. Financially, the estimated annual cost of preventable medical errors in the United States is $20 billion [8]. According to a WHO report, medication errors cost nearly $42 billion annually, representing 1% of global health expenditures [4]. These errors have profound medical and financial repercussions, leading to decreased patient trust and satisfaction in healthcare and placing considerable pressure on nurses responsible for such mistakes [9]. Therefore, nursing education programs must integrate these statistics and insights into their curricula, ensuring that future nurses have the knowledge and skills to minimize medication errors and enhance patient safety.
Ensuring patient safety depends on accurately administering medications, including calculating the correct dosage, prescribing the drug, and monitoring its effects, interactions, and side effects. Current knowledge and skills in medication management are essential [10, 11]. Nurses are crucial in ensuring medication safety as a critical part of the healthcare team [12]. They directly manage medications for patients and turn them into the last line of defense in detecting potential medication errors [12]. Therefore, nurses should acquire clinical reasoning, critical thinking, and professional and clinical competence skills to identify the mistakes that may occur while prescribing, dispensing, and administering medications [10]. Nursing students must enhance their medication management skills, which are crucial for patient care. This process includes thorough pre-administration assessments to understand patients’ histories, setting care goals, and skillfully prescribing medications while considering potential interactions. Monitoring side effects and promptly addressing adverse reactions are also crucial. Educating patients on proper medication use ensures they understand dosage and timing. By improving these skills, nursing students can enhance medication safety and patient outcomes [13].
Nursing students should acquire competencies in basic skills related to medication management during their early education [14]. A nursing student’s self-perception and skills in medication management significantly contribute to ensuring patient safety and minimizing medication errors [10]. By fostering self-awareness, students can better identify their strengths and weaknesses, which is essential for developing critical thinking abilities [7]. A firm grasp of drug calculations and administration is vital to making informed decisions in clinical settings. By improving these skills during training, students can increase their confidence and practice safer medication management, ultimately enhancing patient outcomes [10].
Medication errors are notably prevalent among nursing students, primarily due to their limited clinical experience [15]. Research indicates that nurses and nursing students report relatively high rates of medication errors, highlighting the importance of self-perception in their training [16]. For example, a survey by Matin et al. revealed that nearly 53% of nurses in Iran admitted to making medication errors, underscoring the urgent need for improved education on medication safety [17]. Similarly, a study by Dehvan et al. (2021) found that nursing students in Iran reported a medication error rate of around 40% [18]. These statistics reflect the challenges nursing professionals face and emphasize the critical need for nursing education programs to enhance students’ self-perception of their medication management skills, ultimately fostering a safety culture in healthcare settings.
Many nursing students find it challenging to safely manage medications, which negatively impacts their self-perception, due to factors such as low student-to-faculty ratios, limited access to healthcare facilities, and the complexities of electronic health record (EHR) systems, which may not be present in all institutions [15]. Furthermore, nursing students often need help with medication calculations due to problems in understanding mathematical principles [10, 19]. Clinical stress-inducing environments, lack of communication skills, and distractions can lead to an increased risk of medication errors, significantly impacting nursing students’ ability to provide safe, high-quality patient care and manage medication [15].
Medication errors continue to be a concern among nursing students, highlighting deficiencies in their educational preparation despite the training they receive [9]. It is essential to equip students with the skills to identify and manage potential medication side effects. This knowledge is vital for ensuring safe patient care and fostering positive health outcomes, enabling future healthcare professionals to respond effectively in clinical environments [13]. Nursing students must develop a comprehensive understanding of pharmacology, encompassing the mechanisms, side effects, and proper administration of medications. This education should be woven throughout their training, combining theoretical knowledge with practical clinical experience and case studies. By doing so, we can prepare nursing students to manage complex patient care with confidence and safety [9, 13].
Numerous studies have rigorously examined safe medication administration to patients, focusing on identifying the causes and types of errors. These investigations highlight significant gaps in nursing students’ proficiency regarding drug safety, as perceived by both managers and patients [9, 13]. Acknowledging the crucial role of nursing education in promoting patient safety, our collaborative research—conducted with input from nursing educators, healthcare administrators, and researchers—aims to evaluate nursing students’ understanding and knowledge of safe medication management. This study, conducted at Ardabil University of Medical Sciences, seeks to bridge this gap by assessing nursing students’ self-perceived competence in securely handling medications. By connecting evidence of medication errors to the necessity for improved education, we aspire to provide insights that can enhance nursing curricula and ultimately improve patient safety outcomes.

Research question

What is the level of self-perceived competence among nursing students in safe medication management?
How do socio-demographic factors influence their perceptions?

Materials and methods

Design

An analytical cross-sectional study was conducted on nursing students at Ardabil University of Medical Sciences, northwest Iran, from June to August 2023.

Setting and sample

This study focused on nursing students from three nursing schools—Ardabil, Meshgin, and Germi—affiliated with Ardabil University of Medical Sciences in Iran. These three centers were selected based on the Ardabil University of Medical Sciences having three nursing schools with the names mentioned. To participate in the study, candidates must meet specific criteria: they must have completed at least one clinical internship (excluding practical and laboratory units), possess theoretical knowledge of drug management, have practical experience in a healthcare setting, and provide voluntary consent to participate. First-year nursing students were excluded from the study as they had not yet completed the hospital internship and lacked familiarity with self-perceptions related to safe medication management. Additionally, students were excluded if they did not complete the questionnaire or indicated they did not wish to participate.
After obtaining the necessary permissions from the Research Deputy, responsible for overseeing all research activities at Ardabil University of Medical Sciences, a list of eligible students was compiled from the relevant centers. In total, 350 students were identified as meeting the criteria. Using Epi Info StatCalc version 7 (with a confidence interval of 95%, a margin of error of 0.05, and a total population of 523), a sample size of 221 was calculated. Considering an anticipated non-response rate of 20%, the sample size for the study was increased to 265 participants. This adjustment ensures that the final data remains statistically valid and accurately reflects the target population.
The number of participants from each nursing institution was allocated based on the proportion of students enrolled across different academic years. Specifically, Ardabil Nursing and Midwifery School, with its larger student population, contributed 215 students to the sample. Germi Nursing School, which has a smaller academic cohort, provided 30 students, while Meshgin Nursing School contributed 25 students to the overall sample. This proportional distribution of participants is essential for achieving a representative sample from each institution involved in the study. Data collection primarily took place after classes or during students’ free time to minimize disruptions to their academic schedules. Participants were randomly selected from each academic year, resulting in a final sample size 253. Throughout the data collection process, potential challenges faced by participants, such as time constraints or discomfort in answering questions, were closely monitored. Additionally, significant efforts were made to mitigate researcher bias by ensuring neutrality in data collection, thereby preserving the integrity of the study and instilling confidence in its objectivity.

Instruments

We collected data from a demographic information form and the Nursing Students’ Self-Perceptions about Safe Medication Management (NURSPeM) questionnaire [10]. NURSPeM is designed to assess nursing students’ self-perceptions about safe medication management. It is a self-report instrument comprising two questionnaires: self-perceptions about safe medication management and the frequency and practice of drug dose calculation questionnaire. Participants completed the questionnaires on their own.

Demographic information form

The demographic information form included important variables such as age, gender, academic year, previous clinical work experience as a student, duration of clinical work, and whether the participant had completed a training course on drug calculations. Collecting this information is essential for understanding the background of participants and its potential impact on their competencies in medication management [10].

The self-perceptions about safe medication management questionnaire

The NURSPeM (Nursing Students’ Self-Perceptions about Medication Management) scale is a comprehensive tool developed to evaluate nursing students’ self-perceptions regarding safe medication management practices. Designed by Fuster-Linares et al. in 2022, it consists of 24 items organized into seven dimensions [10]:
1.
Safety in Drug Prescription.
 
2.
Familiarity with Pharmacological Concepts.
 
3.
Relevance for Professional Practice.
 
4.
Factors Associated with Risk of Error.
 
5.
Importance of Administering Medication as Prescribed.
 
6.
Verifications Before Drug Administration.
 
7.
Thinking Process About Medication Management.
 
Each item on the questionnaire is scored using a 5-point Likert scale, where responses range from 0 (never) to 4 (always). Higher scores indicate a greater self-perceived awareness of drug safety management among students. Although there is no established cut-off point for these scores, increases suggest improved self-perception and understanding of medication safety practices. At the same time, decreases may indicate areas needing further attention or training.
The original tool’s Cronbach’s alpha coefficient was reported as 0.89 in the study by Fuster-Linares et al. [10]. Our study found a Cronbach’s alpha 0.92, indicating excellent internal consistency. The intraclass correlation coefficient (ICC) was also calculated at 0.89, demonstrating good reliability for our sample. Notably, the NURSPeM scale does not contain reverse-scored items.

The frequency and practice of drug dose calculation questionnaire

This questionnaire, also designed by Fuster-Linares et al. in 2022, assesses the frequency of medication calculation practices and consists of 13 items divided into two subscales [10]:
1.
Frequency of drug dose calculation (11 items)
 
2.
Learning drug dose calculation (2 items)
 
Responses are scored on a 5-point Likert scale, ranging from 0 points (never) to 4 points (daily). Higher scores reflect a greater frequency of medication dose calculation and repeated learning; however, no established cut-off point exists for these scores.
The original tool’s Cronbach’s alpha coefficient was reported as 0.89 in the study by Fuster-Linares et al. [10]. Our study found a Cronbach’s alpha of 0.909, indicating excellent internal consistency. The intraclass correlation coefficient (ICC) was 0.88, demonstrating good reliability for our sample. It is important to note that we did not conduct a test-retest reliability assessment for this study. Further investigation may be necessary to evaluate the stability of the scores over time.

Content validity of the NURSPeM questionnaire

Before using these questionnaires for the first time in Iran, we obtained permission from the original questionnaire designer. Two language experts translated the questions from English to Persian and then re-translated them to English by two independent experts. After aligning the questions with the original questionnaire, we asked ten faculty members of the Nursing and Midwifery School of Ardabil University of Medical Sciences to examine their content validity. We used the content validity ratio (CVR) and content validity index (CVI) to assess content validity. The expert faculty members evaluated each question based on three response options: “essential,” “useful but not essential,” and “not necessary.” The CVI was calculated by averaging the responses for each question, and a CVI value exceeding 0.78 was considered acceptable [20]. The CVR and CVI were determined to be 0.82 and 0.93, respectively, demonstrating a high level of validity for this scale among Iranian nursing students and providing strong assurance about the content validity of the questionnaire.

Data analysis

The data were analyzed using SPSS version 22.0 (SPSS Inc., Chicago, IL, USA). The self-efficacy level of nursing students in safe drug management and its dimensions, drug dose calculation repetition and learning dimensions, and demographic characteristics of students were analyzed using descriptive statistics (frequency, percentage, mean, standard deviation (SD), and range). The relationship between nursing students’ self-efficacy in safe drug management and drug dose calculation repetition and learning with demographic characteristics was examined using independent-sample t-test, one-way ANOVA, and Pearson’s correlation coefficient. The Scheffé posthoc test was conducted to determine the specific group differences for the academic year and GPA variables, as the overall ANOVA results were significant. The Scheffé test is a conservative approach that controls the familywise error rate and allows for pairwise comparisons between all possible combinations of groups. This additional analysis provides more detailed information about which specific groups differed significantly from each other in terms of self-perceptions about safe medication management and frequency and learning of drug-dose calculation. Before conducting statistical tests, the normality of the data distribution was checked using the Kolmogorov-Smirnov one-sample test. Using multiple linear regression, participants analyzed predictive factors for nursing students’ self-efficacy in safe drug management and drug dose calculation repetition and learning.

Results

A total of 253 nursing students participated in this study. This group’s mean (standard deviation) age was 21.76 ± 2.08. Most students (51.8%) were male and single (58.5%). Regarding the academic year, 32.4% of students were in their second year, 32.2% in their third year, and 30.4% in their fourth year. Additionally, 81% of these students were studying at Ardabil Nursing School. 15.8% had work experience in health services, and 19.4% had completed a training course in drug calculation. The results of demographic characteristics are presented in Table 1.
Table 1
Sociodemographic characteristics of the participants (n = 253)
Variables
Categories
Mean ± SD
 
Age (year)
 
21.76 ± 2.08
 
  
(%)
(n)
Gender
Male
51.8
131
 
Female
48.2
122
Marital status
Single
58.5
148
 
Married
41.5
105
Academic year
Second
32.4
82
 
Third
32.2
94
 
Fourth
30.4
77
Grade point average (GPA)
17.5–20
20.9
53
15-17.5
42.7
63.6
 
12.5–15
36.4
92
Nursing school
Ardabil
81.0
205
 
Meshgin
10.3
26
 
Germi
8.7
22
Experience working in health service
Yes
15.8
40
No
84.2
213
Performed course in drug calculation
Yes
19.4
49
No
80.6
204
The mean score for participants’ self-perceptions regarding safe medication management was 57.65 ± 13.53 (range = 24–96). The highest and lowest average scores were related to administering medication as prescribed (11.88 ± 2.61) and verifications before drug administration (6.48 ± 2.46), respectively. Additionally, the overall average score for frequency and practice of drug dose calculation was 31.62 ± 11.65 (range = 13–52) for all participants, with the highest average score being related to the frequency of drug-dose calculation (26.73 ± 8.09) (Table 2).
Table 2
Summary of the results obtained for the dimensions of the NURSPeM (n = 253)
Dimensions
Min-Max
Mean
SD
Reliability
 
Alpha
ICC
Self-perceptions about safe medication management
31–96
57.65
13.53
0.909
0.898
Safety in drug prescription
0–16
9.06
3.36
0.798
 
Familiarity with pharmacological concepts
2–16
8.65
3.51
0.798
 
Relevance for professional practice
0–4
2.24
0.72
0.717
 
Factors associated with risk of error
3–12
8.20
2.08
0.761
 
Importance of administering medication as prescribed
4–16
11.88
2.61
0.768
 
Verifications prior to drug administration
1–12
6.48
2.46
0.734
 
Thinking process in relation to medication management
4–20
11.13
3.56
0.766
 
Frequency and learning of drug-dose calculation
12–52
31.62
9.02
0.880
0.879
Frequency of drug dose calculation
8–44
26.73
8.09
0.836
 
Learning drug dose calculation
2–8
4.89
1.55
0.753
 
Abbreviations: SD, standard deviation; ICC, Intraclass correlation. Note: The minimum and maximum possible scores for each dimension are: Self-perceptions about safe medication management: 0–96, Safety in drug prescription: 0–16, Familiarity with pharmacological concepts: 0–16, Relevance for professional practice: 0–4, Factors associated with risk of error: 0–12, Importance of administering medication as prescribed: 0–16, Verifications prior to drug administration: 0–12, Thinking process in relation to medication management: 0–20, Frequency and learning of drug-dose calculation: 0–52, Frequency of drug dose calculation: 0–44, Learning drug dose calculation: 0–8
Table 3 presents the differences in self-perceptions regarding safe medication management based on participants’ characteristics. Significant statistical correlations were observed between self-perceptions about safe medication management and various sociodemographic variables, including academic year (F = 31.267, p < 0.001, using a one-way ANOVA to compare the means of three or more groups), grade point average (GPA, calculated by dividing the total number of grade points earned by the total number of credits taken) (F = 38.098–2.049, p < 0.001, with linear regression used to predict GPA), and experience working in health services (t = 10.367, p < 0.001, employing a t-test to compare means of two groups). These findings suggest that these factors significantly influence students’ perceptions of safe medication management. Specifically, students in their fourth year with a GPA of 17.5–20 and experience working in health centers achieved higher scores in self-perceptions about safe medication management. Additionally, there was a significant correlation between the frequency of learning drug-dose calculations and certain sociodemographic variables, including academic year (F = 6.671, p = 0.002), GPA (F = 14.065, p < 0.001), and experience working in health services (t = 5.394, p < 0.001). Students with a GPA of 17.5–20 and experience working in health centers, particularly those in their first and fourth years, scored higher in both the frequency of learning drug-dose calculations and their overall understanding of safe medication management.
Table 3
Association between the participants’ characteristics and self-perceptions about safe medication management (n = 253)
Variables
Categories
Self-perceptions about safe medication
 
Frequency and learning of drug-dose
 
M ± SD
r/t/F-value
p
Scheffé
M ± SD
r/t/F-value
p
Scheffé
 
Age
0.121
0.098
   
0.054
0.392
 
Gender
Male
67.70 ± 15.13
-1.140
0.256
  
41.74 ± 11.49
-0.626
0.532
  
Female
65.45 ± 16.31
 
40.81 ± 11.85
 
Marital status
Single
65.27 ± 14.55
-1.619
0.117
  
41.20 ± 11.04
-0.138
0.891
  
Married
68.51 ± 17.13
 
41.41 ± 12.52
 
Academic year
(1) Second
63.51 ± 11.64
31.267
< 0.001*
3 > 1, 2
 
43.01 ± 9.99
6.671
0.002*
1, 3 > 2
 
(2) Third
60.75 ± 14.29
 
37.90 ± 10.76
 
(3) Fourth
77.09 ± 16.15
 
43.61 ± 13.40
 
GPA
(1)17.5–20
80.86 ± 17.05
38.098
< 0.001*
1 > 2, 3
 
48.39 ± 10.77
14.065
< 0.001*
1 > 2, 3
 
(2)15-17.5
64.85 ± 12.29
 
38.81 ± 11.15
 
(3)12.5–15
60.48 ± 13.44
 
40.11 ± 11.21
 
Nursing school
Ardabil
67.08 ± 15.95
1.168
0.313
  
41.31 ± 12.02
0.023
0.0977
  
Meshgin
67.11 ± 16.61
 
40.88 ± 10.81
 
Germi
61.72 ± 11.71
 
41.59 ± 9.31
 
Experience working in health service
Yes
86.45 ± 14.77
10.367
< 0.001*
  
50.95 ± 12.64
5.394
< 0.001*
  
No
62.89 ± 12.86
 
39.48 ± 10.54
 
Performed course in drug calculation
Yes
66.20 ± 14.92
-0.206
0.837
  
42.32 ± 13.84
0.068
0.492
  
No
66.72 ± 15.94
 
41.04 ± 11.09
 
Note. Correlation is significant at the *p < 0.05 level
This study used multiple linear regression analysis to examine the impact of variables on nursing students’ self-perceptions about safe medication management (Table 4). All statistically significant variables identified in the univariate analysis were selected as independent variables to determine predictors of self-perceptions about safe medication management and frequency and learning of drug-dose calculation. The results showed that age, academic year, GPA, and experience working in health service were predictors of self-perceptions about safe medication management. Overall, the selected predictors for self-perceptions about safe medication management and frequency and learning of drug-dose calculation predicted 51.6% (F = 23.391, p < 0.001) and 25.2% (F = 7.363, p < 0.001) of the total variance, respectively.
Table 4
Linear regression analysis coefficients to examine predictors of the self-perceptions about safe medication management (n = 253)
  
Self-perceptions about safe medication management
 
Frequency and learning of drug-dose calculation
 
Predictor
B
Beta b
t
p-value
B
Beta b
t
p-value
 
(Constant)
86.187
 
10.304
< 0.001
34.441
 
4.964
< 0.001
 
Age
-0.384
-0.59
-1.048
0.296
0.618
0.143
2.033
0.043
 
Gender
(Female = 0a)
1.820
0.067
1.489
0.138
0.686
0.038
0.677
0.499
 
Marital status (Single = 0a)
1.583
0.058
1.173
0.242
-1.019
-0.056
-0.910
0.364
 
Academic year
(Second = 0a)
         
Third
-2.589
-0.093
1.640
0.102
-4.758
-0.255
-3.634
< 0.001
 
Fourth
4.372
0.149
2.260
0.025
-5.055
-0.258
-3.151
0.002
 
Grade point average
(17.5–20 = 0a)
         
15-17.5
-9.085
-0.333
-5.346
< 0.001
-5.929
-0.326
-4.206
< 0.001
 
12.5–15
-14.516
-0.517
-8.430
< 0.001
-5.799
-0.310
-4.060
0.000
 
Nursing school
(Ardabil = 0a)
         
Meshgin
-0.446
-0.010
-0.216
0.829
0.367
0.012
0.214
0.830
 
Germi
-3.969
-0.083
-1.785
0.075
0.319
0.010
0.173
0.863
 
Experience working in health service (Yes = 0a)
-15.164
-0.410
-7.665
< 0.001
-8.812
-0.357
-5.370
< 0.001
 
Performed course in drug calculation
(Yes = 0a)
0.224
0.007
0.137
0.891
-1.133
-0.050
-0.834
0.405
 
Model characteristics
R = 0.719, R2 = 0.516,
Adjusted R2 = 0.494, F = 23.391
R = 0.502, R2 = 0.252,
Adjusted R2 = 0.217, F = 7.363
a Reference groups. b Standard coefficient

Discussion

Safe drug management is a multifaceted process that requires understanding and adherence to standard protocols, prescribing methods, and dosage calculation skills. Nurses play a crucial role in this process, and providing comprehensive training during their education can enhance their ability to identify risks and prevent potential problems [1]. However, few studies in Iran examine safe drug management and related skills in nursing students, and most studies in this area are related to the evaluation of medication errors and associated causes. Studies conducted in other countries have also used various tools to measure safe drug management. We used the tool developed by Fuster-Linares et al. [10] for the first time to assess safe drug management. This tool has yet to be used in other countries. Therefore, the results obtained in our study are compared with the results obtained from other tools in this field.

The self-perceptions about safe medication management

Based on our study, the average self-perception score for safe medication management was 57.65, with scores ranging from 31 to 96. The creators of the questionnaire provided only psychometric results and did not include descriptive statistics (such as means and standard deviations) for the dimensions of the questionnaire. Consequently, we were unable to make direct comparisons with their findings. Instead, we compared our results with those obtained from other assessment tools in the field. For instance, Fernandez et al. utilized a different assessment tool to measure students’ behavioral attitudes toward safe drug management, revealing moderate levels of awareness [7]. Conversely, Fusco et al. employed a competency-based assessment, which indicated that students demonstrated acceptable medication safety skills [9]. Similarly, Rezaie et al. used another instrument that showed students exhibited average skills in certain aspects of medication management while demonstrating weaknesses in others [21].
Our study indicates that nursing students in Iran may need to assume full responsibility for drug safety, which could result in a lower level of competence in safe medication management compared to newly graduated nurses [7, 22]. There is an urgent need for new educational programs that emphasize safe medication management, specifically focusing on the responsibilities of nursing students to ensure drug safety and protect patient health. Furthermore, it is crucial to acknowledge that the tool developed by Fuster-Linares et al. has not been implemented in other countries, which limits the generalizability of our findings and complicates international comparisons. Future research should seek to employ standardized tools across different contexts to facilitate more meaningful comparisons of nursing students’ competencies in safe medication management.
According to our study, the score for safety in drug prescription is 9.06 (with a score range of 0 to 16). This score reflects familiarity with drug doses, injection methods, and related concepts. A study by Sabzevari et al. [23] found that students’ knowledge of drug therapy was moderate. The study also highlighted that medication errors often occur during the drug-prescribing stage. Our findings differ from the Rezaie et al. study [21]. In a study of nursing students in Taiwan, 71% had prior experience with drug prescribing but reported low competence and high stress. Disagreement with drug prescribing responsibilities was linked to perceived competence. The study recommended implementing educational programs and guidelines at the university level to increase competence and reduce stress in drug prescription [24]. Nursing is a scientific profession that prioritizes patient care based on evidence. Nursing students must stay updated on new evidence, recommendations, and practices related to medication and management [25]. They should be familiar with medication management goals and safe practices.
The “familiarity with pharmacological concepts” was 8.65 (with a score range of 2 to 16). In the study by Caboral-Stevens et al. [26], 60% of nursing students were familiar with pharmacological concepts. However, in the survey by Hosseini et al. [27], students who underwent pharmacology simulation training had a higher level of knowledge. Insufficient pharmacological knowledge is recognized as one of the human factors related to medication errors. In addition, lack of knowledge and skills, poor experience, excessive fatigue, disregard for hospital protocols, and lack of time can lead to medication errors [4]. Our study suggests that nursing students may need more exposure to pharmacological concepts due to inadequate skill acquisition and experience. Pharmacology simulation training can help students gain the necessary knowledge and skills, ultimately reducing medication errors.
Our study indicates that the “relevance of professional practice” is 2.24 (with a score of 0.6 to 4). Nursing is crucial in this area, as nurses manage and monitor drug therapy. Specialists need to have more knowledge and commitment, particularly when it comes to administering drugs to children. The lack of quality in this process leads to instability and subsequent occurrence of undesirable events that can be avoided with preventive management interventions such as proper training [28]. Interprofessional education is proposed to influence nursing students’ attitudes and strengthen communication, collaboration, and drug safety. Implementing interprofessional education programs can play an essential role in improving the attitudes of students toward drug management and their perceived behavioral control related to safe drug management [7]. Professional practice can enhance nursing students’ attitudes toward medication management and their perceived ability to control behavior and improve communication, collaboration, and medication safety.
The factors linked with the “risk of making an error” were 8.20 (with a score range of 3 to 12). Factors such as drug reconciliation at admission and discharge, computerized physician order entry, identification of patient medications with barcodes, and reduction of nursing hours are among the factors that can effectively reduce medication errors [29]. Medication administration is complex and requires nurses to have precise knowledge and skills to prevent mistakes [7]. However, medication errors can occur due to inefficient medication management systems, environmental conditions such as noise, staff shortages, and other human-related factors such as drug knowledge, attention, lack of focus on work, and fatigue [30]. Hospitals can implement medication reconciliation, computerized provider order entry, and barcode scanning for patient medications to reduce medication errors.
The “importance of administering medication according to the prescription” was 11.88 (with a score range of 4 to 16). It is crucial to ensure the safety of patients when prescribing and receiving medication by nursing students. It must be confirmed that the prescribed medication matches the name of the medication managed by the physician [31]. Brand and generic terms may have similar prefixes, suffixes, initial letters, spellings, or similar sounds. Therefore, it is essential to differentiate between medications with similar names, as they may have different mechanisms of action or indications for prescribing [32]. Nursing students must accurately and promptly manage patients’ medications to ensure patient safety. Proper education on medication management is crucial for improving healthcare quality.
The “Verifications before drug administration” was reported at 6.48 (with a score of 1 to 12). Medication management is the nurse’s responsibility, which takes up about 40% of their time. Nurses perform the final safety check in the medication chain and are the last line of patient safety [24, 33]. Medical literature states that about one-third of all medical errors that harm hospitalized patients occur primarily in nursing activities, during the preparation and prescribing of medication [34]. Therefore, nursing students should have the necessary skills to reduce medication errors by examining the management of the clinical environment in which they work [31].
The “thinking process about medication management” was 11.13 (with a score range of 4 to 20). The thinking process includes stages such as drug preparation, drug administration, monitoring the drug’s effect, considering the patient’s condition, collecting and transferring information to the patient, reading the physician’s orders, following the drug dosage plan, and educating patients about treatment. This process requires sufficient knowledge and experience in medicine and pharmacy, and failure to adhere to it may lead to serious side effects for the patient [10]. It is said that safe drug management and prescription require more than five rights and drug management to prevent costly mistakes. Literature gradually shows more evidence that new efforts to maintain safety should highlight nurses’ clinical reasoning as an element that shapes nurses into highly skilled professionals [31]. Also, understanding students’ thinking processes during drug prescriptions is very important for preventing medication errors. Nursing education programs should correct any misconceptions or errors in students’ thinking before prescribing drugs to patients [31].

The frequency and learning of drug dose calculation

The average score for the second questionnaire, “Frequency and learning of drug dose calculation,” was 31.62 (with a range of 12–52). In the Hosseini et al. [27] study, students had an average level of medication calculations before undergoing simulation-based training. However, their medication calculation skills improved significantly after the simulation-based training course. In the Rezaie et al. [21] study, most students needed better skills in accurate medication calculation. Many medication errors occur due to a need for an understanding of drug concentrations, particularly when drugs are calculated in different ways. Errors can also arise from miscalculating the required medication dosage, students’ difficulty with mathematical calculations involving decimals and fractions, or their inability to extract conceptual information from medication dosage calculations. These issues can be influenced by insufficient education. Increasing awareness can increase accuracy in medication dosage calculation and improve safe drug management. Utilizing necessary education and awareness in medication calculations at the beginning of nursing education is of great importance so that students can benefit from it until the end of their professional careers. Therefore, nursing instructors should pay more attention to educating students about accurate medication dosage calculations.
The results of multiple regression revealed that among nursing students, an increase in overall GPA and having work experience in a hospital were associated with improved Self-perception in safe drug management and increased ability in drug dosage calculation and repetition. Additionally, an increase in age was related to improved Self-perception in safe drug management. In other words, younger nursing students with a higher overall GPA and work experience in a hospital as a student likely have better skills in safe drug management and drug dosage calculation and repetition. Previous studies have identified factors such as students’ age and previous academic success (such as high GPA) as individual factors related to nursing students’ drug calculation competence [11]. According to Gunes et al., graduate nurses have more clinical experience in prescribing, rewriting, distributing, prescribing, and monitoring drugs than final-year nursing students [35]. Therefore, the increase in medication errors by nursing students has been attributed to a need for clinical experience, knowledge, and skills [7]. Wendimeneh et al. conducted a study that found that nurses with more experience exhibited better medication management practices. These findings are consistent with our research. As individuals gain more work experience, they develop additional skills for safe drug management and become more knowledgeable about a broader range of medications, as reflected in our study’s findings [33]. Therefore, to enhance the skills of nursing students in safe drug management, they need to gain more work experience to improve their knowledge and expertise in this area.
The academic year in our study showed a positive correlation with self-perception of safe drug management and increased ability in drug dosage calculation, which was consistent with the study by Sulosaari et al. [36]. Therefore, the significant and positive relationship between academic year and Self-perception of safe drug management in nursing students indicates that students develop better abilities in safe drug management and properly implement related methods over time and progression in their education. However, the results of studies may vary based on different conditions and factors and should be further examined with greater scrutiny.

Limitations

This study was conducted among nursing students at Ardabil University of Medical Sciences. While the findings may not apply to other communities or nursing students in different environments, the use of questionnaires for data collection provides valuable insights into the experiences and perspectives of nursing students. The results can be helpful for nursing educators, policymakers, and researchers. To ensure the accuracy and reliability of the data, researchers implemented precise methods for data collection, including clear guidelines and follow-up actions. However, external factors such as participants’ circumstances or the current healthcare environment should be considered when interpreting the results.

Conclusion

Our research highlights the crucial role of nursing education in improving students’ self-perceptions and competencies in safe medication management. Key factors such as academic year, GPA, and healthcare work experience significantly impact self-perception, with final-year students demonstrating the highest confidence levels. To better prepare nursing students, educational institutions should adopt simulation-based training and interprofessional education, which promote teamwork and communication skills vital for safe medication practices. We recommend incorporating mandatory simulation sessions and collaborative workshops into nursing curricula to bridge knowledge gaps and enhance clinical outcomes.

Acknowledgements

This study has been approved by the student research committee of Ardabil University of Medical Sciences (IR.ARUMS.REC.1402.065). The authors would like to thank all the nursing students, the nursing schools affiliated with the Ardabil University of Medical Sciences and all those who helped us in this study.

Declarations

The research was conducted by ethical principles in medical research and was approved by the Ethics Committee Ardabil University of Medical Sciences (Ethics code: IR.ARUMS.REC.1402.065). Before data collection began, all participating students were provided with necessary explanations about the purpose and methods of the research. Additionally, all students were informed of their right not to participate in the study and informed written consent forms were obtained from those who wished to participate. All methods were performed following the Declaration of Helsinki.
Not Applicable.

Competing interests

The authors declare no competing interests.
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Metadaten
Titel
Assessing self-perceptions related to safe medication management among nursing students: an analytical cross-sectional study in Iran
verfasst von
Reza Nemati-Vakilabad
Maryam Hashemian
Mohammad Reza Mojebi
Alireza Mirzaei
Publikationsdatum
01.12.2025
Verlag
BioMed Central
Erschienen in
BMC Nursing / Ausgabe 1/2025
Elektronische ISSN: 1472-6955
DOI
https://doi.org/10.1186/s12912-025-02859-7