Nurses and midwives in South Africa comprise more than 56% of the total health workforce [
1]. They are central in addressing the quadruple burden of diseases: the coinciding epidemics of HIV, AIDS and tuberculosis; high maternal and child mortality; noncommunicable diseases; and violence and injuries [
2]. South Africa’s healthcare system recognizes nurses and midwives as the cornerstone of health service delivery. They are often the first and sometimes the sole interface with healthcare users, particularly at the primary healthcare level. For example, the country has the highest number of people living with HIV [
3], thus an increase in the demand for an adequate nursing and midwifery workforce to strengthen the public health sector’s response to HIV and AIDS, including initiation of antiretroviral therapy and its management at primary health care level. In addition, the Covid-19 epidemic has had an unprecedent reversal of gains in the reduction of country’s child and maternal mortality rates, which are now well behind the Sustainable Developmental Goals. Currently, the country’s institutional maternal mortality (iMMR) stands at 120 per 100,000 live births, the infant mortality rate at 25 deaths per 1,000 live births, and the institutional neonatal death rate is 12 per 1,000 live births. There is a need for massification of nurses and midwives with required skills mix for the country to combat high maternal and neonatal mortality rates [
4]. The dynamic nature of health system demands a high level of competence to meet current and future population health needs, which underscores the importance of well-prepared clinical nurse practioners. The government holds the directive to harmonise nursing programmes with service delivery and clinical competencies to conform with national practice standards [
5]. Nurse training has historically been offered under interim arrangement and not fully integrated into the post-school education system. The advent of the new National Qualifications Framework (NQF) provided an opportunity for nursing education to be integrated into the post-school education system. Hence, a policy was needed to align nursing education with post-school education legislative prescripts to foster transformative, high-quality education for nurses to effectively produce safe and competent practitioners, thus addressing population health needs [
6]. This is referred to as the National Policy on Nursing Education and Training. This policy should become the overarching framework that ensures coherent implementation of NQF-aligned nursing programmes by all providers of nursing education programmes [
7,
8]. The policy needed to undergo a robust policy development process, extensive stakeholder engagement and validation, political engagement, along with an integrated socio-economic assessment process for successful implementation. This article presents a rigorous analysis of this first national policy framework. The framework aims to ensure an inclusive and coherent approach to nursing education and training with recommendations to facilitate seamless adoption thereof.