Lebensrettende Maßnahmen bei Kindern (Paediatric Life Support, PLS)

1.

Soreide E, Morrison L, Hillman K et al (2013) The formula for survival in resuscitation. Resuscitation 84(11):1487–1493. https://doi.org/10.1016/j.resuscitation.2013.07.020CrossRefPubMed

2.

Brouwers MC, Kho ME, Browman GP et al (2010) AGREE II: advancing guideline development, reporting and evaluation in health care. J Clin Epidemiol 63(12):1308–1311. https://doi.org/10.1016/j.jclinepi.2010.07.001CrossRefPubMed

3.

Shea BJ, Hamel C, Wells GA et al (2009) AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol 62(10):1013–1020CrossRefPubMed

4.

Perkins GD, Olasveengen TM, Maconochie I et al (2018) European resuscitation council guidelines for resuscitation: 2017 update. Resuscitation 123:43–50. https://doi.org/10.1016/j.resuscitation.2017.12.007 CrossRefPubMed

5.

Perkins GD, Graesner JT, Semeraro F et al (2021) European resuscitation council guidelines 2021—executive summary. Resuscitation 161:1–60. https://doi.org/10.1016/j.resscitation.2021.02.003CrossRefPubMed

6.

Edwards-Jackson N, North K, Chiume M et al (2020) Outcomes of in-hospital paediatric cardiac arrest from a tertiary hospital in a low-income African country. Paediatr Int Child Health 40(1):11–15. https://doi.org/10.1080/20469047.2019.1570443CrossRefPubMed

7.

Nolan JP, Monsieurs KG, Bossaert L et al (2020) European Resuscitation Council COVID-19 guidelines executive summary. Resuscitation 153:45–55. https://doi.org/10.1016/j.resuscitation.2020.06.001CrossRefPubMedPubMedCentral

8.

Shen J, Sun J, Zhao D et al (2020) Characteristics of Nosocomial Infections in Children Screened for SARS-CoV‑2 Infection in China. Med Sci Monit 26:e928835. https://doi.org/10.12659/MSM.928835CrossRefPubMedPubMedCentral

9.

Ludvigsson JF (2020) Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr 109(6):1088–1095. https://doi.org/10.1111/apa.15270CrossRefPubMed

10.

Dong Y, Mo X, Hu Y et al (2020) Epidemiology of COVID-19 Among Children in China. Pediatrics. https://doi.org/10.1542/peds.2020-0702 CrossRefPubMedPubMedCentral

11.

Rauf A, Abu-Izneid T, Olatunde A et al (2020) COVID-19 pandemic: epidemiology, etiology, conventional and non-conventional therapies. Int J Environ Res Public Health. https://doi.org/10.3390/ijerph17218155 CrossRefPubMedPubMedCentral

12.

Chao JY, Derespina KR, Herold BC et al (2020) Clinical characteristics and outcomes of hospitalized and critically ill children and adolescents with Coronavirus disease 2019 at a tertiary care medical center in new York city. J Pediatr 223:14–19e2. https://doi.org/10.1016/j.jpeds.2020.05.006CrossRefPubMedPubMedCentral

13.

Garcia-Salido A, Leoz-Gordillo I, Martinez de Azagra-Garde A et al (2020) Children in critical care Due to severe acute respiratory syndrome Coronavirus 2 infection: experience in a Spanish hospital. Pediatr Crit Care Med 21(8):e576–e580. https://doi.org/10.1097/PCC.0000000000002475CrossRefPubMedPubMedCentral

14.

Nehme Z, Namachivayam S, Forrest A, Butt W, Bernard S, Smith K (2018) Trends in the incidence and outcome of paediatric out-of-hospital cardiac arrest: a 17-year observational study. Resuscitation 128:43–50. https://doi.org/10.1016/j.resuscitation.2018.04.030CrossRefPubMed

15.

Phillips RS, Scott B, Carter SJ et al (2015) Systematic review and meta-analysis of outcomes after cardiopulmonary arrest in childhood. PLoS ONE 10(6):e130327. https://doi.org/10.1371/journal.pone.0130327CrossRefPubMedPubMedCentral

16.

Gerein RB, Osmond MH, Stiell IG, Nesbitt LP, Burns S (2006) What are the etiology and epidemiology of out-of-hospital pediatric cardiopulmonary arrest in Ontario, Canada? Acad Emerg Med 13(6):653–658 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16670256)CrossRefPubMed

17.

Lee J, Yang WC, Lee EP et al (2019) Clinical survey and predictors of outcomes of pediatric out-of-hospital cardiac arrest admitted to the emergency department. Sci Rep 9(1):7032. https://doi.org/10.1038/s41598-019-43020-0CrossRefPubMedPubMedCentral

18.

Goto Y, Funada A, Goto Y (2016) Duration of prehospital cardiopulmonary resuscitation and favorable neurological outcomes for pediatric out-of-hospital cardiac arrests: a nationwide, population-based cohort study. Circulation 134(25):2046–2059. https://doi.org/10.1161/CIRCULATIONAHA.116.023821CrossRefPubMed

19.

Matsui S, Sobue T, Irisawa T et al (2020) Poor long-term survival of out-of-hospital cardiac arrest in children. Int Heart J 61(2):254–262. https://doi.org/10.1536/ihj.19-574CrossRefPubMed

20.

Okubo M, Chan HK, Callaway CW, Mann NC, Wang HE (2020) Characteristics of paediatric out-of-hospital cardiac arrest in the United States. Resuscitation 153:227–233. https://doi.org/10.1016/j.resuscitation.2020.04.023CrossRefPubMed

21.

Holmberg MJ, Ross CE, Fitzmaurice GM et al (2019) Annual incidence of adult and pediatric in-hospital cardiac arrest in the United States. Circ Cardiovasc Qual Outcomes 12(7):e005580. https://www.ncbi.nlm.nih.gov/pubmed/31545574CrossRefPubMedPubMedCentral

22.

Skellett S, Orzechowska I, Thomas K, Fortune PM (2020) The landscape of paediatric in-hospital cardiac arrest in the United Kingdom National Cardiac Arrest Audit. Resuscitation 155:165–171. https://doi.org/10.1016/j.resuscitation.2020.07.026CrossRefPubMed

23.

Booth A, Moylan A, Hodgson J et al (2018) Resuscitation registers: how many active registers are there and how many collect data on paediatric cardiac arrests? Resuscitation 129:70–75. https://doi.org/10.1016/j.resuscitation.2018.03.029CrossRefPubMed

24.

Weiss SL, Peters MJ, Alhazzani W et al (2020) Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med 21(2):e52–e106. https://doi.org/10.1097/PCC.0000000000002198CrossRefPubMed

25.

Hamid MA, Chandna A, Siddiqui S, Fayyaz J (2016) Pulse oximetry: a reliable and cost effective screening tool in children with pneumonia for developing countries. J Pak Med Assoc 66(8):1015–1018 (https://www.ncbi.nlm.nih.gov/pubmed/27524539)PubMed

26.

Bamber AR, Mifsud W, Wolfe I et al (2015) Potentially preventable infant and child deaths identified at autopsy; findings and implications. Forensic Sci Med Pathol 11(3):358–364. https://doi.org/10.1007/s12024-015-9681-9CrossRefPubMed

27.

Hansmann A, Morrow BM, Lang HJ (2017) Review of supplemental oxygen and respiratory support for paediatric emergency care in sub-Saharan Africa. Afr J Emerg Med 7(Suppl):S10–S19. https://doi.org/10.1016/j.afjem.2017.10.001CrossRefPubMedPubMedCentral

28.

Mendelson J (2018) Emergency department management of pediatric shock. Emerg Med Clin North Am 36(2):427–440. https://doi.org/10.1016/j.emc.2017.12.010CrossRefPubMed

29.

Davis AL, Carcillo JA, Aneja RK et al (2017) American college of critical care medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. Crit Care Med 45(6):1061–1093. https://doi.org/10.1097/CCM.0000000000002425CrossRefPubMed

30.

Rambaud-Althaus C, Althaus F, Genton B, D’Acremont V (2015) Clinical features for diagnosis of pneumonia in children younger than 5 years: a systematic review and meta-analysis. Lancet Infect Dis 15(4):439–450. https://doi.org/10.1016/S1473-3099(15)70017-4CrossRefPubMed

31.

Opiyo N, English M (2011) What clinical signs best identify severe illness in young infants aged 0–59 days in developing countries? A systematic review. Arch Dis Child 96(11):1052–1059. https://doi.org/10.1136/adc.2010.186049CrossRefPubMed

32.

Acker SN, Ross JT, Partrick DA, Tong S, Bensard DD (2015) Pediatric specific shock index accurately identifies severely injured children. J Pediatr Surg 50(2):331–334. https://doi.org/10.1016/j.jpedsurg.2014.08.009CrossRefPubMed

33.

Rousseaux J, Grandbastien B, Dorkenoo A, Lampin ME, Leteurtre S, Leclerc F (2013) Prognostic value of shock index in children with septic shock. Pediatr Emerg Care 29(10):1055–1059. https://doi.org/10.1097/PEC.0b013e3182a5c99cCrossRefPubMed

34.

Strutt J, Flood A, Kharbanda AB (2019) Shock index as a predictor of morbidity and mortality in pediatric trauma patients. Pediatr Emerg Care 35(2):132–137. https://doi.org/10.1097/PEC.0000000000001733CrossRefPubMed

35.

Shah S, Kaul A, Jadhav Y, Shiwarkar G (2020) Clinical outcome of severe sepsis and septic shock in critically ill children. Trop Doct 50(3):186–190. https://doi.org/10.1177/0049475520914831CrossRefPubMed

36.

Krishnan SG, Wong HC, Ganapathy S, Ong GY (2020) Oximetry-detected pulsus paradoxus predicts for severity in paediatric asthma. Arch Dis Child 105(6):533–538. https://doi.org/10.1136/archdischild-2019-318043CrossRef

37.

Fleming S, Gill P, Jones C et al (2015) The diagnostic value of capillary refill time for detecting serious illness in children: a systematic review and meta-analysis. PLoS ONE 10(9):e138155. https://doi.org/10.1371/journal.pone.0138155CrossRefPubMedPubMedCentral

38.

Scott HF, Deakyne SJ, Woods JM, Bajaj L (2015) The prevalence and diagnostic utility of systemic inflammatory response syndrome vital signs in a pediatric emergency department. Acad Emerg Med 22(4):381–389. https://doi.org/10.1111/acem.12610CrossRefPubMed

39.

Brissaud O, Botte A, Cambonie G et al (2016) Experts’ recommendations for the management of cardiogenic shock in children. Ann Intensive Care 6(1):14. https://doi.org/10.1186/s13613-016-0111-2CrossRefPubMedPubMedCentral

40.

Paul R (2018) Recognition, diagnostics, and management of pediatric severe sepsis and septic shock in the emergency department. Pediatr Clin North Am 65(6):1107–1118. https://doi.org/10.1016/j.pcl.2018.07.012CrossRefPubMed

41.

Blacklock C, Mayon-White R, Coad N, Thompson M (2011) Which symptoms and clinical features correctly identify serious respiratory infection in children attending a paediatric assessment unit? Arch Dis Child 96(8):708–714. https://doi.org/10.1136/adc.2010.206243CrossRefPubMed

42.

Daw WJ, Kingshott RN, Elphick HE (2017) Poor inter-observer agreement in the measurement of respiratory rate in children: a prospective observational study. BMJ Paediatr Open 1(1):e173. https://doi.org/10.1136/bmjpo-2017-000173CrossRefPubMedPubMedCentral

43.

Wang EE, Law BJ, Stephens D et al (1996) Study of interobserver reliability in clinical assessment of RSV lower respiratory illness: a Pediatric Investigators Collaborative Network for Infections in Canada (PICNIC) study. Pediatr Pulmonol 22(1):23–27. https://doi.org/10.1002/(SICI)1099-0496(199607)22:1〈23::AID-PPUL4〉3.0.CO;2‑LCrossRefPubMed

44.

Kemper KJ, Benson MS, Bishop MJ (1992) Interobserver variability in assessing pediatric postextubation stridor. Clin Pediatr 31(7):405–408. https://doi.org/10.1177/000992289203100705CrossRef

45.

de Groot MG, de Neef M, Otten MH, van Woensel JBM, Bem RA (2020) Interobserver agreement on clinical judgment of work of breathing in spontaneously breathing children in the pediatric intensive care unit. J Pediatr Intensive Care 9(1):34–39. https://doi.org/10.1055/s-0039-1697679CrossRefPubMed

46.

Balamuth F, Alpern ER, Grundmeier RW et al (2015) Comparison of two sepsis recognition methods in a pediatric emergency department. Acad Emerg Med 22(11):1298–1306. https://doi.org/10.1111/acem.12814CrossRefPubMedPubMedCentral

47.

Despins LA (2017) Automated detection of sepsis using electronic medical record data: a systematic review. J Healthc Qual 39(6):322–333. https://doi.org/10.1097/JHQ.0000000000000066CrossRefPubMed

48.

Potes C, Conroy B, Xu-Wilson M, Newth C, Inwald D, Frassica J (2017) A clinical prediction model to identify patients at high risk of hemodynamic instability in the pediatric intensive care unit. Crit Care 21(1):282. https://doi.org/10.1186/s13054-017-1874-zCrossRefPubMedPubMedCentral

49.

Fernandez A, Benito J, Mintegi S (2017) Is this child sick? Usefulness of the pediatric assessment triangle in emergency settings. J Pediatr 93(Suppl 1):60–67. https://doi.org/10.1016/j.jped.2017.07.002CrossRef

50.

Horeczko T, Enriquez B, McGrath NE, Gausche-Hill M, Lewis RJ (2013) The pediatric assessment triangle: accuracy of its application by nurses in the triage of children. J Emerg Nurs 39(2):182–189. https://doi.org/10.1016/j.jen.2011.12.020CrossRefPubMed

51.

Gausche-Hill M, Eckstein M, Horeczko T et al (2014) Paramedics accurately apply the pediatric assessment triangle to drive management. Prehosp Emerg Care 18(4):520–530. https://doi.org/10.3109/10903127.2014.912706CrossRefPubMed

52.

Fernandez A, Ares MI, Garcia S, Martinez-Indart L, Mintegi S, Benito J (2017) The validity of the pediatric assessment triangle as the first step in the triage process in a pediatric emergency department. Pediatr Emerg Care 33(4):234–238. https://doi.org/10.1097/PEC.0000000000000717CrossRefPubMed

53.

Fleming S, Thompson M, Stevens R et al (2011) Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies. Lancet 377(9770):1011–1018. https://doi.org/10.1016/S0140-6736(10)62226-XCrossRefPubMedPubMedCentral

54.

O’Leary F, Hayen A, Lockie F, Peat J (2015) Defining normal ranges and centiles for heart and respiratory rates in infants and children: a cross-sectional study of patients attending an Australian tertiary hospital paediatric emergency department. Arch Dis Child 100(8):733–737. https://doi.org/10.1136/archdischild-2014-307401CrossRefPubMed

55.

Sepanski RJ, Godambe SA, Zaritsky AL (2018) Pediatric vital sign distribution derived from a multi-centered emergency department database. Front Pediatr 6:66. https://doi.org/10.3389/fped.2018.00066CrossRefPubMedPubMedCentral

56.

Nijman RG, Thompson M, van Veen M, Perera R, Moll HA, Oostenbrink R (2012) Derivation and validation of age and temperature specific reference values and centile charts to predict lower respiratory tract infection in children with fever: prospective observational study. BMJ 345:e4224. https://doi.org/10.1136/bmj.e4224CrossRefPubMedPubMedCentral

57.

Hagedoorn NN, Zachariasse JM, Moll HA (2019) A comparison of clinical paediatric guidelines for hypotension with population-based lower centiles: a systematic review. Crit Care 23(1):380. https://doi.org/10.1186/s13054-019-2653-9CrossRefPubMedPubMedCentral

58.

Haque IU, Zaritsky AL (2007) Analysis of the evidence for the lower limit of systolic and mean arterial pressure in children. Pediatr Crit Care Med 8(2):138–144. https://doi.org/10.1097/01.PCC.0000257039.32593.DC (In eng)CrossRefPubMed

59.

Eytan D, Goodwin AJ, Greer R, Guerguerian AM, Laussen PC (2017) Heart rate and blood pressure centile curves and distributions by age of hospitalized critically ill children. Front Pediatr 5:52. https://doi.org/10.3389/fped.2017.00052CrossRefPubMedPubMedCentral

60.

Jackson LV, Thalange NK, Cole TJ (2007) Blood pressure centiles for Great Britain. Arch Dis Child 92(4):298–303. https://doi.org/10.1136/adc.2005.081216CrossRefPubMed

61.

Xi B, Zong X, Kelishadi R et al (2016) Establishing international blood pressure references among nonoverweight children and adolescents aged 6 to 17 years. Circulation 133(4):398–408. https://doi.org/10.1161/CIRCULATIONAHA.115.017936CrossRefPubMed

62.

Duke T, Blaschke AJ, Sialis S, Bonkowsky JL (2002) Hypoxaemia in acute respiratory and non-respiratory illnesses in neonates and children in a developing country. Arch Dis Child 86(2):108–112. https://doi.org/10.1136/adc.86.2.108CrossRefPubMedPubMedCentral

63.

Salyer JW (2003) Neonatal and pediatric pulse oximetry. Respir Care 48(4):386–396 (discussion 397–8)PubMed

64.

Tobin MJ, Laghi F, Jubran A (2020) Why COVID-19 silent hypoxemia is baffling to physicians. Am J Respir Crit Care Med 202(3):356–360. https://doi.org/10.1164/rccm.202006-2157CPCrossRefPubMedPubMedCentral

65.

Weber MW, Usen S, Palmer A, Jaffar S, Mulholland EK (1997) Predictors of hypoxaemia in hospital admissions with acute lower respiratory tract infection in a developing country. Arch Dis Child 76(4):310–314. https://doi.org/10.1136/adc.76.4.310CrossRefPubMedPubMedCentral

66.

Aubertin G, Marguet C, Delacourt C et al (2012) Recommendations for pediatric oxygen therapy in acute and chronic settings: needs assessment, implementation criteria, prescription practices and follow-up. Arch Pediatr 19(5):528–536. https://doi.org/10.1016/j.arcped.2012.02.016CrossRefPubMed

67.

Carruthers DM, Harrison BD (1995) Arterial blood gas analysis or oxygen saturation in the assessment of acute asthma? Thorax 50(2):186–188. https://doi.org/10.1136/thx.50.2.186CrossRefPubMedPubMedCentral

68.

Kobayashi M, Fukuda S, Takano KI, Kamizono J, Ichikawa K (2018) Can a pulse oxygen saturation of 95 % to 96 % help predict further vital sign destabilization in school-aged children?: a retrospective observational study. Medicine 97(25):e11135. https://doi.org/10.1097/MD.0000000000011135CrossRefPubMedPubMedCentral

69.

Shah SN, Bachur RG, Simel DL, Neuman MI (2017) Does this child have pneumonia?: the rational clinical examination systematic review. JAMA 318(5):462–471. https://doi.org/10.1001/jama.2017.9039CrossRefPubMed

70.

Ozdemir A, Dogruel D, Yilmaz O (2017) Oxygen saturation/minute heart rate index: simple lung function test for children. Pediatr Int 59(2):209–212. https://doi.org/10.1111/ped.13081CrossRefPubMed

71.

Crocker ME, Hossen S, Goodman D et al (2020) Effects of high altitude on respiratory rate and oxygen saturation reference values in healthy infants and children younger than 2 years in four countries: a cross-sectional study. Lancet Glob Health 8(3):e362–e373. https://doi.org/10.1016/S2214-109X(19)30543-1CrossRefPubMedPubMedCentral

72.

Abramo TJ, Wiebe RA, Scott S, Goto CS, McIntire DD (1997) Noninvasive capnometry monitoring for respiratory status during pediatric seizures. Crit Care Med 25(7):1242–1246. https://doi.org/10.1097/00003246-199707000-00029CrossRefPubMed

73.

Langhan ML, Shabanova V, Li FY, Bernstein SL, Shapiro ED (2015) A randomized controlled trial of capnography during sedation in a pediatric emergency setting. Am J Emerg Med 33(1):25–30. https://doi.org/10.1016/j.ajem.2014.09.050CrossRefPubMed

74.

Moses JM, Alexander JL, Agus MS (2009) The correlation and level of agreement between end-tidal and blood gas pCO2 in children with respiratory distress: a retrospective analysis. BMC Pediatr 9:20. https://doi.org/10.1186/1471-2431-9-20CrossRefPubMedPubMedCentral

75.

Abramo TJ, Wiebe RA, Scott SM, Primm PA, McIntyre D, Mydler T (1996) Noninvasive capnometry in a pediatric population with respiratory emergencies. Pediatr Emerg Care 12(4):252–254. https://doi.org/10.1097/00006565-199608000-00004CrossRefPubMed

76.

Langhan ML, Emerson BL, Nett S et al (2018) End-tidal carbon dioxide use for tracheal Intubation: analysis from the national emergency airway registry for children (NEAR4KIDS) registry. Pediatr Crit Care Med 19(2):98–105. https://doi.org/10.1097/PCC.0000000000001372CrossRefPubMed

77.

Phillips JS, Pangilinan LP, Mangalindan ER, Booze JL, Kallet RH (2017) A comparison of different techniques for interfacing capnography with adult and pediatric supplemental oxygen masks. Respir Care 62(1):78–85. https://doi.org/10.4187/respcare.05111CrossRefPubMed

78.

Saunders R, Struys M, Pollock RF, Mestek M, Lightdale JR (2017) Patient safety during procedural sedation using capnography monitoring: a systematic review and meta-analysis. BMJ Open 7(6):e13402. https://doi.org/10.1136/bmjopen-2016-013402CrossRefPubMedPubMedCentral

79.

Langhan ML, Chen L, Marshall C, Santucci KA (2011) Detection of hypoventilation by capnography and its association with hypoxia in children undergoing sedation with ketamine. Pediatr Emerg Care 27(5):394–397. https://doi.org/10.1097/PEC.0b013e318217b538CrossRefPubMed

80.

Yang JT, Erickson SL, Killien EY, Mills B, Lele AV, Vavilala MS (2019) Agreement between arterial carbon dioxide levels with end-tidal carbon dioxide levels and associated factors in children hospitalized with traumatic brain injury. JAMA Netw Open 2(8):e199448. https://doi.org/10.1001/jamanetworkopen.2019.9448CrossRefPubMedPubMedCentral

81.

Scott HF, Brou L, Deakyne SJ, Kempe A, Fairclough DL, Bajaj L (2017) Association between early lactate levels and 30-day mortality in clinically suspected sepsis in children. JAMA Pediatr 171(3):249–255. https://doi.org/10.1001/jamapediatrics.2016.3681CrossRefPubMed

82.

Scott HF, Donoghue AJ, Gaieski DF, Marchese RF, Mistry RD (2012) The utility of early lactate testing in undifferentiated pediatric systemic inflammatory response syndrome. Acad Emerg Med 19(11):1276–1280. https://doi.org/10.1111/acem.12014CrossRefPubMed

83.

Miescier MJ, Lane RD, Sheng X, Larsen GY (2019) Association between initial emergency department lactate and use of vasoactive medication in children with septic shock. Pediatr Emerg Care 35(7):455–460. https://doi.org/10.1097/PEC.0000000000000981CrossRefPubMed

84.

Yan HP, Lu XL, Qiu J, Liu PP, Zuo C, Zhu YM (2016) Value of blood lactic acid in evaluating disease severity and prognosis in children with sepsis. Zhongguo Dang Dai Er Ke Za Zhi 18(6):506–510 (www.ncbi.nlm.nih.gov/pubmed/27324538))PubMed

85.

Scott HF, Brou L, Deakyne SJ, Fairclough DL, Kempe A, Bajaj L (2016) Lactate clearance and normalization and prolonged organ dysfunction in pediatric sepsis. J Pediatr 170:149–155.e1–4. https://doi.org/10.1016/j.jpeds.2015.11.071CrossRefPubMed

86.

Britton PN, Eastwood K, Paterson B et al (2015) Consensus guidelines for the investigation and management of encephalitis in adults and children in Australia and New Zealand. Intern Med J 45(5):563–576. https://doi.org/10.1111/imj.12749CrossRefPubMed

87.

Kneen R, Michael BD, Menson E et al (2012) Management of suspected viral encephalitis in children—Association of British Neurologists and British Paediatric Allergy, Immunology and Infection Group national guidelines. J Infect 64(5):449–477. https://doi.org/10.1016/j.jinf.2011.11.013CrossRefPubMed

88.

Thompson M, Van den Bruel A, Verbakel J et al (2012) Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care. Health Technol Assess 16(15):1–100. https://doi.org/10.3310/hta16150CrossRefPubMedPubMedCentral

89.

Da Dalt L, Parri N, Amigoni A et al (2018) Italian guidelines on the assessment and management of pediatric head injury in the emergency department. Ital J Pediatr 44(1):7. https://doi.org/10.1186/s13052-017-0442-0CrossRefPubMedPubMedCentral

90.

Medley TL, Miteff C, Andrews I et al (2019) Australian clinical consensus guideline: the diagnosis and acute management of childhood stroke. Int J Stroke 14(1):94–106. https://doi.org/10.1177/1747493018799958CrossRefPubMed

91.

Chou R, Totten AM, Carney N et al (2017) Predictive utility of the total Glasgow coma scale versus the motor component of the glasgow coma scale for identification of patients with serious traumatic injuries. Ann Emerg Med 70(2):143–157.e6. https://doi.org/10.1016/j.annemergmed.2016.11.032CrossRefPubMed

92.

Nuttall AG, Paton KM, Kemp AM (2018) To what extent are GCS and AVPU equivalent to each other when assessing the level of consciousness of children with head injury? A cross-sectional study of UK hospital admissions. BMJ Open 8(11):e23216. https://doi.org/10.1136/bmjopen-2018-023216CrossRefPubMedPubMedCentral

93.

Hoffmann F, Schmalhofer M, Lehner M, Zimatschek S, Grote V, Reiter K (2016) Comparison of the AVPU scale and the pediatric GCS in prehospital setting. Prehosp Emerg Care 20(4):493–498. https://doi.org/10.3109/10903127.2016.1139216CrossRefPubMed

94.

Van de Voorde P, Sabbe M, Rizopoulos D et al (2008) Assessing the level of consciousness in children: a plea for the Glasgow Coma Motor subscore. Resuscitation 76(2):175–179. https://doi.org/10.1016/j.resuscitation.2007.07.007CrossRefPubMed

95.

Borgialli DA, Mahajan P, Hoyle JD Jr. et al (2016) Performance of the pediatric Glasgow coma scale score in the evaluation of children with blunt head trauma. Acad Emerg Med 23(8):878–884. https://doi.org/10.1111/acem.13014CrossRefPubMed

96.

DiBrito SR, Cerullo M, Goldstein SD, Ziegfeld S, Stewart D, Nasr IW (2018) Reliability of Glasgow Coma Score in pediatric trauma patients. J Pediatr Surg 53(9):1789–1794. https://doi.org/10.1016/j.jpedsurg.2017.12.027CrossRefPubMed

97.

Ladner TR, Mahdi J, Gindville MC et al (2015) Pediatric acute stroke protocol activation in a children’s hospital emergency department. Stroke 46(8):2328–2331. https://doi.org/10.1161/STROKEAHA.115.009961CrossRefPubMed

98.

DeLaroche AM, Sivaswamy L, Farooqi A, Kannikeswaran N (2016) Pediatric stroke clinical pathway improves the time to diagnosis in an emergency department. Pediatr Neurol 65:39–44. https://doi.org/10.1016/j.pediatrneurol.2016.09.005CrossRefPubMed

99.

Yock-Corrales A, Mackay MT, Mosley I, Maixner W, Babl FE (2011) Acute childhood arterial ischemic and hemorrhagic stroke in the emergency department. Ann Emerg Med 58(2):156–163. https://doi.org/10.1016/j.annemergmed.2010.10.013CrossRefPubMed

100.

Gumer LB, Del Vecchio M, Aronoff S (2014) Strokes in children: a systematic review. Pediatr Emerg Care 30(9):660–664. https://doi.org/10.1097/PEC.0000000000000218CrossRefPubMed

101.

Mackay MT, Monagle P, Babl FE (2016) Brain attacks and stroke in children. J Paediatr Child Health 52(2):158–163. https://doi.org/10.1111/jpc.13086CrossRefPubMed

102.

Guedj R, Chappuy H, Titomanlio L et al (2015) Risk of bacterial meningitis in children 6 to 11 months of age with a first simple febrile seizure: a retrospective, cross-sectional, observational study. Acad Emerg Med 22(11):1290–1297. https://doi.org/10.1111/acem.12798CrossRefPubMed

103.

Najaf-Zadeh A, Dubos F, Hue V, Pruvost I, Bennour A, Martinot A (2013) Risk of bacterial meningitis in young children with a first seizure in the context of fever: a systematic review and meta-analysis. PLoS ONE 8(1):e55270. https://doi.org/10.1371/journal.pone.0055270CrossRefPubMedPubMedCentral

104.

Joffe AR, Anton NR, Burkholder SC (2011) Reduction in hospital mortality over time in a hospital without a pediatric medical emergency team: limitations of before-and-after study designs. Arch Pediatr Adolesc Med 165(5):419–423. https://doi.org/10.1001/archpediatrics.2011.47CrossRefPubMed

105.

Thomas-Jones E, Lloyd A, Roland D et al (2018) A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system—utilisation and mortality avoidance—the PUMA study protocol. BMC Pediatr 18(1):244. https://doi.org/10.1186/s12887-018-1210-zCrossRefPubMedPubMedCentral

106.

Bortcosh W, Shaahinfar A, Sojar S, Klig JE (2018) New directions in point-of-care ultrasound at the crossroads of paediatric emergency and critical care. Curr Opin Pediatr 30(3):350–358. https://doi.org/10.1097/MOP.0000000000000621CrossRefPubMed

107.

Singh Y, Tissot C, Fraga MV et al (2020) International evidence-based guidelines on Point of Care Ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC). Crit Care 24(1):65. https://doi.org/10.1186/s13054-020-2787-9CrossRefPubMedPubMedCentral

108.

Marin JR, Abo AM, Arroyo AC et al (2016) Pediatric emergency medicine point-of-care ultrasound: summary of the evidence. Crit Ultrasound J 8(1):16. https://doi.org/10.1186/s13089-016-0049-5CrossRefPubMedPubMedCentral

109.

Balk DS, Lee C, Schafer J et al (2018) Lung ultrasound compared to chest X‑ray for diagnosis of pediatric pneumonia: a meta-analysis. Pediatr Pulmonol 53(8):1130–1139. https://doi.org/10.1002/ppul.24020CrossRefPubMed

110.

Orso D, Ban A, Guglielmo N (2018) Lung ultrasound in diagnosing pneumonia in childhood: a systematic review and meta-analysis. J Ultrasound 21(3):183–195. https://doi.org/10.1007/s40477-018-0306-5CrossRefPubMedPubMedCentral

111.

Potter SK, Griksaitis MJ (2019) The role of point-of-care ultrasound in pediatric acute respiratory distress syndrome: emerging evidence for its use. Ann Transl Med 7(19):507. https://doi.org/10.21037/atm.2019.07.76CrossRefPubMedPubMedCentral

112.

Ozkaya AK, Baskan Vuralkan F, Ardic S (2019) Point-of-care lung ultrasound in children with non-cardiac respiratory distress or tachypnea. Am J Emerg Med 37(11):2102–2106. https://doi.org/10.1016/j.ajem.2019.05.063CrossRefPubMed

113.

Lissaman C, Kanjanauptom P, Ong C, Tessaro M, Long E, O’Brien A (2019) Prospective observational study of point-of-care ultrasound for diagnosing pneumonia. Arch Dis Child 104(1):12–18. https://doi.org/10.1136/archdischild-2017-314496CrossRefPubMed

114.

Harel-Sterling M, Diallo M, Santhirakumaran S, Maxim T, Tessaro M (2019) Emergency department resource use in pediatric pneumonia: point-of-care lung ultrasonography versus chest radiography. J Ultrasound Med 38(2):407–414. https://doi.org/10.1002/jum.14703CrossRefPubMed

115.

Jones BP, Tay ET, Elikashvili I et al (2016) Feasibility and safety of substituting lung ultrasonography for chest radiography when diagnosing pneumonia in children: a randomized controlled trial. Chest 150(1):131–138. https://doi.org/10.1016/j.chest.2016.02.643CrossRefPubMed

116.

Berce V, Tomazin M, Gorenjak M, Berce T, Lovrencic B (2019) The usefulness of lung ultrasound for the aetiological diagnosis of community-acquired pneumonia in children. Sci Rep 9(1):17957. https://doi.org/10.1038/s41598-019-54499-yCrossRefPubMedPubMedCentral

117.

Lovrenski J, Petrovic S, Balj-Barbir S, Jokic R, Vilotijevic-Dautovic G (2016) Stethoscope vs. ultrasound probe—which is more reliable in children with suspected pneumonia? Acta Med Acad 45(1):39–50. https://doi.org/10.5644/ama2006-124.155CrossRefPubMed

118.

Gravel CA, Monuteaux MC, Levy JA, Miller AF, Vieira RL, Bachur RG (2020) Interrater reliability of pediatric point-of-care lung ultrasound findings. Am J Emerg Med 38(1):1–6. https://doi.org/10.1016/j.ajem.2019.01.047CrossRefPubMed

119.

Lin MJ, Gurley K, Hoffmann B (2016) Bedside ultrasound for tracheal tube verification in pediatric emergency department and ICU patients: a systematic review. Pediatr Crit Care Med 17(10):e469–e476. https://doi.org/10.1097/PCC.0000000000000907CrossRefPubMed

120.

Mori T, Nomura O, Hagiwara Y, Inoue N (2019) Diagnostic accuracy of a 3-point ultrasound protocol to detect esophageal or endobronchial mainstem intubation in a pediatric emergency department. J Ultrasound Med 38(11):2945–2954. https://doi.org/10.1002/jum.15000CrossRefPubMed

121.

Klugman D, Berger JT (2016) Echocardiography and focused cardiac ultrasound. Pediatr Crit Care Med 17(8 Suppl 1):S222–S224. https://doi.org/10.1097/PCC.0000000000000815CrossRefPubMedPubMedCentral

122.

Long E, Oakley E, Duke T, Babl FE, Paediatric Research in Emergency Departments International C (2017) Does respiratory variation in inferior vena cava diameter predict fluid responsiveness: a systematic review and meta-analysis. Shock 47(5):550–559. https://doi.org/10.1097/SHK.0000000000000801CrossRefPubMed

123.

Orso D, Paoli I, Piani T, Cilenti FL, Cristiani L, Guglielmo N (2020) Accuracy of ultrasonographic measurements of inferior vena cava to determine fluid responsiveness: a systematic review and meta-analysis. J Intensive Care Med 35(4):354–363. https://doi.org/10.1177/0885066617752308CrossRefPubMed

124.

Long E, O’Brien A, Duke T, Oakley E, Babl FE, Paediatric Research in Emergency Departments International C (2019) Effect of fluid bolus therapy on extravascular lung water measured by lung ultrasound in children with a presumptive clinical diagnosis of sepsis. J Ultrasound Med 38(6):1537–1544. https://doi.org/10.1002/jum.14842CrossRefPubMed

125.

Ricci F, Aquilani R, Radico F et al (2015) Role and importance of ultrasound lung comets in acute cardiac care. Eur Heart J Acute Cardiovasc Care 4(2):103–112. https://doi.org/10.1177/2048872614553166CrossRefPubMed

126.

Holmes JF, Gladman A, Chang CH (2007) Performance of abdominal ultrasonography in pediatric blunt trauma patients: a meta-analysis. J Pediatr Surg 42(9):1588–1594. https://doi.org/10.1016/j.jpedsurg.2007.04.023CrossRefPubMed

127.

Holmes JF, Kelley KM, Wootton-Gorges SL et al (2017) Effect of abdominal ultrasound on clinical care, outcomes, and resource use among children with blunt torso trauma: a randomized clinical trial. JAMA 317(22):2290–2296. https://doi.org/10.1001/jama.2017.6322CrossRefPubMedPubMedCentral

128.

Schoneberg C, Tampier S, Hussmann B, Lendemans S, Waydhas C (2014) Diagnostic management in paediatric blunt abdominal trauma—a systematic review with metaanalysis. Zentralbl Chir 139(6):584–591. https://doi.org/10.1055/s-0032-1328645CrossRefPubMed

129.

Greif R, Bhanji F, Bigham BL et al (2020) Education, Implementation, and Teams: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Resuscitation 156:A188–A239. https://doi.org/10.1016/j.resuscitation.2020.09.014CrossRefPubMed

130.

Weinstock P, Halamek LP (2008) Teamwork during resuscitation. Pediatr Clin North Am 55(4):1011–1024, xi–xii. https://doi.org/10.1016/j.pcl.2008.04.001CrossRefPubMed

131.

Cheng A, Duff JP, Kessler D et al (2018) Optimizing CPR performance with CPR coaching for pediatric cardiac arrest: a randomized simulation-based clinical trial. Resuscitation 132:33–40. https://doi.org/10.1016/j.resuscitation.2018.08.021CrossRefPubMed

132.

Sherman JM, Chang TP, Ziv N, Nager AL (2020) Barriers to effective teamwork relating to pediatric resuscitations: perceptions of pediatric emergency medicine staff. Pediatr Emerg Care 36(3):e146–e150. https://doi.org/10.1097/PEC.0000000000001275CrossRefPubMed

133.

Coolen E, Draaisma J, Loeffen J (2019) Measuring situation awareness and team effectiveness in pediatric acute care by using the situation global assessment technique. Eur J Pediatr 178(6):837–850. https://doi.org/10.1007/s00431-019-03358-zCrossRefPubMedPubMedCentral

134.

Lammers RL, Willoughby-Byrwa M, Fales WD (2014) Errors and error-producing conditions during a simulated, prehospital, pediatric cardiopulmonary arrest. Simul Healthc 9(3):174–183. https://doi.org/10.1097/SIH.0000000000000013CrossRefPubMed

135.

Taylor KL, Ferri S, Yavorska T, Everett T, Parshuram C (2014) A description of communication patterns during CPR in ICU. Resuscitation 85(10):1342–1347. https://doi.org/10.1016/j.resuscitation.2014.06.027CrossRefPubMed

136.

Grimsley EA, Cochrane NH, Keane RR, Sumner BD, Mullan PC, O’Connell KJ (2019) A pulse check on leadership and teamwork: an evaluation of the first 5 minutes of emergency department resuscitation during pediatric cardiopulmonary arrests. Pediatr Emerg Care. https://doi.org/10.1097/PEC.0000000000001923CrossRef

137.

AlSohime F, NurHussen A, Temsah MH et al (2018) Factors that influence the self-reported confidence of pediatric residents as team leaders during cardiopulmonary resuscitation: a national survey. Int J Pediatr Adolesc Med 5(3):116–121. https://doi.org/10.1016/j.ijpam.2018.07.001CrossRefPubMedPubMedCentral

138.

Delaloye NJ, Tobler K, O’Neill T et al (2020) Errors during resuscitation: the impact of perceived authority on delivery of care. J Patient Saf 16(1):73–78. https://doi.org/10.1097/PTS.0000000000000359CrossRefPubMed

139.

Fernandez Castelao E, Russo SG, Riethmuller M, Boos M (2013) Effects of team coordination during cardiopulmonary resuscitation: a systematic review of the literature. J Crit Care 28(4):504–521. https://doi.org/10.1016/j.jcrc.2013.01.005CrossRefPubMed

140.

Riskin A, Bamberger P, Erez A et al (2019) Expressions of gratitude and medical team performance. Pediatrics. https://doi.org/10.1542/peds.2018-2043CrossRefPubMed

141.

Krage R, Zwaan L, Tjon Soei LL et al (2017) Relationship between non-technical skills and technical performance during cardiopulmonary resuscitation: does stress have an influence? Emerg Med Clin North Am 34(11):728–733. https://doi.org/10.1136/emermed-2016-205754CrossRef

142.

Johnson SL, Haerling KA, Yuwen W, Huynh V, Le C (2020) Incivility and clinical performance, teamwork, and emotions: a randomized controlled trial. J Nurs Care Qual 35(1):70–76. https://doi.org/10.1097/NCQ.0000000000000407CrossRefPubMed

143.

Maconochie IK, Aickin R, Hazinski MF et al (2020) Pediatric life support: 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 156:A120–A155. https://doi.org/10.1016/j.resuscitation.2020.09.013CrossRefPubMedPubMedCentral

144.

Wells M, Goldstein LN, Bentley A, Basnett S, Monteith I (2017) The accuracy of the Broselow tape as a weight estimation tool and a drug-dosing guide—a systematic review and meta-analysis. Resuscitation 121:9–33. https://doi.org/10.1016/j.resuscitation.2017.09.026CrossRefPubMed

145.

Wells M, Goldstein LN, Bentley A (2017) The accuracy of emergency weight estimation systems in children—a systematic review and meta-analysis. Int J Emerg Med 10(1):29. https://doi.org/10.1186/s12245-017-0156-5CrossRefPubMedPubMedCentral

146.

Young KD, Korotzer NC (2016) Weight estimation methods in children: a systematic review. Ann Emerg Med 68(4):441–451.e10. https://doi.org/10.1016/j.annemergmed.2016.02.043CrossRefPubMed

147.

Matson KL, Horton ER, Capino AC (2017) Advocacy committee for the pediatric pharmacy advocacy G. medication dosage in overweight and obese children. J Pediatr Pharmacol Ther 22(1):81–83. https://doi.org/10.5863/1551-6776-22.1.81CrossRefPubMedPubMedCentral

148.

Rodriguez JJ, Higuita-Gutierrez LF, Carrillo Garcia EA, Castano Betancur E, Londono LM, Restrepo Vargas S (2020) meta-analysis of failure of prehospital endotracheal Intubation in pediatric patients. Emerg Med Int. https://doi.org/10.1155/2020/7012508CrossRefPubMedPubMedCentral

149.

Harshman J, Roy M, Cartotto R (2019) Emergency care of the burn patient before the burn center: a systematic review and meta-analysis. J Burn Care Res 40(2):166–188. https://doi.org/10.1093/jbcr/iry060CrossRefPubMed

150.

Garner AA, Bennett N, Weatherall A, Lee A (2020) Success and complications by team composition for prehospital paediatric intubation: a systematic review and meta-analysis. Crit Care 24(1):149. https://doi.org/10.1186/s13054-020-02865-yCrossRefPubMedPubMedCentral

151.

Miller KA, Nagler J (2019) Advances in emergent airway management in pediatrics. Emerg Med Clin North Am 37(3):473–491. https://doi.org/10.1016/j.emc.2019.03.006CrossRefPubMed

152.

Stein ML, Park RS, Kovatsis PG (2020) Emerging trends, techniques, and equipment for airway management in pediatric patients. Paediatr Anaesth 30(3):269–279. https://doi.org/10.1111/pan.13814CrossRefPubMed

153.

Sun F, Wang Y, Ma S et al (2017) Clinical consensus of emergency airway management. J Thorac Dis 9(11):4599–4606. https://doi.org/10.21037/jtd.2017.10.79CrossRefPubMedPubMedCentral

154.

Engelhardt T, Fiadjoe JE, Weiss M et al (2019) A framework for the management of the pediatric airway. Paediatr Anaesth 29(10):985–992. https://doi.org/10.1111/pan.13716CrossRefPubMed

155.

Scott A, Chua O, Mitchell W, Vlok R, Melhuish T, White L (2019) Apneic oxygenation for pediatric endotracheal Intubation: a narrative review. J Pediatr Intensive Care 8(3):117–121. https://doi.org/10.1055/s-0039-1678552CrossRefPubMedPubMedCentral

156.

Youngquist S, Gausche-Hill M, Burbulys D (2007) Alternative airway devices for use in children requiring prehospital airway management: update and case discussion. Pediatr Emerg Care 23(4):250–258. https://doi.org/10.1097/PEC.0b013e31803f7552 (quiz 259–61)CrossRefPubMed

157.

Else SDN, Kovatsis PG (2020) A narrative review of oxygenation during pediatric Intubation and airway procedures. Anesth Analg 130(4):831–840. https://doi.org/10.1213/ANE.0000000000004403CrossRefPubMed

158.

Long E, Barrett MJ, Peters C, Sabato S, Lockie F (2020) Emergency intubation of children outside of the operating room. Paediatr Anaesth 30(3):319–330. https://doi.org/10.1111/pan.13784CrossRefPubMed

159.

Fiadjoe J, Nishisaki A (2020) Normal and difficult airways in children: “What’s New”-Current evidence. Paediatr Anaesth 30(3):257–263. https://doi.org/10.1111/pan.13798CrossRefPubMedPubMedCentral

160.

Schreiber S, Ronfani L, Ghirardo S et al (2016) Nasal irrigation with saline solution significantly improves oxygen saturation in infants with bronchiolitis. Acta Paediatr 105(3):292–296. https://doi.org/10.1111/apa.13282CrossRefPubMed

161.

Sun J, Li XH, Zuo YX (2015) Comparison of Incidence of hypoxia during modified rapid sequence induction and an alternative technique: a prospective randomized controlled trial. Int J Clin Exp Med 8(9):16231–16237 (https://www.ncbi.nlm.nih.gov/pubmed/26629138)PubMedPubMedCentral

162.

Heschl S, Meadley B, Andrew E, Butt W, Bernard S, Smith K (2018) Efficacy of pre-hospital rapid sequence intubation in paediatric traumatic brain injury: a 9‑year observational study. Injury 49(5):916–920. https://doi.org/10.1016/j.injury.2018.02.013CrossRefPubMed

163.

Lawrason Hughes A, Murray N, Valdez TA, Kelly R, Kavanagh K (2014) Development of the Connecticut Airway Risk Evaluation (CARE) system to improve handoff communication in pediatric patients with tracheotomy. JAMA Otolaryngol Head Neck Surg 140(1):29–33. https://doi.org/10.1001/jamaoto.2013.5550CrossRefPubMed

164.

Matettore A, Ramnarayan P, Jones A et al (2019) Adverse tracheal Intubation-associated events in pediatric patients at nonspecialist centers: a multicenter prospective observational study. Pediatr Crit Care Med 20(6):518–526. https://doi.org/10.1097/PCC.0000000000001923CrossRefPubMed

165.

Hernandez MC, Antiel RM, Balakrishnan K, Zielinski MD, Klinkner DB (2018) Definitive airway management after prehospital supraglottic rescue airway in pediatric trauma. J Pediatr Surg 53(2):352–356. https://doi.org/10.1016/j.jpedsurg.2017.10.004CrossRefPubMed

166.

Simons T, Soderlund T, Handolin L (2017) Radiological evaluation of tube depth and complications of prehospital endotracheal intubation in pediatric trauma: a descriptive study. Eur J Trauma Emerg Surg 43(6):797–804. https://doi.org/10.1007/s00068-016-0758-2CrossRefPubMed

167.

Hansen M, Meckler G, Lambert W et al (2016) Patient safety events in out-of-hospital paediatric airway management: a medical record review by the CSI-EMS. BMJ Open 6(11):e12259. https://doi.org/10.1136/bmjopen-2016-012259CrossRefPubMedPubMedCentral

168.

Goto T, Gibo K, Hagiwara Y et al (2016) Factors associated with first-pass success in pediatric Intubation in the emergency department. West J Emerg Med 17(2):129–134. https://doi.org/10.5811/westjem.2016.1.28685CrossRefPubMedPubMedCentral

169.

Mortimer T, Burzynski J, Kesselman M, Vallance J, Hansen G (2016) Apneic oxygenation during rapid sequence Intubation in critically ill children. J Pediatr Intensive Care 5(1):28–31. https://doi.org/10.1055/s-0035-1568149CrossRefPubMed

170.

Fiadjoe JE, Nishisaki A, Jagannathan N et al (2016) Airway management complications in children with difficult tracheal intubation from the Pediatric Difficult Intubation (PeDI) registry: a prospective cohort analysis. Lancet Respir Med 4(1):37–48. https://doi.org/10.1016/S2213-2600(15)00508-1CrossRefPubMed

171.

Li S, Rehder KJ, Giuliano JS Jr. et al (2016) Development of a quality improvement bundle to reduce tracheal Intubation-associated events in pediatric ICUs. Am J Med Qual 31(1):47–55. https://doi.org/10.1177/1062860614547259CrossRefPubMed

172.

Johnson M, Miskovic A, Ray S et al (2019) The nasopharyngeal airway: estimation of the nares-to-mandible and nares-to-tragus distance in young children to assess current clinical practice. Resuscitation 140:50–54. https://doi.org/10.1016/j.resuscitation.2019.04.039CrossRefPubMed

173.

Garcia-Marcinkiewicz AG, Adams HD, Gurnaney H et al (2020) A retrospective analysis of neuromuscular blocking drug use and ventilation technique on complications in the pediatric difficult Intubation registry using propensity score matching. Anesth Analg 131(2):469–479. https://doi.org/10.1213/ANE.0000000000004393CrossRefPubMed

174.

Ramgopal S, Button SE, Owusu-Ansah S et al (2020) Success of pediatric Intubations performed by a critical care transport service. Prehosp Emerg Care 24(5):683–692. https://doi.org/10.1080/10903127.2019.1699212CrossRefPubMed

175.

Hansen M, Lambert W, Guise JM, Warden CR, Mann NC, Wang H (2015) Out-of-hospital pediatric airway management in the United States. Resuscitation 90:104–110. https://doi.org/10.1016/j.resuscitation.2015.02.018CrossRefPubMedPubMedCentral

176.

Conway JA, Kharayat P, Sanders RC Jr. et al (2020) Ketamine use for tracheal Intubation in critically ill children is associated with a lower occurrence of adverse hemodynamic events. Crit Care Med 48(6):e489–e497. https://doi.org/10.1097/CCM.0000000000004314CrossRefPubMed

177.

Galvez JA, Acquah S, Ahumada L et al (2019) Hypoxemia, bradycardia, and multiple laryngoscopy attempts during anesthetic induction in infants: a single-center, retrospective study. Anesthesiology 131(4):830–839. https://doi.org/10.1097/ALN.0000000000002847CrossRefPubMed

178.

Overmann KM, Boyd SD, Zhang Y, Kerrey BT (2019) Apneic oxygenation to prevent oxyhemoglobin desaturation during rapid sequence intubation in a pediatric emergency department. Am J Emerg Med 37(8):1416–1421. https://doi.org/10.1016/j.ajem.2018.10.030CrossRefPubMed

179.

Crulli B, Loron G, Nishisaki A, Harrington K, Essouri S, Emeriaud G (2016) Safety of paediatric tracheal intubation after non-invasive ventilation failure. Pediatr Pulmonol 51(2):165–172. https://doi.org/10.1002/ppul.23223CrossRefPubMed

180.

Neubrand TL, Alletag M, Woods J, Mendenhall M, Leonard J, Schmidt SK (2019) Breathing easier: decreasing tracheal Intubation-associated adverse events in the pediatric ED and urgent care. Pediatr Qual Saf 4(6):e230. https://doi.org/10.1097/pq9.0000000000000230CrossRefPubMedPubMedCentral

181.

Mokhateb-Rafii T, Bakar A, Gangadharan S et al (2019) Hemodynamic impact of oxygen desaturation during tracheal Intubation among critically ill children with cyanotic and Noncyanotic heart disease. Pediatr Crit Care Med 20(1):19–26. https://doi.org/10.1097/PCC.0000000000001766CrossRefPubMed

182.

Parker MM, Nuthall G, Brown C 3rd et al (2017) Relationship between adverse tracheal Intubation associated events and PICU outcomes. Pediatr Crit Care Med 18(4):310–318. https://doi.org/10.1097/PCC.0000000000001074CrossRefPubMedPubMedCentral

183.

van Sambeeck SJ, van Kuijk SMJ, Kramer BW, Vermeulen PM, Vos GD (2019) Endotracheal intubation skills of pediatricians versus anesthetists in neonates and children. Eur J Pediatr 178(8):1219–1227. https://doi.org/10.1007/s00431-019-03395-8CrossRefPubMedPubMedCentral

184.

Li S, Hsieh TC, Rehder KJ et al (2018) Frequency of desaturation and association with hemodynamic adverse events during tracheal Intubations in PICus. Pediatr Crit Care Med 19(1):e41–e50. https://doi.org/10.1097/PCC.0000000000001384CrossRefPubMed

185.

Daigle CH, Fiadjoe JE, Laverriere EK et al (2020) Difficult bag-mask ventilation in critically ill children is independently associated with adverse events. Crit Care Med 48(9):e744–e752. https://doi.org/10.1097/CCM.0000000000004425CrossRefPubMed

186.

Emami P, Czorlich P, Fritzsche FS et al (2019) Observed versus expected mortality in pediatric patients intubated in the field with Glasgow Coma Scale scores 〈 9. Eur J Trauma Emerg Surg 45(5):769–776. https://doi.org/10.1007/s00068-018-01065-2CrossRefPubMed

187.

Vukovic AA, Hanson HR, Murphy SL, Mercurio D, Sheedy CA, Arnold DH (2019) Apneic oxygenation reduces hypoxemia during endotracheal intubation in the pediatric emergency department. Am J Emerg Med 37(1):27–32. https://doi.org/10.1016/j.ajem.2018.04.039CrossRefPubMed

188.

Lee JH, Nuthall G, Ikeyama T et al (2019) Tracheal Intubation practice and safety across international PICus: a report from national emergency airway registry for children. Pediatr Crit Care Med 20(1):1–8. https://doi.org/10.1097/PCC.0000000000001782CrossRefPubMed

189.

Algie CM, Mahar RK, Tan HB, Wilson G, Mahar PD, Wasiak J (2015) Effectiveness and risks of cricoid pressure during rapid sequence induction for endotracheal intubation. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD011656.pub2CrossRefPubMedPubMedCentral

190.

Kojima T, Harwayne-Gidansky I, Shenoi AN et al (2018) Cricoid pressure during induction for tracheal Intubation in critically ill children: a report from national emergency airway registry for children. Pediatr Crit Care Med 19(6):528–537. https://doi.org/10.1097/PCC.0000000000001531CrossRefPubMed

191.

Kojima T, Laverriere EK, Owen EB et al (2018) Clinical impact of external laryngeal manipulation during laryngoscopy on tracheal Intubation success in critically ill children. Pediatr Crit Care Med 19(2):106–114. https://doi.org/10.1097/PCC.0000000000001373CrossRefPubMed

192.

Sun Y, Lu Y, Huang Y, Jiang H (2014) Pediatric video laryngoscope versus direct laryngoscope: a meta-analysis of randomized controlled trials. Paediatr Anaesth 24(10):1056–1065. https://doi.org/10.1111/pan.12458CrossRefPubMed

193.

Lingappan K, Arnold JL, Fernandes CJ, Pammi M (2018) Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD009975.pub3CrossRefPubMedPubMedCentral

194.

Abdelgadir IS, Phillips RS, Singh D, Moncreiff MP, Lumsden JL (2017) Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in children (excluding neonates). Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD011413.pub2CrossRefPubMedPubMedCentral

195.

Sola C, Saour AC, Macq C, Bringuier S, Raux O, Dadure C (2017) Children with challenging airways: what about GlideScope((R)) video-laryngoscopy? Anaesth Crit Care Pain Med 36(5):267–271. https://doi.org/10.1016/j.accpm.2016.10.005CrossRefPubMed

196.

Grunwell JR, Kamat PP, Miksa M et al (2017) Trend and outcomes of video laryngoscope use across PICus. Pediatr Crit Care Med 18(8):741–749. https://doi.org/10.1097/PCC.0000000000001175CrossRefPubMedPubMedCentral

197.

Park R, Peyton JM, Fiadjoe JE et al (2017) The efficacy of GlideScope(R) videolaryngoscopy compared with direct laryngoscopy in children who are difficult to intubate: an analysis from the paediatric difficult intubation registry. Br J Anaesth 119(5):984–992. https://doi.org/10.1093/bja/aex344CrossRefPubMed

198.

Kaji AH, Shover C, Lee J et al (2020) Video versus direct and augmented direct laryngoscopy in pediatric tracheal Intubations. Acad Emerg Med 27(5):394–402. https://doi.org/10.1111/acem.13869CrossRefPubMed

199.

Gupta A, Kamal G, Gupta A, Sehgal N, Bhatla S, Kumar R (2018) Comparative evaluation of CMAC and Truview picture capture device for endotracheal intubation in neonates and infants undergoing elective surgeries: a prospective randomized control trial. Paediatr Anaesth 28(12):1148–1153. https://doi.org/10.1111/pan.13524CrossRefPubMed

200.

Sinha R, Ray BR, Sharma A et al (2019) Comparison of the C‑MAC video laryngoscope size 2 macintosh blade with size 2 C‑MAC D‑blade for laryngoscopy and endotracheal intubation in children with simulated cervical spine injury: a prospective randomized crossover study. J Anaesthesiol Clin Pharmacol 35(4):509–514. https://doi.org/10.4103/joacp.JOACP_106_18CrossRefPubMedPubMedCentral

201.

Vadi MG, Roddy KJ, Ghazal EA, Um M, Neiheisel AJ, Applegate RL 2nd (2017) Comparison of the glidescope cobalt(R) and Storz DCI(R) video laryngoscopes in children younger than 2 years of age during manual in-line stabilization: a randomized trainee evaluation study. Pediatr Emerg Care 33(7):467–473. https://doi.org/10.1097/PEC.0000000000000607CrossRefPubMed

202.

Kim JE, Kwak HJ, Jung WS, Chang MY, Lee SY, Kim JY (2018) A comparison between McGrath MAC videolaryngoscopy and Macintosh laryngoscopy in children. Acta Anaesthesiol Scand 62(3):312–318. https://doi.org/10.1111/aas.13043CrossRefPubMed

203.

Jones P (2016) The therapeutic value of atropine for critical care intubation. Arch Dis Child 101(1):77–80. https://doi.org/10.1136/archdischild-2014-308137CrossRefPubMed

204.

Quintard H, l’Her E, Pottecher J et al (2019) Experts’ guidelines of intubation and extubation of the ICU patient of French Society of Anaesthesia and Intensive Care Medicine (SFAR) and French-speaking Intensive Care Society (SRLF) : In collaboration with the pediatric Association of French-speaking Anaesthetists and Intensivists (ADARPEF), French-speaking Group of Intensive Care and Paediatric emergencies (GFRUP) and Intensive Care physiotherapy society (SKR). Ann Intensive Care 9(1):13. https://doi.org/10.1186/s13613-019-0483-1CrossRefPubMedPubMedCentral

205.

Jones P, Peters MJ, Pinto da Costa N et al (2013) Atropine for critical care intubation in a cohort of 264 children and reduced mortality unrelated to effects on bradycardia. Plos One 8(2):e57478. https://doi.org/10.1371/journal.pone.0057478CrossRefPubMedPubMedCentral

206.

Jones P, Ovenden N, Dauger S, Peters MJ (2014) Estimating ‘lost heart beats’ rather than reductions in heart rate during the intubation of critically-ill children. Plos One 9(2):e86766. https://doi.org/10.1371/journal.pone.0086766CrossRefPubMedPubMedCentral

207.

Gill H, Thoresen M, Smit E et al (2014) Sedation management during therapeutic hypothermia for neonatal encephalopathy: atropine premedication for endotracheal intubation causes a prolonged increase in heart rate. Resuscitation 85(10):1394–1398. https://doi.org/10.1016/j.resuscitation.2014.07.002CrossRefPubMed

208.

Litman RS, Weissend EE, Shibata D, Westesson PL (2003) Developmental changes of laryngeal dimensions in unparalyzed, sedated children. Anesthesiology 98(1):41–45. https://doi.org/10.1097/00000542-200301000-00010CrossRefPubMed

209.

Kneyber MCJ, de Luca D, Calderini E et al (2017) Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC). Intensive Care Med 43(12):1764–1780. https://doi.org/10.1007/s00134-017-4920-zCrossRefPubMedPubMedCentral

210.

Tosif S, Duke T (2017) Evidence to support oxygen guidelines for children with emergency signs in developing countries: a systematic review and physiological and mechanistic analysis. J Trop Pediatr 63(5):402–413. https://doi.org/10.1093/tropej/fmw100CrossRefPubMed

211.

Rojas-Reyes MX, Granados Rugeles C, Charry-Anzola LP (2014) Oxygen therapy for lower respiratory tract infections in children between 3 months and 15 years of age. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD005975.pub3CrossRefPubMedPubMedCentral

212.

Grandville B, Petak F, Albu G, Bayat S, Pichon I, Habre W (2019) High inspired oxygen fraction impairs lung volume and ventilation heterogeneity in healthy children: a double-blind randomised controlled trial. Br J Anaesth 122(5):682–691. https://doi.org/10.1016/j.bja.2019.01.036CrossRefPubMed

213.

Patel B, Khine H, Shah A, Sung D, Medar S, Singer L (2019) Randomized clinical trial of high concentration versus titrated oxygen use in pediatric asthma. Pediatr Pulmonol 54(7):970–976. https://doi.org/10.1002/ppul.24329CrossRefPubMed

214.

Peters MJ, Jones GAL, Wiley D et al (2018) Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial. Intensive Care Med 44(8):1240–1248. https://doi.org/10.1007/s00134-018-5232-7CrossRefPubMed

215.

von der Weid L, Gehri M, Camara B, Thiongane A, Pascual A, Pauchard JY (2018) Clinical signs of hypoxaemia in children aged 2 months to 5 years with acute respiratory distress in Switzerland and Senegal. Paediatr Int Child Health 38(2):113–120. https://doi.org/10.1080/20469047.2017.1390828CrossRefPubMed

216.

Jones GAL, Ramnarayan P, Raman S et al (2017) Protocol for a randomised pilot multiple centre trial of conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU). BMJ Open 7(12):e19253. https://doi.org/10.1136/bmjopen-2017-019253CrossRefPubMedPubMedCentral

217.

Maitland K, Kiguli S, Opoka RO et al (2017) Children’s Oxygen Administration Strategies Trial (COAST): a randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia. Wellcome Open Res 2:100. https://doi.org/10.12688/wellcomeopenres.12747.2CrossRefPubMed

218.

Ramnarayan P, Lister P, Dominguez T et al (2018) FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): a multicentre pilot randomised controlled trial of high-flow nasal cannula therapy versus continuous positive airway pressure in paediatric critical care. Crit Care 22(1):144. https://doi.org/10.1186/s13054-018-2080-3CrossRefPubMedPubMedCentral

219.

Durand P, Guiddir T, Kyheng C et al (2020) A randomised trial of high-flow nasal cannula in infants with moderate bronchiolitis. Eur Respir J. https://doi.org/10.1183/13993003.01926-2019CrossRefPubMed

220.

Williams AM, Abramo TJ, Shah MV et al (2011) Safety and clinical findings of BiPAP utilization in children 20 kg or less for asthma exacerbations. Intensive Care Med 37(8):1338–1343. https://doi.org/10.1007/s00134-011-2238-9CrossRefPubMed

221.

Essouri S, Laurent M, Chevret L et al (2014) Improved clinical and economic outcomes in severe bronchiolitis with pre-emptive nCPAP ventilatory strategy. Intensive Care Med 40(1):84–91. https://doi.org/10.1007/s00134-013-3129-zCrossRefPubMed

222.

Abadesso C, Nunes P, Silvestre C, Matias E, Loureiro H, Almeida H (2012) Non-invasive ventilation in acute respiratory failure in children. Pediatr Rep 4(2):e16. https://doi.org/10.4081/pr.2012.e16CrossRefPubMedPubMedCentral

223.

Vitaliti G, Vitaliti MC, Finocchiaro MC et al (2017) Randomized comparison of helmet CPAP versus high-flow nasal cannula oxygen in pediatric respiratory distress. Respir Care 62(8):1036–1042. https://doi.org/10.4187/respcare.05384CrossRefPubMed

224.

Korang SK, Feinberg J, Wetterslev J, Jakobsen JC (2016) Non-invasive positive pressure ventilation for acute asthma in children. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD012067.pub2CrossRefPubMedPubMedCentral

225.

Combret Y, Prieur G, Roux PLE, Medrinal C (2017) Non-invasive ventilation improves respiratory distress in children with acute viral bronchiolitis: a systematic review. Minerva Anestesiol 83(6):624–637. https://doi.org/10.23736/S0375-9393.17.11708-6CrossRefPubMed

226.

Ballestero Y, De Pedro J, Portillo N, Martinez-Mugica O, Arana-Arri E, Benito J (2018) Pilot clinical trial of high-flow oxygen therapy in children with asthma in the emergency service. J Pediatr 194:204–210e3. https://doi.org/10.1016/j.jpeds.2017.10.075CrossRefPubMed

227.

Luo J, Duke T, Chisti MJ, Kepreotes E, Kalinowski V, Li J (2019) Efficacy of high-flow nasal cannula vs standard oxygen therapy or nasal continuous positive airway pressure in children with respiratory distress: a meta-analysis. J Pediatr 215:199–208e8. https://doi.org/10.1016/j.jpeds.2019.07.059CrossRefPubMed

228.

O’Brien S, Craig S, Babl FE et al (2019) ‘Rational use of high-flow therapy in infants with bronchiolitis. What do the latest trials tell us?’ A Paediatric Research in Emergency Departments International Collaborative perspective. J Paediatr Child Health 55(7):746–752. https://doi.org/10.1111/jpc.14496CrossRefPubMed

229.

Mikalsen IB, Davis P, Oymar K (2016) High flow nasal cannula in children: a literature review. Scand J Trauma Resusc Emerg Med 24:93. https://doi.org/10.1186/s13049-016-0278-4CrossRefPubMedPubMedCentral

230.

Vahlkvist S, Jurgensen L, la Cour A, Markoew S, Petersen TH, Kofoed PE (2020) High flow nasal cannula and continuous positive airway pressure therapy in treatment of viral bronchiolitis: a randomized clinical trial. Eur J Pediatr 179(3):513–518. https://doi.org/10.1007/s00431-019-03533-2CrossRefPubMed

231.

Gc VS, Franklin D, Whitty JA et al (2020) First-line oxygen therapy with high-flow in bronchiolitis is not cost saving for the health service. Arch Dis Child 105(10):975–980. https://doi.org/10.1136/archdischild-2019-318427CrossRefPubMed

232.

Figueroa L, Laffaye F (2017) Early use of continuous positive airway pressure in the treatment of moderate to severe acute lower respiratory tract infections among patients younger than 2 years old. Arch Argent Pediatr 115(3):277–281. https://doi.org/10.5546/aap.2017.eng.277CrossRefPubMed

233.

Chisti MJ, Salam MA, Smith JH et al (2015) Bubble continuous positive airway pressure for children with severe pneumonia and hypoxaemia in Bangladesh: an open, randomised controlled trial. Lancet 386(9998):1057–1065. https://doi.org/10.1016/S0140-6736(15)60249-5CrossRefPubMed

234.

Mandelzweig K, Leligdowicz A, Murthy S, Lalitha R, Fowler RA, Adhikari NKJ (2018) Non-invasive ventilation in children and adults in low- and low-middle income countries: A systematic review and meta-analysis. J Crit Care 47:310–319. https://doi.org/10.1016/j.jcrc.2018.01.007CrossRefPubMed

235.

Balfour-Lynn RE, Marsh G, Gorayi D, Elahi E, LaRovere J (2014) Non-invasive ventilation for children with acute respiratory failure in the developing world: literature review and an implementation example. Paediatr Respir Rev 15(2):181–187. https://doi.org/10.1016/j.prrv.2014.02.002CrossRefPubMed

236.

Richards M, Le Roux D, Cooke L, Argent A (2020) The influence of high flow nasal cannulae on the outcomes of severe respiratory disease in children admitted to a regional hospital in south africa. J Trop Pediatr 66(6):612–620. https://doi.org/10.1093/tropej/fmaa024CrossRefPubMed

237.

Yurtseven A, Turan C, Erseven E, Saz EU (2019) Comparison of heated humidi fi ed high-flow nasal cannula flow rates (1‑L.kg.min(−1) vs 2‑L.kg.min (−1) ) in the management of acute bronchiolitis. Pediatr Pulmonol 54(6):894–900. https://doi.org/10.1002/ppul.24318CrossRefPubMedPubMedCentral

238.

Kobayashi H, Takimoto T, Kitaoka H, Kijima T (2020) Aerosol spread with use of high-flow nasal cannulae: a computational fluid dynamics analysis. J Hosp Infect 106(1):204–205. https://doi.org/10.1016/j.jhin.2020.06.010CrossRefPubMedPubMedCentral

239.

Kochanek PM, Tasker RC, Bell MJ et al (2019) Management of pediatric severe traumatic brain injury: 2019 consensus and guidelines-based algorithm for first and second tier therapies. Pediatr Crit Care Med 20(3):269–279. https://doi.org/10.1097/PCC.0000000000001737CrossRefPubMed

240.

Kim GJ, Newth CJL, Khemani RG, Wong SL, Coates AL, Ross PA (2018) Does size matter when calculating the “correct” tidal volume for pediatric mechanical ventilation?: a hypothesis based on FVC. Chest 154(1):77–83. https://doi.org/10.1016/j.chest.2018.04.015CrossRefPubMed

241.

Bilharz JR, Wheeler CR, Walsh BK, Smallwood CD (2018) A comparative analysis of ideal body weight methods for pediatric mechanical ventilation. Respir Care 63(9):1079–1084. https://doi.org/10.4187/respcare.06021CrossRefPubMed

242.

Lee JH, Jung H, Jang YE et al (2019) Manual vs pressure-controlled facemask ventilation during the induction of general anesthesia in children: a prospective randomized controlled study. Paediatr Anaesth 29(4):331–337. https://doi.org/10.1111/pan.13594CrossRefPubMed

243.

Mumma JM, Durso FT, Dyes M, Dela CR, Fox VP, Hoey M (2018) Bag valve mask ventilation as a perceptual-cognitive skill. Hum Factors 60(2):212–221. https://doi.org/10.1177/0018720817744729CrossRefPubMed

244.

Kroll M, Das J, Siegler J (2019) Can altering grip technique and bag size optimize volume delivered with bag-valve-mask by emergency medical service providers? Prehosp Emerg Care 23(2):210–214. https://doi.org/10.1080/10903127.2018.1489020CrossRefPubMed

245.

Becker HJ, Langhan ML (2020) Can providers use clinical skills to assess the adequacy of ventilation in children during bag-valve mask ventilation? Pediatr Emerg Care 36(12):e695–e699. https://doi.org/10.1097/PEC.0000000000001314CrossRefPubMed

246.

Williams DC, Cheifetz IM (2019) Emerging approaches in pediatric mechanical ventilation. Expert Rev Respir Med 13(4):327–336. https://doi.org/10.1080/17476348.2019.1586536CrossRefPubMed

247.

Smallwood CD, Davis MD (2019) Year in review 2018: pediatric mechanical ventilation. Respir Care 64(7):855–863. https://doi.org/10.4187/respcare.07029CrossRefPubMed

248.

Conti G, Piastra M (2016) Mechanical ventilation for children. Curr Opin Crit Care 22(1):60–66. https://doi.org/10.1097/MCC.0000000000000271CrossRefPubMed

249.

Pediatric Acute Lung Injury Consensus Conference G (2015) Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med 16(5):428–439. https://doi.org/10.1097/PCC.0000000000000350CrossRef

250.

Pearsall MF, Feldman JM (2014) When does apparatus dead space matter for the pediatric patient? Anesth Analg 118(4):776–780. https://doi.org/10.1213/ANE.0000000000000148CrossRefPubMed

251.

Siegler J, Kroll M, Wojcik S, Moy HP (2017) Can EMS providers provide appropriate tidal volumes in a simulated adult-sized patient with a pediatric-sized bag-valve-mask? Prehosp Emerg Care 21(1):74–78. https://doi.org/10.1080/10903127.2016.1227003CrossRefPubMed

252.

van Vonderen JJ, Witlox RS, Kraaij S, te Pas AB (2014) Two-minute training for improving neonatal bag and mask ventilation. Plos One 9(10):e109049. https://doi.org/10.1371/journal.pone.0109049CrossRefPubMedPubMedCentral

253.

Khoury A, Hugonnot S, Cossus J et al (2014) From mouth-to-mouth to bag-valve-mask ventilation: evolution and characteristics of actual devices—a review of the literature. Biomed Res Int 2014:762053. https://doi.org/10.1155/2014/762053CrossRefPubMedPubMedCentral

254.

Balamuth F, Kittick M, McBride P et al (2019) Pragmatic pediatric trial of balanced versus normal saline fluid in sepsis: the PRoMPT BOLUS randomized controlled trial pilot feasibility study. Acad Emerg Med 26(12):1346–1356. https://doi.org/10.1111/acem.13815CrossRefPubMedPubMedCentral

255.

Parker MJ, Thabane L, Fox-Robichaud A et al (2016) A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial. Trials 17(1):556. https://doi.org/10.1186/s13063-016-1689-2CrossRefPubMedPubMedCentral

256.

Inwald DP, Butt W, Tasker RC. (2015) Fluid resuscitation of shock in children: what, whence and whither? Intensive Care Med 41(8):1457–1459. https://doi.org/10.1007/s00134-015-3905-zCrossRefPubMed

257.

Inwald DP, Canter R, Woolfall K et al (2019) Restricted fluid bolus volume in early septic shock: results of the Fluids in Shock pilot trial. Arch Dis Child 104(5):426–431. https://doi.org/10.1136/archdischild-2018-314924CrossRefPubMed

258.

Gaensbauer JT, Birkholz M, Smit MA, Garcia R, Todd JK (2018) Epidemiology and clinical relevance of toxic shock syndrome in US children. Pediatr Infect Dis J 37(12):1223–1226. https://doi.org/10.1097/INF.0000000000002002CrossRefPubMed

259.

Weiss SL, Fitzgerald JC, Pappachan J et al (2015) Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med 191(10):1147–1157. https://doi.org/10.1164/rccm.201412-2323OCCrossRefPubMedPubMedCentral

260.

Maitland K, Kiguli S, Opoka RO et al (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364(26):2483–2495. https://doi.org/10.1056/NEJMoa1101549CrossRefPubMed

261.

Tripathi A, Kabra SK, Sachdev HP, Lodha R (2015) Mortality and other outcomes in relation to first hour fluid resuscitation rate: a systematic review. Indian Pediatr 52(11):965–972. https://doi.org/10.1007/s13312-015-0754-3CrossRefPubMed

262.

Levin M, Cunnington AJ, Wilson C et al (2019) Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial. Lancet Respir Med 7(7):581–593. https://doi.org/10.1016/S2213-2600(19)30114-6CrossRefPubMedPubMedCentral

263.

Long E, Babl FE, Oakley E, Sheridan B, Duke T, Pediatric Research in Emergency Departments International C (2018) Cardiac index changes with fluid bolus therapy in children with sepsis-an observational study. Pediatr Crit Care Med 19(6):513–518. https://doi.org/10.1097/PCC.0000000000001534CrossRefPubMed

264.

Chang R, Holcomb JB (2016) Choice of fluid therapy in the initial management of sepsis, severe sepsis, and septic shock. Shock 46(1):17–26. https://doi.org/10.1097/SHK.0000000000000577CrossRefPubMedPubMedCentral

265.

Lewis SR, Pritchard MW, Evans DJ et al (2018) Colloids versus crystalloids for fluid resuscitation in critically ill people. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD000567.pub7CrossRefPubMedPubMedCentral

266.

Medeiros DN, Ferranti JF, Delgado AF, de Carvalho WB (2015) Colloids for the initial management of severe sepsis and septic shock in pediatric patients: a systematic review. Pediatr Emerg Care 31(11):e11–6. https://doi.org/10.1097/PEC.0000000000000601CrossRefPubMed

267.

Emrath ET, Fortenberry JD, Travers C, McCracken CE, Hebbar KB (2017) Resuscitation with balanced fluids is associated with improved survival in pediatric severe sepsis. Crit Care Med 45(7):1177–1183. https://doi.org/10.1097/CCM.0000000000002365CrossRefPubMed

268.

Weiss SL, Keele L, Balamuth F et al (2017) Crystalloid fluid choice and clinical outcomes in pediatric sepsis: a matched retrospective cohort study. J Pediatr 182:304–310e10. https://doi.org/10.1016/j.jpeds.2016.11.075CrossRefPubMedPubMedCentral

269.

Antequera Martin AM, Barea Mendoza JA, Muriel A et al (2019) Buffered solutions versus 0.9 % saline for resuscitation in critically ill adults and children. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD012247.pub2CrossRefPubMedPubMedCentral

270.

Ranjit S, Ramanathan G, Ramakrishnan B, Kissoon N (2018) Targeted interventions in critically ill children with severe dengue. Indian J Crit Care Med 22(3):154–161. https://doi.org/10.4103/ijccm.IJCCM_413_17CrossRefPubMedPubMedCentral

271.

Singh M, Sankar J, Kumar A, Kumar UV, Lodha R, Kabra SK (2019) Predictors of mortality in children admitted to the pediatric intensive care unit with acute gastroenteritis with severe dehydration. Indian J Pediatr 86(12):1142–1145. https://doi.org/10.1007/s12098-019-03094-0CrossRefPubMed

272.

Qadori M, Flem E, Bekkevold T et al (2018) Hypoglycaemia was common in acute gastroenteritis in a prospective hospital-based study, but electrolyte imbalances were not. Acta Paediatr 107(8):1455–1460. https://doi.org/10.1111/apa.14318CrossRefPubMed

273.

Vonasek BJ, Chiume M, Crouse HL et al (2020) Risk factors for mortality and management of children with complicated severe acute malnutrition at a tertiary referral hospital in Malawi. Paediatr Int Child Health 40(3):148–157. https://doi.org/10.1080/20469047.2020.1747003CrossRefPubMed

274.

Alam NH, Ashraf H, Ahmed T, Jahan N, Gyr N (2020) Randomised trial showed that rapid rehydration of severely malnourished children with dehydrating diarrhoea was as safe and effective as slow rehydration. Acta Paediatr 109(7):1473–1484. https://doi.org/10.1111/apa.15134CrossRefPubMed

275.

Houston KA, Gibb J, Olupot-Olupot P et al (2019) Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration. BMC Med 17(1):122. https://doi.org/10.1186/s12916-019-1356-zCrossRefPubMedPubMedCentral

276.

Iro MA, Sell T, Brown N, Maitland K (2018) Rapid intravenous rehydration of children with acute gastroenteritis and dehydration: a systematic review and meta-analysis. BMC Pediatr 18(1):44. https://doi.org/10.1186/s12887-018-1006-1CrossRefPubMedPubMedCentral

277.

Polites SF, Moody S, Williams RF et al (2020) Timing and volume of crystalloid and blood products in pediatric trauma: An Eastern Association for the Surgery of Trauma multicenter prospective observational study. J Trauma Acute Care Surg 89(1):36–42. https://doi.org/10.1097/TA.0000000000002702CrossRefPubMed

278.

Schauer SG, April MD, Becker TE, Cap AP, Borgman MA (2020) High crystalloid volumes negate benefit of hemostatic resuscitation in pediatric wartime trauma casualties. J Trauma Acute Care Surg 89(2S Suppl 2):S185–S191. https://doi.org/10.1097/TA.0000000000002590CrossRefPubMed

279.

Elkbuli A, Zajd S, Ehrhardt JD Jr., McKenney M, Boneva D (2020) Aggressive crystalloid resuscitation outcomes in low-severity pediatric trauma. J Surg Res 247:350–355. https://doi.org/10.1016/j.jss.2019.10.009CrossRefPubMed

280.

Polites SF, Nygaard RM, Reddy PN et al (2018) Multicenter study of crystalloid boluses and transfusion in pediatric trauma-When to go to blood? J Trauma Acute Care Surg 85(1):108–112. https://doi.org/10.1097/TA.0000000000001897CrossRefPubMed

281.

Magoteaux SR, Notrica DM, Langlais CS et al (2017) Hypotension and the need for transfusion in pediatric blunt spleen and liver injury: An ATOMAC+ prospective study. J Pediatr Surg 52(6):979–983. https://doi.org/10.1016/j.jpedsurg.2017.03.021CrossRefPubMed

282.

Nadler R, Mozer-Glassberg Y, Gaines B, Glassberg E, Chen J (2019) The Israel Defense Forces experience with freeze-dried plasma for the resuscitation of traumatized pediatric patients. J Trauma Acute Care Surg 87(6):1315–1320. https://doi.org/10.1097/TA.0000000000002477CrossRefPubMed

283.

Haltmeier T, Benjamin E, Gruen JP et al (2018) Decreased mortality in patients with isolated severe blunt traumatic brain injury receiving higher plasma to packed red blood cells transfusion ratios. Injury 49(1):62–66. https://doi.org/10.1016/j.injury.2017.07.035CrossRefPubMed

284.

Long B, April MD (2018) Does administration of hypertonic solutions improve mortality in hemorrhagic shock compared with isotonic solutions? Ann Emerg Med 71(4):529–531. https://doi.org/10.1016/j.annemergmed.2017.11.025CrossRefPubMed

285.

Phillips R, Acker SN, Shahi N et al (2020) The ABC‑D score improves the sensitivity in predicting need for massive transfusion in pediatric trauma patients. J Pediatr Surg 55(2):331–334. https://doi.org/10.1016/j.jpedsurg.2019.10.008CrossRefPubMed

286.

Figueiredo S, Taconet C, Harrois A et al (2018) How useful are hemoglobin concentration and its variations to predict significant hemorrhage in the early phase of trauma? A multicentric cohort study. Ann Intensive Care 8(1):76. https://doi.org/10.1186/s13613-018-0420-8CrossRefPubMedPubMedCentral

287.

Brinck T, Handolin L, Lefering R (2016) The effect of evolving fluid resuscitation on the outcome of severely injured patients: an 8‑year experience at a tertiary trauma center. Scand J Surg 105(2):109–116. https://doi.org/10.1177/1457496915586650CrossRefPubMed

288.

Wang CH, Hsieh WH, Chou HC et al (2014) Liberal versus restricted fluid resuscitation strategies in trauma patients: a systematic review and meta-analysis of randomized controlled trials and observational studies. Crit Care Med 42(4):954–961. https://doi.org/10.1097/CCM.0000000000000050CrossRefPubMed

289.

Albreiki M, Voegeli D (2018) Permissive hypotensive resuscitation in adult patients with traumatic haemorrhagic shock: a systematic review. Eur J Trauma Emerg Surg 44(2):191–202. https://doi.org/10.1007/s00068-017-0862-yCrossRefPubMed

290.

Tran A, Yates J, Lau A, Lampron J, Matar M (2018) Permissive hypotension versus conventional resuscitation strategies in adult trauma patients with hemorrhagic shock: A systematic review and meta-analysis of randomized controlled trials. J Trauma Acute Care Surg 84(5):802–808. https://doi.org/10.1097/TA.0000000000001816CrossRefPubMed

291.

Owattanapanich N, Chittawatanarat K, Benyakorn T, Sirikun J (2018) Risks and benefits of hypotensive resuscitation in patients with traumatic hemorrhagic shock: a meta-analysis. Scand J Trauma Resusc Emerg Med 26(1):107. https://doi.org/10.1186/s13049-018-0572-4CrossRefPubMedPubMedCentral

292.

Dittrich MHM, Hosni ND, de Carvalho WB (2020) Association between fluid creep and infection in burned children: a cohort study. Burns 46(5):1036–1042. https://doi.org/10.1016/j.burns.2020.02.003CrossRefPubMed

293.

Granfeldt A, Avis SR, Lind PC et al (2020) Intravenous vs. intraosseous administration of drugs during cardiac arrest: a systematic review. Resuscitation 149:150–157. https://doi.org/10.1016/j.resuscitation.2020.02.025CrossRefPubMed

294.

Jousi M, Laukkanen-Nevala P, Nurmi J (2019) Analysing blood from intraosseous access: a systematic review. Eur J Emerg Med 26(2):77–85. https://doi.org/10.1097/MEJ.0000000000000569CrossRefPubMed

295.

Ohchi F, Komasawa N, Mihara R, Minami T (2015) Comparison of mechanical and manual bone marrow puncture needle for intraosseous access; a randomized simulation trial. SpringerPlus 4:211. https://doi.org/10.1186/s40064-015-0982-yCrossRefPubMedPubMedCentral

296.

El-Nawawy AA, Omar OM, Khalil M (2018) Intraosseous versus intravenous access in pediatric septic shock patients admitted to alexandria university pediatric intensive care unit. J Trop Pediatr 64(2):132–140. https://doi.org/10.1093/tropej/fmx061CrossRefPubMed

297.

Maxien D, Wirth S, Peschel O et al (2019) Intraosseous needles in pediatric cadavers: rate of malposition. Resuscitation 145:1–7. https://doi.org/10.1016/j.resuscitation.2019.09.028CrossRefPubMed

298.

Al-Shibli A, Lim R, Poonai N, Istasy V, Lin K, Kilgar J (2020) Determination of the pretibial soft tissue thickness in children: are Intraosseous infusion needles long enough? Pediatr Emerg Care 36(1):39–42. https://doi.org/10.1097/PEC.0000000000002019CrossRefPubMed

299.

Mori T, Takei H, Sasaoka Y, Nomura O, Ihara T (2020) Semi-automatic intraosseous device (EZ-IO) in a paediatric emergency department. J Paediatr Child Health 56(9):1376–1381. https://doi.org/10.1111/jpc.14940CrossRefPubMed

300.

Harcke HT, Curtin RN, Harty MP et al (2020) Tibial Intraosseous insertion in pediatric emergency care: a review based upon postmortem computed tomography. Prehosp Emerg Care 24(5):665–671. https://doi.org/10.1080/10903127.2019.1698682CrossRefPubMed

301.

Szarpak L, Ladny JR, Dabrowski M et al (2020) Comparison of 4 pediatric intraosseous access devices: a randomized simulation study. Pediatr Emerg Care 36(10):e568–e572. https://doi.org/10.1097/PEC.0000000000001587CrossRefPubMed

302.

Hamed RK, Hartmans S, Gausche-Hill M (2013) Anesthesia through an intraosseous line using an 18-gauge intravenous needle for emergency pediatric surgery. J Clin Anesth 25(6):447–451. https://doi.org/10.1016/j.jclinane.2013.03.013CrossRefPubMed

303.

Kalechstein S, Permual A, Cameron BM et al (2012) Evaluation of a new pediatric intraosseous needle insertion device for low-resource settings. J Pediatr Surg 47(5):974–979. https://doi.org/10.1016/j.jpedsurg.2012.01.055CrossRefPubMed

304.

Isayama K, Nakatani T, Tsuda M, Hirakawa A (2012) Current status of establishing a venous line in CPA patients by Emergency Life-Saving Technicians in the prehospital setting in Japan and a proposal for intraosseous infusion. Int J Emerg Med 5(1):2. https://doi.org/10.1186/1865-1380-5-2CrossRefPubMedPubMedCentral

305.

Hansen M, Meckler G, Spiro D, Newgard C (2011) Intraosseous line use, complications, and outcomes among a population-based cohort of children presenting to California hospitals. Pediatr Emerg Care 27(10):928–932. https://doi.org/10.1097/PEC.0b013e3182307a2fCrossRefPubMed

306.

Sunde GA, Heradstveit BE, Vikenes BH, Heltne JK (2010) Emergency intraosseous access in a helicopter emergency medical service: a retrospective study. Scand J Trauma Resusc Emerg Med 18:52. https://doi.org/10.1186/1757-7241-18-52CrossRefPubMedPubMedCentral

307.

Bielski K, Szarpak L, Smereka J, Ladny JR, Leung S, Ruetzler K (2017) Comparison of four different intraosseous access devices during simulated pediatric resuscitation. A randomized crossover manikin trial. Eur J Pediatr 176(7):865–871. https://doi.org/10.1007/s00431-017-2922-zCrossRefPubMedPubMedCentral

308.

Pifko EL, Price A, Busch C et al (2018) Observational review of paediatric intraosseous needle placement in the paediatric emergency department. J Paediatr Child Health 54(5):546–550. https://doi.org/10.1111/jpc.13773CrossRefPubMed

309.

Johnson M, Inaba K, Byerly S et al (2016) Intraosseous infusion as a bridge to definitive access. Am Surg 82(10):876–880 (https://www.ncbi.nlm.nih.gov/pubmed/27779964)CrossRefPubMed

310.

Oksan D, Ayfer K (2013) Powered intraosseous device (EZ-IO) for critically ill patients. Indian Pediatr 50(7):689–691. https://doi.org/10.1007/s13312-013-0192-zCrossRefPubMed

311.

Reuter-Rice K, Patrick D, Kantor E, Nolin C, Foley J (2015) Characteristics of children who undergo intraosseous needle placement. Adv Emerg Nurs J 37(4):301–307. https://doi.org/10.1097/TME.0000000000000077CrossRefPubMed

312.

Lee SH, Frey M, Kerrey BT, Zhang Y, Byczkowski T, Geis GL (2020) A video-based, case-control study of factors associated with Intraosseous catheterization during pediatric resuscitation. Ann Emerg Med 75(6):755–761. https://doi.org/10.1016/j.annemergmed.2019.09.005CrossRefPubMed

313.

Abramson TM, Alreshaid L, Kang T, Mailhot T, Omer T (2018) FascIOtomy: ultrasound evaluation of an Intraosseous needle causing compartment syndrome. Clin Pract Cases Emerg Med 2(4):323–325. https://doi.org/10.5811/cpcem.2018.8.38854CrossRefPubMedPubMedCentral

314.

Tsung JW, Blaivas M, Stone MB (2009) Feasibility of point-of-care colour Doppler ultrasound confirmation of intraosseous needle placement during resuscitation. Resuscitation 80(6):665–668. https://doi.org/10.1016/j.resuscitation.2009.03.009CrossRefPubMed

315.

Oulego-Erroz I, Munoz-Lozon A, Alonso-Quintela P, Rodriguez-Nunez A (2016) Comparison of ultrasound guided brachiocephalic and internal jugular vein cannulation in critically ill children. J Crit Care 35:133–137. https://doi.org/10.1016/j.jcrc.2016.05.010CrossRefPubMed

316.

Gallagher RA, Levy J, Vieira RL, Monuteaux MC, Stack AM (2014) Ultrasound assistance for central venous catheter placement in a pediatric emergency department improves placement success rates. Acad Emerg Med 21(9):981–986. https://doi.org/10.1111/acem.12460CrossRefPubMed

317.

Stinson HR, Viteri S, Koetter P et al (2019) Early experience with a novel strategy for assessment of sepsis risk: the shock huddle. Pediatr Qual Saf 4(4):e197. https://doi.org/10.1097/pq9.0000000000000197CrossRefPubMedPubMedCentral

318.

Wulff A, Montag S, Marschollek M, Jack T (2019) Clinical decision-support systems for detection of systemic inflammatory response syndrome, sepsis, and septic shock in critically ill patients: a systematic review. Methods Inf Med 58(S 02):e43–e57. https://doi.org/10.1055/s-0039-1695717CrossRefPubMed

319.

Pepper DJ, Natanson C, Eichacker PQ (2018) Evidence underpinning the centers for medicare & medicaid services’ severe sepsis and septic shock management bundle (SEP-1). Ann Intern Med 168(8):610–612. https://doi.org/10.7326/L18-0140CrossRefPubMed

320.

Barboza CL, Valete CO, da Silva AR (2020) Bundle adherence of intravenous antibiotic fluid resuscitation and vasopressor in children with severe sepsis or septic shock. Indian J Crit Care Med 24(2):128–132. https://doi.org/10.5005/jp-journals-10071-23336CrossRefPubMedPubMedCentral

321.

Balamuth F, Weiss SL, Fitzgerald JC et al (2016) Protocolized treatment is associated with decreased organ dysfunction in pediatric severe sepsis. Pediatr Crit Care Med 17(9):817–822. https://doi.org/10.1097/PCC.0000000000000858CrossRefPubMedPubMedCentral

322.

Workman JK, Ames SG, Reeder RW et al (2016) Treatment of pediatric septic shock with the surviving sepsis campaign guidelines and PICU patient outcomes. Pediatr Crit Care Med 17(10):e451–e458. https://doi.org/10.1097/PCC.0000000000000906CrossRefPubMed

323.

Lane RD, Funai T, Reeder R, Larsen GY (2016) High reliability pediatric septic shock quality improvement initiative and decreasing mortality. Pediatrics. https://doi.org/10.1542/peds.2015-4153CrossRefPubMed

324.

Hebert A, Boucher MP, Guimont C, Weiss M (2017) Effect of measuring vital signs on recognition and treatment of septic children. Paediatr Child Health 22(1):13–16. https://doi.org/10.1093/pch/pxw003CrossRefPubMedPubMedCentral

325.

Paul R, Melendez E, Wathen B et al (2018) A quality improvement collaborative for pediatric sepsis: lessons learned. Pediatr Qual Saf 3(1):e51. https://doi.org/10.1097/pq9.0000000000000051CrossRefPubMed

326.

Evans IVR, Phillips GS, Alpern ER et al (2018) Association between the New York sepsis care mandate and in-hospital mortality for pediatric sepsis. JAMA 320(4):358–367. https://doi.org/10.1001/jama.2018.9071CrossRefPubMedPubMedCentral

327.

Samransamruajkit R, Limprayoon K, Lertbunrian R et al (2018) The utilization of the surviving sepsis campaign care bundles in the treatment of pediatric patients with severe sepsis or septic shock in a resource-limited environment: a prospective multicenter trial. Indian J Crit Care Med 22(12):846–851. https://doi.org/10.4103/ijccm.IJCCM_367_18CrossRefPubMedPubMedCentral

328.

Kortz TB, Axelrod DM, Chisti MJ, Kache S (2017) Clinical outcomes and mortality before and after implementation of a pediatric sepsis protocol in a limited resource setting: A retrospective cohort study in Bangladesh. Plos One 12(7):e181160. https://doi.org/10.1371/journal.pone.0181160CrossRefPubMedPubMedCentral

329.

Lane RD, Olson J, Reeder R et al (2020) Antibiotic timing in pediatric septic shock. Hosp Pediatr 10(4):311–317. https://doi.org/10.1542/hpeds.2019-0250CrossRefPubMed

330.

Kyo M, Ohshimo S, Kosaka T, Fujita N, Shime N (2019) Impact of inappropriate empiric antimicrobial therapy on mortality in pediatric patients with bloodstream infection: a retrospective observational study. J Chemother 31(7–8):388–393. https://doi.org/10.1080/1120009X.2019.1623362CrossRefPubMed

331.

van Paridon BM, Guerra GG, Sheppard C, Joffe AR, Sepsis AN (2015) Timing of antibiotics, volume, and vasoactive infusions in children with sepsis admitted to intensive care. Crit Care 19:293. https://doi.org/10.1186/s13054-015-1010-xCrossRefPubMedPubMedCentral

332.

Carapetis JR, Jacoby P, Carville K, Ang SJ, Curtis N, Andrews R (2014) Effectiveness of clindamycin and intravenous immunoglobulin, and risk of disease in contacts, in invasive group a streptococcal infections. Clin Infect Dis 59(3):358–365. https://doi.org/10.1093/cid/ciu304CrossRefPubMed

333.

Weiss SL, Fitzgerald JC, Balamuth F et al (2014) Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med 42(11):2409–2417. https://doi.org/10.1097/CCM.0000000000000509CrossRefPubMedPubMedCentral

334.

Fusco NM, Parbuoni KA, Morgan JA (2015) Time to first antimicrobial administration after onset of sepsis in critically ill children. J Pediatr Pharmacol Ther 20(1):37–44. https://doi.org/10.5863/1551-6776-20.1.37CrossRefPubMedPubMedCentral

335.

Han M, Fitzgerald JC, Balamuth F et al (2017) Association of delayed antimicrobial therapy with one-year mortality in pediatric sepsis. Shock 48(1):29–35. https://doi.org/10.1097/SHK.0000000000000833CrossRefPubMedPubMedCentral

336.

Li Q, Cheng J, Wu Y et al (2019) Effects of delayed antibiotic therapy on outcomes in children with streptococcus pneumoniae sepsis. Antimicrob Agents Chemother. https://doi.org/10.1128/AAC.00623-19CrossRefPubMedPubMedCentral

337.

Tran P, Dowell E, Hamilton S et al (2020) Two blood cultures with age-appropriate volume enhance suspected sepsis decision-making. Open Forum Infect Dis 7(2):ofaa28. https://doi.org/10.1093/ofid/ofaa028CrossRefPubMedPubMedCentral

338.

Ventura AM, Shieh HH, Bousso A et al (2015) Double-blind prospective randomized controlled trial of dopamine versus epinephrine as first-line vasoactive drugs in pediatric septic shock. Crit Care Med 43(11):2292–2302. https://doi.org/10.1097/CCM.0000000000001260CrossRefPubMed

339.

Ramaswamy KN, Singhi S, Jayashree M, Bansal A, Nallasamy K (2016) Double-blind randomized clinical trial comparing dopamine and epinephrine in pediatric fluid-refractory hypotensive septic shock. Pediatr Crit Care Med 17(11):e502–e512. https://doi.org/10.1097/PCC.0000000000000954CrossRefPubMed

340.

Wen L, Xu L (2020) The efficacy of dopamine versus epinephrine for pediatric or neonatal septic shock: a meta-analysis of randomized controlled studies. Ital J Pediatr 46(1):6. https://doi.org/10.1186/s13052-019-0768-xCrossRefPubMedPubMedCentral

341.

Masarwa R, Paret G, Perlman A, Reif S, Raccah BH, Matok I (2017) Role of vasopressin and terlipressin in refractory shock compared to conventional therapy in the neonatal and pediatric population: a systematic review, meta-analysis, and trial sequential analysis. Crit Care 21(1):1. https://doi.org/10.1186/s13054-016-1589-6CrossRefPubMedPubMedCentral

342.

Lampin ME, Rousseaux J, Botte A, Sadik A, Cremer R, Leclerc F (2012) Noradrenaline use for septic shock in children: doses, routes of administration and complications. Acta Paediatr 101(9):e426–e430. https://doi.org/10.1111/j.1651-2227.2012.02725.xCrossRefPubMed

343.

Michel J, Hofbeck M, Spiller G, Renk H, Kumpf M, Neunhoeffer F (2017) Safety and efficacy of terlipressin in pediatric distributive shock: a retrospective analysis in 20 children. Paediatr Drugs 19(1):35–41. https://doi.org/10.1007/s40272-016-0199-8CrossRefPubMed

344.

Patregnani JT, Sochet AA, Klugman D (2017) Short-term peripheral vasoactive infusions in pediatrics: where is the Harm? Pediatr Crit Care Med 18(8):e378–e381. https://doi.org/10.1097/PCC.0000000000001230CrossRefPubMed

345.

Morin L, Kneyber M, Jansen NJG et al (2019) Translational gap in pediatric septic shock management: an ESPNIC perspective. Ann Intensive Care 9(1):73. https://doi.org/10.1186/s13613-019-0545-4CrossRefPubMedPubMedCentral

346.

Ranjit S, Natraj R, Kandath SK, Kissoon N, Ramakrishnan B, Marik PE (2016) Early norepinephrine decreases fluid and ventilatory requirements in pediatric vasodilatory septic shock. Indian J Crit Care Med 20(10):561–569. https://doi.org/10.4103/0972-5229.192036CrossRefPubMedPubMedCentral

347.

Ferguson LP, Thiru Y, Staffa SJ, Guillen Ortega M (2020) Reducing cardiac arrests in the PICU: initiative to improve time to administration of prearrest bolus epinephrine in patients with cardiac disease. Crit Care Med 48(7):e542–e549. https://doi.org/10.1097/CCM.0000000000004349CrossRefPubMed

348.

Gamper G, Havel C, Arrich J et al (2016) Vasopressors for hypotensive shock. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD003709.pub4CrossRefPubMedPubMedCentral

349.

Misir A, Mehrotra S (2018) Fluid and medication considerations in the traumatized patient. Curr Pediatr Rev 14(1):9–27. https://doi.org/10.2174/1573396313666170815101504CrossRefPubMed

350.

Health RCoPaC Major trauma and the use of tranexamic acid in children Evidence statement Royal College of Paediatrics and Child Health. November 2012. https://www.rcem.ac.uk/docs/ExternalGuidance/

351.

Patel J, Prajapati M, Patel H, Gandhi H, Deodhar S, Pandya H (2017) Topical and low-dose intravenous tranexamic acid in cyanotic cardiac surgery. Asian Cardiovasc Thorac Ann 25(2):118–122. https://doi.org/10.1177/0218492316688416CrossRefPubMed

352.

O’Neil ER, Schmees LR, Resendiz K, Justino H, Anders MM (2020) Inhaled tranexamic acid as a novel treatment for pulmonary hemorrhage in critically ill pediatric patients: an observational study. Crit Care 2(1):e75. https://doi.org/10.1097/CCE.0000000000000075CrossRef

353.

Maeda T, Michihata N, Sasabuchi Y et al (2018) Safety of tranexamic acid during pediatric trauma: a nationwide database study. Pediatr Crit Care Med 19(12):e637–e642. https://doi.org/10.1097/PCC.0000000000001724CrossRefPubMed

354.

Eckert MJ, Wertin TM, Tyner SD, Nelson DW, Izenberg S, Martin MJ (2014) Tranexamic acid administration to pediatric trauma patients in a combat setting: the pediatric trauma and tranexamic acid study (PED-TRAX). J Trauma Acute Care Surg 77(6):852–858. https://doi.org/10.1097/TA.0000000000000443 (discussion 858)CrossRefPubMed

355.

Lin CY, Shuhaiber JH, Loyola H et al (2015) The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery. Plos One 10(5):e126514. https://doi.org/10.1371/journal.pone.0126514CrossRefPubMedPubMedCentral

356.

Zhang Y, Wang R, Wang YH et al (2019) Effects of tranexamic acid on the blood conservation and the long-term prognosis in pediatric patients undergoing repair for tetralogy of fallot. Zhonghua Yi Xue Za Zhi 99(45):3564–3567. https://doi.org/10.3760/cma.j.issn.0376-2491.2019.45.007CrossRefPubMed

357.

Crash-trial collaborators, Shakur H, Roberts I et al (2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376(9734):23–32. https://doi.org/10.1016/S0140-6736(10)60835-5CrossRef

358.

collaborators C‑t. (2019) Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Lancet 394(10210):1713–1723. https://doi.org/10.1016/S0140-6736(19)32233-0CrossRef

359.

Menon K, McNally D, Choong K, Sampson M (2013) A systematic review and meta-analysis on the effect of steroids in pediatric shock. Pediatr Crit Care Med 14(5):474–480. https://doi.org/10.1097/PCC.0b013e31828a8125CrossRefPubMed

360.

El-Nawawy A, Khater D, Omar H, Wali Y (2017) Evaluation of early corticosteroid therapy in management of pediatric septic shock in pediatric intensive care patients: a randomized clinical study. Pediatr Infect Dis J 36(2):155–159. https://doi.org/10.1097/INF.0000000000001380CrossRefPubMed

361.

Wong HR, Cvijanovich NZ, Anas N et al (2018) Endotype transitions during the acute phase of pediatric septic shock reflect changing risk and treatment response. Crit Care Med 46(3):e242–e249. https://doi.org/10.1097/CCM.0000000000002932CrossRefPubMedPubMedCentral

362.

Wong HR, Atkinson SJ, Cvijanovich NZ et al (2016) Combining prognostic and predictive enrichment strategies to identify children with septic shock responsive to corticosteroids. Crit Care Med 44(10):e1000–e1003. https://doi.org/10.1097/CCM.0000000000001833CrossRefPubMedPubMedCentral

363.

Nichols B, Kubis S, Hewlett J, Yehya N, Srinivasan V (2017) Hydrocortisone therapy in catecholamine-resistant pediatric septic shock: a pragmatic analysis of clinician practice and association with outcomes. Pediatr Crit Care Med 18(9):e406–e414. https://doi.org/10.1097/PCC.0000000000001237CrossRefPubMedPubMedCentral

364.

Menon K, McNally JD, Choong K et al (2015) A cohort study of pediatric shock: frequency of corticosteriod use and association with clinical outcomes. Shock 44(5):402–409. https://doi.org/10.1097/SHK.0000000000000355CrossRefPubMed

365.

Atkinson SJ, Cvijanovich NZ, Thomas NJ et al (2014) Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis. Plos One 9(11):e112702. https://doi.org/10.1371/journal.pone.0112702CrossRefPubMedPubMedCentral

366.

Cooney L, Hawcutt D, Sinha I (2016) The evidence for intravenous theophylline levels between 10–20 mg/L in children suffering an acute exacerbation of asthma: a systematic review. Plos One 11(4):e153877. https://doi.org/10.1371/journal.pone.0153877CrossRefPubMedPubMedCentral

367.

Cooney L, Sinha I, Hawcutt D (2016) Aminophylline dosage in Asthma exacerbations in children: a systematic review. Plos One 11(8):e159965. https://doi.org/10.1371/journal.pone.0159965CrossRefPubMedPubMedCentral

368.

Mathew JL (2017) Systematic review on efficacy of Magnesium (intravenous or nebulized) for acute asthma episodes in children: evidence-based medicine viewpoint. Indian Pediatr 54(2):133–136. https://doi.org/10.1007/s13312-017-1016-3CrossRefPubMed

369.

Vezina K, Chauhan BF, Ducharme FM (2014) Inhaled anticholinergics and short-acting beta(2)-agonists versus short-acting beta2-agonists alone for children with acute asthma in hospital. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD010283.pub2CrossRefPubMed

370.

Knightly R, Milan SJ, Hughes R et al (2017) Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD003898.pub6CrossRefPubMedPubMedCentral

371.

Keeney GE, Gray MP, Morrison AK et al (2014) Dexamethasone for acute asthma exacerbations in children: a meta-analysis. Pediatrics 133(3):493–499. https://doi.org/10.1542/peds.2013-2273CrossRefPubMedPubMedCentral

372.

Pde SS, Barreto SS (2015) Noninvasive ventilation in status asthmaticus in children: levels of evidence. Rev Bras Ter Intensiva 27(4):390–396. https://doi.org/10.5935/0103-507X.20150065CrossRef

373.

Liu X, Yu T, Rower JE, Campbell SC, Sherwin CM, Johnson MD (2016) Optimizing the use of intravenous magnesium sulfate for acute asthma treatment in children. Pediatr Pulmonol 51(12):1414–1421. https://doi.org/10.1002/ppul.23482CrossRefPubMed

374.

Hon KLE, Leung AKC (2017) Medications and recent patents for status Asthmaticus in children. Recent Pat Inflamm Allergy Drug Discov 11(1):12–21. https://doi.org/10.2174/1872213X11666170130143524CrossRefPubMed

375.

Pardue Jones B, Fleming GM, Otillio JK, Asokan I, Arnold DH (2016) Pediatric acute asthma exacerbations: evaluation and management from emergency department to intensive care unit. J Asthma 53(6):607–617. https://doi.org/10.3109/02770903.2015.1067323CrossRefPubMed

376.

Tiwari A, Guglani V, Jat KR (2016) Ketamine versus aminophylline for acute asthma in children: a randomized, controlled trial. Ann Thorac Med 11(4):283–288. https://doi.org/10.4103/1817-1737.191874CrossRefPubMedPubMedCentral

377.

Cronin JJ, McCoy S, Kennedy U et al (2016) A randomized trial of single-dose oral dexamethasone versus multidose prednisolone for acute exacerbations of asthma in children who attend the emergency department. Ann Emerg Med 67(5):593–601e3. https://doi.org/10.1016/j.annemergmed.2015.08.001CrossRefPubMed

378.

Paniagua N, Lopez R, Munoz N et al (2017) Randomized trial of dexamethasone versus prednisone for children with acute asthma exacerbations. J Pediatr 191(e1):190–196e1. https://doi.org/10.1016/j.jpeds.2017.08.030CrossRefPubMed

379.

Alangari AA, Malhis N, Mubasher M et al (2014) Budesonide nebulization added to systemic prednisolone in the treatment of acute asthma in children: a double-blind, randomized, controlled trial. Chest 145(4):772–778. https://doi.org/10.1378/chest.13-2298CrossRefPubMed

380.

Muchao FP, Souza JM, Torres HC et al (2016) Albuterol via metered-dose inhaler in children: lower doses are effective, and higher doses are safe. Pediatr Pulmonol 51(11):1122–1130. https://doi.org/10.1002/ppul.23469CrossRefPubMed

381.

Arulparithi CS, Babu TA, Ravichandran C et al (2015) Efficacy of nebulised budesonide versus oral prednisolone in acute severe asthma. Indian J Pediatr 82(4):328–332. https://doi.org/10.1007/s12098-014-1498-0CrossRefPubMed

382.

Iramain R, Castro-Rodriguez JA, Jara A et al (2019) Salbutamol and ipratropium by inhaler is superior to nebulizer in children with severe acute asthma exacerbation: randomized clinical trial. Pediatr Pulmonol 54(4):372–377. https://doi.org/10.1002/ppul.24244CrossRefPubMed

383.

Cundiff KM, Gerard JM, Flood RG (2018) Critical care interventions for asthmatic patients admitted from the emergency department to the pediatric intensive care unit. Pediatr Emerg Care 34(6):385–389. https://doi.org/10.1097/PEC.0000000000001163CrossRefPubMed

384.

Hudgins JD, Neuman MI, Monuteaux MC, Porter J, Nelson KA (2019) Provision of guideline-based pediatric asthma care in US emergency departments. Pediatr Emerg Care. https://doi.org/10.1097/PEC.0000000000001706CrossRef

385.

Golden C, Xu M, Estrada CM, Arnold DH (2015) Clinical outcomes after bilevel positive airway pressure treatment for acute asthma exacerbations. JAMA Pediatr 169(2):186–188. https://doi.org/10.1001/jamapediatrics.2014.2767CrossRefPubMed

386.

Rehder KJ (2017) Adjunct therapies for refractory status Asthmaticus in children. Respir Care 62(6):849–865. https://doi.org/10.4187/respcare.05174CrossRefPubMed

387.

Wisecup S, Eades S, Hashmi SS, Samuels C, Mosquera RA (2015) Diastolic hypotension in pediatric patients with asthma receiving continuous albuterol. J Asthma 52(7):693–698. https://doi.org/10.3109/02770903.2014.1002566CrossRefPubMed

388.

Male I, Richter H, Seddon P (2000) Children’s perception of breathlessness in acute asthma. Arch Dis Child 83(4):325–329. https://doi.org/10.1136/adc.83.4.325CrossRefPubMedPubMedCentral

389.

Cates CJ, Welsh EJ, Rowe BH (2013) Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD000052.pub3CrossRefPubMedPubMedCentral

390.

Watts K, Chavasse RJ (2012) Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD006100.pub2CrossRefPubMedPubMedCentral

391.

Griffiths B, Ducharme FM (2013) Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD000060.pub2CrossRefPubMedPubMedCentral

392.

Edmonds ML, Milan SJ, Camargo CA Jr., Pollack CV, Rowe BH (2012) Early use of inhaled corticosteroids in the emergency department treatment of acute asthma. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD002308.pub2CrossRefPubMedPubMedCentral

393.

Jat KR, Chawla D (2012) Ketamine for management of acute exacerbations of asthma in children. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD009293.pub2CrossRefPubMedPubMedCentral

394.

Le Conte P, Terzi N, Mortamet G et al (2019) Management of severe asthma exacerbation: guidelines from the Societe Francaise de Medecine d’Urgence, the Societe de Reanimation de Langue Francaise and the French Group for Pediatric Intensive Care and Emergencies. Ann Intensive Care 9(1):115. https://doi.org/10.1186/s13613-019-0584-xCrossRefPubMedPubMedCentral

395.

Wei J, Lu Y, Han F, Zhang J, Liu L, Chen Q (2019) Oral dexamethasone vs. oral prednisone for children with acute asthma exacerbations: a systematic review and meta-analysis. Front Pediatr 7:503. https://doi.org/10.3389/fped.2019.00503CrossRefPubMedPubMedCentral

396.

Murphy KR, Hong JG, Wandalsen G et al (2020) Nebulized inhaled corticosteroids in asthma treatment in children 5 years or younger: a systematic review and global expert analysis. J Allergy Clin Immunol Pract 8(6):1815–1827. https://doi.org/10.1016/j.jaip.2020.01.042CrossRefPubMed

397.

Liedtke AG, Lava SAG, Milani GP et al (2019) Selective ss2-Adrenoceptor agonists and relevant hyperlactatemia: systematic review and meta-analysis. J Clin Med. https://doi.org/10.3390/jcm9010071CrossRefPubMedPubMedCentral

398.

Kwon JW (2020) High-flow nasal cannula oxygen therapy in children: a clinical review. Clin Exp Pediatr 63(1):3–7. https://doi.org/10.3345/kjp.2019.00626CrossRefPubMed

399.

Katsunuma T, Fujisawa T, Maekawa T et al (2019) Low-dose l‑isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial. Allergol Int 68(3):335–341. https://doi.org/10.1016/j.alit.2019.02.001CrossRefPubMed

400.

Graff DM, Stevenson MD, Berkenbosch JW (2019) Safety of prolonged magnesium sulfate infusions during treatment for severe pediatric status asthmaticus. Pediatr Pulmonol 54(12):1941–1947. https://doi.org/10.1002/ppul.24499CrossRefPubMed

401.

Messer AF, Sampayo EM, Mothner B et al (2019) Continuous albuterol in pediatric acute care: study demonstrates safety outside the intensive care unit. Pediatr Qual Saf 4(6):e225. https://doi.org/10.1097/pq9.0000000000000225CrossRefPubMedPubMedCentral

402.

Boeschoten S, de Hoog M, Kneyber M, Merkus P, Boehmer A, Buysse C (2020) Current practices in children with severe acute asthma across European PICUs: an ESPNIC survey. Eur J Pediatr 179(3):455–461. https://doi.org/10.1007/s00431-019-03502-9CrossRefPubMed

403.

Kapuscinski CA, Stauber SD, Hutchinson DJ (2020) Escalation in therapy based on intravenous Magnesium sulfate dosing in pediatric patients with asthma exacerbations. J Pediatr Pharmacol Ther 25(4):314–319. https://doi.org/10.5863/1551-6776-25.4.314CrossRefPubMedPubMedCentral

404.

Lott C, Alfonzo A, Barelli A, González-Salvado V, Hinkelbein J, Nolan JP, Paal P, Perkins GD, Thies K‑C, Yeung J, Zideman DA, Soar J (2021) European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances. Resuscitation 161:152–219. https://doi.org/10.1016/j.resuscitation.2021.02.011CrossRefPubMed

405.

Muraro A, Roberts G, Worm M et al (2014) Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology. Allergy 69(8):1026–1045. https://doi.org/10.1111/all.12437CrossRefPubMed

406.

Simons FE, Ardusso LR, Bilo MB et al (2014) International consensus on (ICON) anaphylaxis. World Allergy Organ J 7(1):9. https://doi.org/10.1186/1939-4551-7-9CrossRefPubMedPubMedCentral

407.

Simons FE, Ebisawa M, Sanchez-Borges M et al (2015) 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines. World Allergy Organ J 8(1):32. https://doi.org/10.1186/s40413-015-0080-1CrossRefPubMedPubMedCentral

408.

Shaker MS, Wallace DV, Golden DBK et al (2020) Anaphylaxis‑a 2020 practice parameter update, systematic review, and grading of recommendations, assessment, development and evaluation (GRADE) analysis. J Allergy Clin Immunol 145(4):1082–1123. https://doi.org/10.1016/j.jaci.2020.01.017CrossRefPubMed

409.

Sicherer SH, Simons FER, Section On A, Immunology (2017) Epinephrine for first-aid management of anaphylaxis. Pediatrics. https://doi.org/10.1542/peds.2016-4006CrossRefPubMed

410.

Halbrich M, Mack DP, Carr S, Watson W, Kim H (2015) CSACI position statement: epinephrine auto-injectors and children 〈 15 kg. Allergy Asthma Clin Immunol 11(1):20. https://doi.org/10.1186/s13223-015-0086-9CrossRefPubMedPubMedCentral

411.

Lieberman P, Nicklas RA, Randolph C et al (2015) Anaphylaxis—a practice parameter update 2015. Ann Allergy Asthma Immunol 115(5):341–384. https://doi.org/10.1016/j.anai.2015.07.019CrossRefPubMed

412.

Campbell RL, Li JT, Nicklas RA, Sadosty AT, Members of the Joint Task F, Practice Parameter W (2014) Emergency department diagnosis and treatment of anaphylaxis: a practice parameter. Ann Allergy Asthma Immunol 113(6):599–608. https://doi.org/10.1016/j.anai.2014.10.007CrossRefPubMed

413.

Atanaskovic-Markovic M, Gomes E, Cernadas JR et al (2019) Diagnosis and management of drug-induced anaphylaxis in children: An EAACI position paper. Pediatr Allergy Immunol 30(3):269–276. https://doi.org/10.1111/pai.13034CrossRefPubMed

414.

Turner PJ, Worm M, Ansotegui IJ et al (2019) Time to revisit the definition and clinical criteria for anaphylaxis? World Allergy Organ J 12(10):100066. https://doi.org/10.1016/j.waojou.2019.100066CrossRefPubMedPubMedCentral

415.

Resuscitation AaNZCo. First Aid Management of Anaphylaxis. Australian Resuscitation Council. (https://resus.org.au/editorial-changes-guidelines/).

416.

Liyanage CK, Galappatthy P, Seneviratne SL (2017) Corticosteroids in management of anaphylaxis; a systematic review of evidence. Eur Ann Allergy Clin Immunol 49(5):196–207. https://doi.org/10.23822/EurAnnACI.1764-1489.15CrossRefPubMed

417.

Pourmand A, Robinson C, Syed W, Mazer-Amirshahi M (2018) Biphasic anaphylaxis: a review of the literature and implications for emergency management. Am J Emerg Med 36(8):1480–1485. https://doi.org/10.1016/j.ajem.2018.05.009CrossRefPubMed

418.

Alqurashi W, Ellis AK (2017) Do corticosteroids prevent biphasic anaphylaxis? J Allergy Clin Immunol Pract 5(5):1194–1205. https://doi.org/10.1016/j.jaip.2017.05.022CrossRefPubMed

419.

Wang Y, Allen KJ, Suaini NHA, McWilliam V, Peters RL, Koplin JJ (2019) The global incidence and prevalence of anaphylaxis in children in the general population: A systematic review. Allergy 74(6):1063–1080. https://doi.org/10.1111/all.13732CrossRefPubMed

420.

Posner LS, Camargo CA Jr. (2017) Update on the usage and safety of epinephrine auto-injectors, 2017. Drug Healthc Patient Saf 9:9–18. https://doi.org/10.2147/DHPS.S121733CrossRefPubMedPubMedCentral

421.

Tanno LK, Alvarez-Perea A, Pouessel G (2019) Therapeutic approach of anaphylaxis. Curr Opin Allergy Clin Immunol 19(4):393–401. https://doi.org/10.1097/ACI.0000000000000539CrossRefPubMed

422.

Anagnostou K (2018) Anaphylaxis in children: epidemiology, risk factors and management. Curr Pediatr Rev 14(3):180–186. https://doi.org/10.2174/1573396314666180507115115CrossRefPubMed

423.

Farbman KS, Michelson KA (2016) Anaphylaxis in children. Curr Opin Pediatr 28(3):294–297. https://doi.org/10.1097/MOP.0000000000000340CrossRefPubMedPubMedCentral

424.

Simons FE, Sampson HA (2015) Anaphylaxis: unique aspects of clinical diagnosis and management in infants (birth to age 2 years). J Allergy Clin Immunol 135(5):1125–1131. https://doi.org/10.1016/j.jaci.2014.09.014CrossRefPubMed

425.

Gabrielli S, Clarke A, Morris J et al (2019) Evaluation of prehospital management in a Canadian emergency department anaphylaxis cohort. J Allergy Clin Immunol Pract 7(7):2232–2238e3. https://doi.org/10.1016/j.jaip.2019.04.018CrossRefPubMed

426.

Krmpotic K, Weisser C, O’Hanley A, Soder C (2019) Incidence and outcomes of severe anaphylaxis in paediatric patients in atlantic Canada. J Pediatr Intensive Care 8(2):113–116. https://doi.org/10.1055/s-0039-1683869CrossRefPubMedPubMedCentral

427.

Maa T, Scherzer DJ, Harwayne-Gidansky I et al (2020) Prevalence of errors in anaphylaxis in kids (PEAK): a multicenter simulation-based study. J Allergy Clin Immunol Pract 8(4):1239–1246e3. https://doi.org/10.1016/j.jaip.2019.11.013CrossRefPubMed

428.

Choi YJ, Kim J, Jung JY, Kwon H, Park JW (2019) Underuse of epinephrine for pediatric anaphylaxis victims in the emergency department: a population-based study. Allergy Asthma Immunol Res 11(4):529–537. https://doi.org/10.4168/aair.2019.11.4.529CrossRefPubMedPubMedCentral

429.

Cohen N, Capua T, Pivko D, Ben-Shoshan M, Benor S, Rimon A (2018) Trends in the diagnosis and management of anaphylaxis in a tertiary care pediatric emergency department. Ann Allergy Asthma Immunol 121(3):348–352. https://doi.org/10.1016/j.anai.2018.06.033CrossRefPubMed

430.

Ruiz Oropeza A, Lassen A, Halken S, Bindslev-Jensen C, Mortz CG (2017) Anaphylaxis in an emergency care setting: a one year prospective study in children and adults. Scand J Trauma Resusc Emerg Med 25(1):111. https://doi.org/10.1186/s13049-017-0402-0CrossRefPubMedPubMedCentral

431.

Michelson KA, Monuteaux MC, Neuman MI (2015) Glucocorticoids and hospital length of stay for children with anaphylaxis: a retrospective study. J Pediatr 167(3):719–724.e1–3. https://doi.org/10.1016/j.jpeds.2015.05.033CrossRefPubMed

432.

Fleming JT, Clark S, Camargo CA Jr., Rudders SA (2015) Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization. J Allergy Clin Immunol Pract 3(1):57–62. https://doi.org/10.1016/j.jaip.2014.07.004CrossRefPubMed

433.

van der Valk JPM, Berends I, Gerth van Wijk R et al (2018) Small percentage of anaphylactic reactions treated with epinephrine during food challenges in Dutch children. Ann Allergy Asthma Immunol 120(3):300–303. https://doi.org/10.1016/j.anai.2017.08.018CrossRefPubMed

434.

Ninchoji T, Iwatani S, Nishiyama M et al (2018) Current situation of treatment for anaphylaxis in a Japanese pediatric emergency center. Pediatr Emerg Care 34(4):e64–e67. https://doi.org/10.1097/PEC.0000000000000691CrossRefPubMed

435.

Dubus JC, Le MS, Vitte J et al (2019) Use of epinephrine in emergency department depends on anaphylaxis severity in children. Eur J Pediatr 178(1):69–75. https://doi.org/10.1007/s00431-018-3246-3CrossRefPubMed

436.

Sidhu N, Jones S, Perry T et al (2016) Evaluation of anaphylaxis management in a pediatric emergency department. Pediatr Emerg Care 32(8):508–513. https://doi.org/10.1097/PEC.0000000000000864CrossRefPubMed

437.

Robinson M, Greenhawt M, Stukus DR (2017) Factors associated with epinephrine administration for anaphylaxis in children before arrival to the emergency department. Ann Allergy Asthma Immunol 119(2):164–169. https://doi.org/10.1016/j.anai.2017.06.001CrossRefPubMed

438.

Latimer AJ, Husain S, Nolan J et al (2018) Syringe administration of epinephrine by emergency medical technicians for anaphylaxis. Prehosp Emerg Care 22(3):319–325. https://doi.org/10.1080/10903127.2017.1392667CrossRefPubMed

439.

Cristiano LM, Hiestand B, Caldwell JW et al (2018) Prehospital administration of epinephrine in pediatric anaphylaxis—a statewide perspective. Prehosp Emerg Care 22(4):452–456. https://doi.org/10.1080/10903127.2017.1399184CrossRefPubMed

440.

Carrillo E, Hern HG, Barger J (2016) Prehospital administration of epinephrine in pediatric anaphylaxis. Prehosp Emerg Care 20(2):239–244. https://doi.org/10.3109/10903127.2015.1086843CrossRefPubMed

441.

Andrew E, Nehme Z, Bernard S, Smith K (2018) Pediatric anaphylaxis in the prehospital setting: incidence, characteristics, and management. Prehosp Emerg Care 22(4):445–451. https://doi.org/10.1080/10903127.2017.1402110CrossRefPubMed

442.

Kim L, Nevis IF, Tsai G et al (2014) Children under 15 kg with food allergy may be at risk of having epinephrine auto-injectors administered into bone. Allergy Asthma Clin Immunol 10(1):40. https://doi.org/10.1186/1710-1492-10-40CrossRefPubMedPubMedCentral

443.

Topal E, Bakirtas A, Yilmaz O et al (2013) Anaphylaxis in infancy compared with older children. Allergy Asthma Proc 34(3):233–238. https://doi.org/10.2500/aap.2013.34.3658CrossRefPubMed

444.

Grabenhenrich LB, Dolle S, Moneret-Vautrin A et al (2016) Anaphylaxis in children and adolescents: the European Anaphylaxis Registry. J Allergy Clin Immunol 137(4):1128–1137e1. https://doi.org/10.1016/j.jaci.2015.11.015CrossRefPubMed

445.

Loprinzi Brauer CE, Motosue MS, Li JT et al (2016) Prospective validation of the NIAID/FAAN criteria for emergency department diagnosis of Anaphylaxis. J Allergy Clin Immunol Pract 4(6):1220–1226. https://doi.org/10.1016/j.jaip.2016.06.003CrossRefPubMed

446.

Mintegi S, Azkunaga B, Prego J et al (2019) International epidemiological differences in acute poisonings in pediatric emergency departments. Pediatr Emerg Care 35(1):50–57. https://doi.org/10.1097/PEC.0000000000001031CrossRefPubMed

447.

Avau B, Borra V, Vanhove AC, Vandekerckhove P, De Paepe P, De Buck E (2018) First aid interventions by laypeople for acute oral poisoning. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD013230CrossRefPubMedPubMedCentral

448.

Mintegi S, Dalziel SR, Azkunaga B et al (2017) International variability in gastrointestinal decontamination with acute poisonings. Pediatrics. https://doi.org/10.1542/peds.2017-0006CrossRefPubMed

449.

Quinn N, Palmer CS, Bernard S, Noonan M, Teague WJ (2020) Thoracostomy in children with severe trauma: an overview of the paediatric experience in Victoria, Australia. Emerg Med Australas 32(1):117–126. https://doi.org/10.1111/1742-6723.13392CrossRefPubMed

450.

Terboven T, Leonhard G, Wessel L et al (2019) Chest wall thickness and depth to vital structures in paediatric patients—implications for prehospital needle decompression of tension pneumothorax. Scand J Trauma Resusc Emerg Med 27(1):45. https://doi.org/10.1186/s13049-019-0623-5CrossRefPubMedPubMedCentral

451.

Leonhard G, Overhoff D, Wessel L et al (2019) Determining optimal needle size for decompression of tension pneumothorax in children—a CT-based study. Scand J Trauma Resusc Emerg Med 27(1):90. https://doi.org/10.1186/s13049-019-0671-xCrossRefPubMedPubMedCentral

452.

Pelland-Marcotte MC, Tucker C, Klaassen A et al (2019) Outcomes and risk factors of massive and submassive pulmonary embolism in children: a retrospective cohort study. Lancet Haematol 6(3):e144–e153. https://doi.org/10.1016/S2352-3026(18)30224-2CrossRefPubMed

453.

Morgan JK, Brown J, Bray RM (2018) Resilience as a moderating factor between stress and alcohol-related consequences in the Army National Guard. Addict Behav 80:22–27. https://doi.org/10.1016/j.addbeh.2018.01.002CrossRefPubMed

454.

Belsky J, Warren P, Stanek J, Kumar R (2020) Catheter-directed thrombolysis for submassive pulmonary embolism in children: a case series. Pediatr Blood Cancer 67(4):e28144. https://doi.org/10.1002/pbc.28144CrossRefPubMed

455.

Akam-Venkata J, Forbes TJ, Schreiber T et al (2018) Catheter-directed therapy for acute pulmonary embolism in children. Cardiol Young. https://doi.org/10.1017/S1047951118002135CrossRefPubMed

456.

Kayashima K (2015) Factors affecting survival in pediatric cardiac tamponade caused by central venous catheters. J Anesth 29(6):944–952. https://doi.org/10.1007/s00540-015-2045-5CrossRefPubMed

457.

Jat KR, Lodha R, Kabra SK (2011) Arrhythmias in children. Indian J Pediatr 78(2):211–218. https://doi.org/10.1007/s12098-010-0276-xCrossRefPubMed

458.

Baruteau AE, Perry JC, Sanatani S, Horie M, Dubin AM (2016) Evaluation and management of bradycardia in neonates and children. Eur J Pediatr 175(2):151–161. https://doi.org/10.1007/s00431-015-2689-zCrossRefPubMed

459.

Eisa L, Passi Y, Lerman J, Raczka M, Heard C (2015) Do small doses of atropine (〈0.1 mg) cause bradycardia in young children? Arch Dis Child 100(7):684–688. https://doi.org/10.1136/archdischild-2014-307868CrossRefPubMed

460.

Brugada J, Blom N, Sarquella-Brugada G et al (2013) Pharmacological and non-pharmacological therapy for arrhythmias in the pediatric population: EHRA and AEPC-Arrhythmia Working Group joint consensus statement. Europace 15(9):1337–1382. https://doi.org/10.1093/europace/eut082CrossRefPubMed

461.

Brugada J, Katritsis DG, Arbelo E et al (2020) 2019 ESC Guidelines for the management of patients with supraventricular tachycardiaThe Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC). Eur Heart J 41(5):655–720. https://doi.org/10.1093/eurheartj/ehz467CrossRefPubMed

462.

BET 1: Intraosseous adenosine for the termination of paroxysmal supraventricular tachycardia in children. Emergency Medicine 2014;31(7):604–605. https://doi.org/10.1136/emermed-2014-203947.1.

463.

Quail MA, Till J (2012) Question 3 Does a higher initial dose of adenosine improve cardioversion rates in supraventricular tachycardia? Arch Dis Child 97(2):177–179. https://doi.org/10.1136/archdischild-2011-301079CrossRefPubMed

464.

Campbell M, Buitrago SR (2017) BET 2: Ice water immersion, other vagal manoeuvres or adenosine for SVT in children. Emerg Med Clin North Am 34(1):58–60. https://doi.org/10.1136/emermed-2016-206487.2CrossRef

465.

Richardson C, Silver ES (2017) Management of supraventricular tachycardia in infants. Paediatr Drugs 19(6):539–551. https://doi.org/10.1007/s40272-017-0254-0CrossRefPubMed

466.

Bronzetti G, Brighenti M, Mariucci E et al (2018) Upside-down position for the out of hospital management of children with supraventricular tachycardia. Int J Cardiol 252:106–109. https://doi.org/10.1016/j.ijcard.2017.10.120CrossRefPubMed

467.

Gill BU, Bukhari SN, Rashid MA, Saleemi MS, Zaffar MZ (2014) Comparing the efficacy of intravenous adenosine and verapamil in termination of acute paroxysmal supra ventricular tachycardia. J Ayub Med Coll Abbottabad 26(1):29–31 (https://www.ncbi.nlm.nih.gov/pubmed/25358211)PubMed

468.

Clausen H, Theophilos T, Jackno K, Babl FE (2012) Paediatric arrhythmias in the emergency department. Emerg Med Clin North Am 29(9):732–737. https://doi.org/10.1136/emermed-2011-200242CrossRef

469.

Chrysostomou C, Morell VO, Wearden P, Sanchez-de-Toledo J, Jooste EH, Beerman L (2013) Dexmedetomidine: therapeutic use for the termination of reentrant supraventricular tachycardia. Congenit Heart Dis 8(1):48–56. https://doi.org/10.1111/j.1747-0803.2012.00669.xCrossRefPubMed

470.

Moffett BS, Lupo PJ, dela Uz CM et al (2015) Efficacy of digoxin in comparison with propranolol for treatment of infant supraventricular tachycardia: analysis of a large, national database. Cardiol Young 25(6):1080–1085. https://doi.org/10.1017/S1047951114001619CrossRefPubMed

471.

Qureshi AU, Hyder SN, Sheikh AM, Sadiq M (2012) Optimal dose of adenosine effective for supraventricular tachycardia in children. J Coll Physicians Surg Pak 22(10):648–651. https://doi.org/10.2012/JCPSP.648651CrossRefPubMed

472.

Chu PY, Hill KD, Clark RH, Smith PB, Hornik CP (2015) Treatment of supraventricular tachycardia in infants: analysis of a large multicenter database. Early Hum Dev 91(6):345–350. https://doi.org/10.1016/j.earlhumdev.2015.04.001CrossRefPubMedPubMedCentral

473.

Diaz-Parra S, Sanchez-Yanez P, Zabala-Arguelles I et al (2014) Use of adenosine in the treatment of supraventricular tachycardia in a pediatric emergency department. Pediatr Emerg Care 30(6):388–393. https://doi.org/10.1097/PEC.0000000000000144CrossRefPubMed

474.

Morello ML, Khoury PR, Knilans TK et al (2018) Risks and outcomes of direct current cardioversion in children and young adults with congenital heart disease. Pacing Clin Electrophysiol 41(5):472–479. https://doi.org/10.1111/pace.13315CrossRefPubMed

475.

Lewis J, Arora G, Tudorascu DL, Hickey RW, Saladino RA, Manole MD (2017) Acute management of refractory and unstable pediatric supraventricular tachycardia. J Pediatr 181:177–182e2. https://doi.org/10.1016/j.jpeds.2016.10.051CrossRefPubMed

476.

Kim JH, Jung JY, Lee SU, Park JW, Choi JY (2020) Delayed adenosine therapy is associated with the refractory supraventricular tachycardia in children. Am J Emerg Med 38(11):2291–2296. https://doi.org/10.1016/j.ajem.2019.10.018CrossRefPubMed

477.

Weberding NT, Saladino RA, Minnigh MB et al (2018) Adenosine administration with a stopcock technique delivers lower-than-intended drug doses. Ann Emerg Med 71(2):220–224. https://doi.org/10.1016/j.annemergmed.2017.09.002CrossRefPubMed

478.

Palatinus JA, Lieber SB, Joyce KE, Richards JB (2015) Extracorporeal membrane oxygenation support for hypokalemia-induced cardiac arrest: a case report and review of the literature. J Emerg Med 49(2):159–164. https://doi.org/10.1016/j.jemermed.2015.02.046CrossRefPubMed

479.

Rehman Siddiqu NU, Merchant Q, Hasan BS et al (2017) Comparison of enteral versus intravenous potassium supplementation in hypokalaemia in paediatric patients in intensive care post cardiac surgery: open-label randomised equivalence trial (EIPS). BMJ Open 7(5):e11179. https://doi.org/10.1136/bmjopen-2016-011179CrossRefPubMedPubMedCentral

480.

Amirnovin R, Lieu P, Imperial-Perez F, Taketomo C, Markovitz BP, Moromisato DY (2020) Safety, efficacy, and timeliness of intravenous potassium chloride replacement protocols in a pediatric cardiothoracic intensive care unit. J Intensive Care Med 35(4):371–377. https://doi.org/10.1177/0885066617752659CrossRefPubMed

481.

Knudson JD, Lowry AW, Price JF, Moffett BS (2013) Response to intravenous potassium chloride supplementation in pediatric cardiac intensive care patients. Pediatr Cardiol 34(4):887–892. https://doi.org/10.1007/s00246-012-0565-4CrossRefPubMed

482.

Varallo FR, Trombotto V, Lucchetta RC, Mastroianni PC (2019) Efficacy and safety of the pharmacotherapy used in the management of hyperkalemia: a systematic review. J Pharm Pract 17(1):1361. https://doi.org/10.18549/PharmPract.2019.1.1361CrossRef

483.

Depret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M (2019) Management of hyperkalemia in the acutely ill patient. Ann Intensive Care 9(1):32. https://doi.org/10.1186/s13613-019-0509-8CrossRefPubMedPubMedCentral

484.

Chime NO, Luo X, McNamara L, Nishisaki A, Hunt EA (2015) A survey demonstrating lack of consensus on the sequence of medications for treatment of hyperkalemia among pediatric critical care providers. Pediatr Crit Care Med 16(5):404–409. https://doi.org/10.1097/PCC.0000000000000384CrossRefPubMed

485.

Howard-Quijano KJ, Stiegler MA, Huang YM, Canales C, Steadman RH (2010) Anesthesiology residents’ performance of pediatric resuscitation during a simulated hyperkalemic cardiac arrest. Anesthesiology 112(4):993–997. https://doi.org/10.1097/ALN.0b013e3181d31fbeCrossRefPubMed

486.

Arnholt AM, Duval-Arnould JM, McNamara LM, Rosen MA, Singh K, Hunt EA (2015) Comparatively evaluating medication preparation sequences for treatment of hyperkalemia in pediatric cardiac arrest: a prospective, randomized, simulation-based study. Pediatr Crit Care Med 16(7):e224–e230. https://doi.org/10.1097/PCC.0000000000000497CrossRefPubMed

487.

Lee J, Moffett BS (2016) Treatment of pediatric hyperkalemia with sodium polystyrene sulfonate. Pediatr Nephrol 31(11):2113–2117. https://doi.org/10.1007/s00467-016-3414-5CrossRefPubMed

488.

Abraham MB, Jones TW, Naranjo D et al (2018) ISPAD clinical practice consensus guidelines 2018: assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes 19(Suppl 27):178–192. https://doi.org/10.1111/pedi.12698CrossRefPubMed

489.

Weston PJ, Harris DL, Battin M, Brown J, Hegarty JE, Harding JE (2016) Oral dextrose gel for the treatment of hypoglycaemia in newborn infants. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD011027.pub2CrossRefPubMedPubMedCentral

490.

De Buck E, Borra V, Carlson JN, Zideman DA, Singletary EM, Djarv T (2019) First aid glucose administration routes for symptomatic hypoglycaemia. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD013283.pub2CrossRefPubMedPubMedCentral

491.

Kim SY (2015) Endocrine and metabolic emergencies in children: hypocalcemia, hypoglycemia, adrenal insufficiency, and metabolic acidosis including diabetic ketoacidosis. Ann Pediatr Endocrinol Metab 20(4):179–186. https://doi.org/10.6065/apem.2015.20.4.179CrossRefPubMedPubMedCentral

492.

Rostykus P, Kennel J, Adair K et al (2016) Variability in the treatment of prehospital hypoglycemia: a structured review of EMS protocols in the United States. Prehosp Emerg Care 20(4):524–530. https://doi.org/10.3109/10903127.2015.1128031CrossRefPubMed

493.

Remick K, Redgate C, Ostermayer D, Kaji AH, Gausche-Hill M (2017) Prehospital glucose testing for children with seizures: a proposed change in management. Prehosp Emerg Care 21(2):216–221. https://doi.org/10.1080/10903127.2016.1218979CrossRefPubMed

494.

Walsh BM, Gangadharan S, Whitfill T et al (2017) Safety threats during the care of infants with hypoglycemic seizures in the emergency department: a multicenter, simulation-based prospective cohort study. J Emerg Med 53(4):467–474e7. https://doi.org/10.1016/j.jemermed.2017.04.028CrossRefPubMed

495.

Sherr JL, Ruedy KJ, Foster NC et al (2016) Glucagon nasal powder: a promising alternative to Intramuscular Glucagon in youth with type 1 diabetes. Diabetes Care 39(4):555–562. https://doi.org/10.2337/dc15-1606CrossRefPubMedPubMedCentral

496.

Singletary EM, Zideman DA, Bendall JC et al (2020) 2020 international consensus on first aid science with treatment recommendations. Resuscitation 156:A240–A282. https://doi.org/10.1016/j.resuscitation.2020.09.016CrossRefPubMed

497.

Lipman GS, Gaudio FG, Eifling KP, Ellis MA, Otten EM, Grissom CK (2019) Wilderness medical society clinical practice guidelines for the prevention and treatment of heat illness: 2019 update. Wilderness Environ Med 30(4S):S33–S46. https://doi.org/10.1016/j.wem.2018.10.004CrossRefPubMed

498.

Tate RC, Selde W (2013) Heat trap. How to treat vehicular hyperthermia in children. JEMS 38(7):36–38, 40, 42 (https://www.ncbi.nlm.nih.gov/pubmed/24159737)PubMed

499.

Rosenberg H, Pollock N, Schiemann A, Bulger T, Stowell K (2015) Malignant hyperthermia: a review. Orphanet J Rare Dis 10:93. https://doi.org/10.1186/s13023-015-0310-1CrossRefPubMedPubMedCentral

500.

Jardine DS (2007) Heat illness and heat stroke. Pediatr Rev 28(7):249–258. https://doi.org/10.1542/pir.28-7-249CrossRefPubMed

501.

Nelson P, Litman RS (2014) Malignant hyperthermia in children: an analysis of the North American malignant hyperthermia registry. Anesth Analg 118(2):369–374. https://doi.org/10.1213/ANE.0b013e3182a8fad0CrossRefPubMed

502.

Adato B, Dubnov-Raz G, Gips H, Heled Y, Epstein Y (2016) Fatal heat stroke in children found in parked cars: autopsy findings. Eur J Pediatr 175(9):1249–1252. https://doi.org/10.1007/s00431-016-2751-5CrossRefPubMed

503.

Natsume J, Hamano SI, Iyoda K et al (2017) New guidelines for management of febrile seizures in Japan. Brain Dev 39(1):2–9. https://doi.org/10.1016/j.braindev.2016.06.003CrossRefPubMed

504.

Glauser T, Shinnar S, Gloss D et al (2016) Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the guideline committee of the American Epilepsy Society. Epilepsy Curr 16(1):48–61. https://doi.org/10.5698/1535-7597-16.1.48CrossRefPubMedPubMedCentral

505.

Health NSW Infants and children—acute management of seizures. New South Wales health. https://www1.health.nsw.gov.au/pds/ActivePDSDocuments/GL2018_015.pdf (Erstellt: 7. Juni 2018)

506.

Li L, Zhang Y, Jia L et al (2020) Levetiracetam versus phenytoin for the treatment of established status epilepticus: a systematic review and meta-analysis of randomized controlled trials. Seizure 78:43–48. https://doi.org/10.1016/j.seizure.2020.03.002CrossRefPubMed

507.

Chen D, Bian H, Zhang L (2019) A meta-analysis of levetiracetam for randomized placebo-controlled trials in patients with refractory epilepsy. Neuropsychiatr Dis Treat 15:905–917. https://doi.org/10.2147/NDT.S188111CrossRefPubMedPubMedCentral

508.

Sanchez Fernandez I, Gainza-Lein M, Lamb N, Loddenkemper T (2019) Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus. Neurology 92(20):e2339–e2348. https://doi.org/10.1212/WNL.0000000000007503CrossRefPubMed

509.

Brigo F, Bragazzi NL, Bacigaluppi S, Nardone R, Trinka E (2016) Is intravenous lorazepam really more effective and safe than intravenous diazepam as first-line treatment for convulsive status epilepticus? A systematic review with meta-analysis of randomized controlled trials. Epilepsy Behav 64(Pt A):29–36. https://doi.org/10.1016/j.yebeh.2016.09.020CrossRefPubMed

510.

Ortiz de la Rosa JS, Ladino LD, Rodriguez PJ, Rueda MC, Polania JP, Castaneda AC (2018) Efficacy of lacosamide in children and adolescents with drug-resistant epilepsy and refractory status epilepticus: a systematic review. Seizure 56:34–40. https://doi.org/10.1016/j.seizure.2018.01.014CrossRefPubMed

511.

Uppal P, Cardamone M, Lawson JA (2018) Outcomes of deviation from treatment guidelines in status epilepticus: a systematic review. Seizure 58:147–153. https://doi.org/10.1016/j.seizure.2018.04.005CrossRefPubMed

512.

Au CC, Branco RG, Tasker RC (2017) Management protocols for status epilepticus in the pediatric emergency room: systematic review article. J Pediatr 93(Suppl 1):84–94. https://doi.org/10.1016/j.jped.2017.08.004CrossRef

513.

Zhao ZY, Wang HY, Wen B, Yang ZB, Feng K, Fan JC (2016) A comparison of Midazolam, Lorazepam, and diazepam for the treatment of status epilepticus in children: a network meta-analysis. J Child Neurol 31(9):1093–1107. https://doi.org/10.1177/0883073816638757CrossRefPubMed

514.

Trinka E, Hofler J, Zerbs A, Brigo F (2014) Efficacy and safety of intravenous valproate for status epilepticus: a systematic review. CNS Drugs 28(7):623–639. https://doi.org/10.1007/s40263-014-0167-1CrossRefPubMedPubMedCentral

515.

Strzelczyk A, Zollner JP, Willems LM et al (2017) Lacosamide in status epilepticus: systematic review of current evidence. Epilepsia 58(6):933–950. https://doi.org/10.1111/epi.13716CrossRefPubMed

516.

Jain P, Sharma S, Dua T, Barbui C, Das RR, Aneja S (2016) Efficacy and safety of anti-epileptic drugs in patients with active convulsive seizures when no IV access is available: systematic review and meta-analysis. Epilepsy Res 122:47–55. https://doi.org/10.1016/j.eplepsyres.2016.02.006CrossRefPubMed

517.

McTague A, Martland T, Appleton R (2018) Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD001905.pub3CrossRefPubMedPubMedCentral

518.

Alshehri A, Abulaban A, Bokhari R et al (2017) Intravenous versus nonintravenous benzodiazepines for the cessation of seizures: a systematic review and meta-analysis of randomized controlled trials. Acad Emerg Med 24(7):875–883. https://doi.org/10.1111/acem.13190CrossRefPubMed

519.

Sanchez Fernandez I, Goodkin HP, Scott RC (2019) Pathophysiology of convulsive status epilepticus. Seizure 68:16–21. https://doi.org/10.1016/j.seizure.2018.08.002CrossRefPubMed

520.

Ciccone O, Mathews M, Birbeck GL (2017) Management of acute seizures in children: a review with special consideration of care in resource-limited settings. Afr J Emerg Med 7(Suppl):S3–S9. https://doi.org/10.1016/j.afjem.2017.09.003CrossRefPubMedPubMedCentral

521.

Silverman EC, Sporer KA, Lemieux JM et al (2017) Prehospital care for the adult and pediatric seizure patient: current evidence-based recommendations. West J Emerg Med 18(3):419–436. https://doi.org/10.5811/westjem.2016.12.32066CrossRefPubMedPubMedCentral

522.

Lawton B, Davis T, Goldstein H, Tagg A (2018) An update in the initial management of paediatric status epilepticus. Curr Opin Pediatr 30(3):359–363. https://doi.org/10.1097/MOP.0000000000000616CrossRefPubMed

523.

Stredny CM, Abend NS, Loddenkemper T (2018) Towards acute pediatric status epilepticus intervention teams: do we need “Seizure Codes”? Seizure 58:133–140. https://doi.org/10.1016/j.seizure.2018.04.011CrossRefPubMed

524.

Smith DM, McGinnis EL, Walleigh DJ, Abend NS (2016) Management of status epilepticus in children. J Clin Med. https://doi.org/10.3390/jcm5040047CrossRefPubMedPubMedCentral

525.

Kapur J, Elm J, Chamberlain JM et al (2019) Randomized trial of three anticonvulsant medications for status epilepticus. N Engl J Med 381(22):2103–2113. https://doi.org/10.1056/NEJMoa1905795CrossRefPubMedPubMedCentral

526.

Alansari K, Barkat M, Mohamed AH, Al Jawala SA, Othman SA (2020) Intramuscular versus buccal midazolam for pediatric seizures: a randomized double-blinded trial. Pediatr Neurol 109:28–34. https://doi.org/10.1016/j.pediatrneurol.2020.03.011CrossRefPubMed

527.

Vignesh V, Rameshkumar R, Mahadevan S (2020) Comparison of Phenytoin, Valproate and Levetiracetam in pediatric convulsive status Epilepticus: a randomized double-blind controlled clinical trial. Indian Pediatr 57(3):222–227 (https://www.ncbi.nlm.nih.gov/pubmed/32198861)CrossRefPubMed

528.

Chamberlain JM, Kapur J, Shinnar S et al (2020) Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial. Lancet 395(10231):1217–1224. https://doi.org/10.1016/S0140-6736(20)30611-5CrossRefPubMedPubMedCentral

529.

Chamberlain DB, Chamberlain JM (2017) Making sense of a negative clinical trial result: a Bayesian analysis of a clinical trial of lorazepam and diazepam for pediatric status epilepticus. Ann Emerg Med 69(1):117–124. https://doi.org/10.1016/j.annemergmed.2016.08.449CrossRefPubMed

530.

Portela JL, Garcia PC, Piva JP et al (2015) Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. Med Intensiva 39(3):160–166. https://doi.org/10.1016/j.medin.2014.04.003CrossRefPubMed

531.

Singh K, Aggarwal A, Faridi MMA, Sharma S (2018) IV Levetiracetam versus IV phenytoin in childhood seizures: a randomized controlled trial. J Pediatr Neurosci 13(2):158–164. https://doi.org/10.4103/jpn.JPN_126_17CrossRefPubMedPubMedCentral

532.

Khajeh A, Yaghoubinia F, Yaghoubi S, Fayyazi A, Miri Aliabad G (2018) Comparison of the effect of phenobarbital versus sodium Valproate in management of children with status epilepticus. Iran J Child Neurol 12(4):85–93 (https://www.ncbi.nlm.nih.gov/pubmed/30279711)PubMedPubMedCentral

533.

Lyttle MD, Rainford NEA, Gamble C et al (2019) Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial. Lancet 393(10186):2125–2134. https://doi.org/10.1016/S0140-6736(19)30724-XCrossRefPubMedPubMedCentral

534.

Birbeck GL, Herman ST, Capparelli EV et al (2019) A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. BMC Pediatr 19(1):399. https://doi.org/10.1186/s12887-019-1766-2CrossRefPubMedPubMedCentral

535.

Wani G, Imran A, Dhawan N, Gupta A, Giri JI (2019) Levetiracetam versus phenytoin in children with status epilepticus. J Family Med Prim Care 8(10):3367–3371. https://doi.org/10.4103/jfmpc.jfmpc_750_19CrossRefPubMedPubMedCentral

536.

Silbergleit R, Elm JJ (2019) Levetiracetam no better than phenytoin in children with convulsive status epilepticus. Lancet 393(10186):2101–2102. https://doi.org/10.1016/S0140-6736(19)30896-7CrossRefPubMed

537.

Momen AA, Azizi Malamiri R, Nikkhah A et al (2015) Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children. Eur J Paediatr Neurol 19(2):149–154. https://doi.org/10.1016/j.ejpn.2014.11.007CrossRefPubMed

538.

Welch RD, Nicholas K, Durkalski-Mauldin VL et al (2015) Intramuscular midazolam versus intravenous lorazepam for the prehospital treatment of status epilepticus in the pediatric population. Epilepsia 56(2):254–262. https://doi.org/10.1111/epi.12905CrossRefPubMedPubMedCentral

539.

Burman RJ, Ackermann S, Shapson-Coe A, Ndondo A, Buys H, Wilmshurst JM (2019) A comparison of parenteral phenobarbital vs. parenteral phenytoin as second-line management for pediatric convulsive status Epilepticus in a resource-limited setting. Front Neurol 10:506. https://doi.org/10.3389/fneur.2019.00506CrossRefPubMedPubMedCentral

540.

Noureen N, Khan S, Khursheed A et al (2019) Clinical efficacy and safety of injectable levetiracetam versus phenytoin as second-line therapy in the management of generalized convulsive status Epilepticus in children: an open-label randomized controlled trial. J Clin Neurol 15(4):468–472. https://doi.org/10.3988/jcn.2019.15.4.468CrossRefPubMedPubMedCentral

541.

Dalziel SR, Borland ML, Furyk J et al (2019) Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial. Lancet 393(10186):2135–2145. https://doi.org/10.1016/S0140-6736(19)30722-6CrossRefPubMed

542.

Chiarello D, Duranti F, Lividini A et al (2020) Clinical characterization of status epilepticus in childhood: a retrospective study in 124 patients. Seizure 78:127–133. https://doi.org/10.1016/j.seizure.2020.03.019CrossRefPubMed

543.

Wang T, Wang J, Dou Y et al (2020) Clinical characteristics and prognosis in a large paediatric cohort with status epilepticus. Seizure 80:5–11. https://doi.org/10.1016/j.seizure.2020.04.001CrossRefPubMed

544.

Sanchez Fernandez I, Abend NS, Agadi S et al (2015) Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology 84(23):2304–2311. https://doi.org/10.1212/WNL.0000000000001673CrossRefPubMedPubMedCentral

545.

Lee YJ, Yum MS, Kim EH, Ko TS (2016) Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures. Korean J Pediatr 59(1):35–39. https://doi.org/10.3345/kjp.2016.59.1.35CrossRefPubMedPubMedCentral

546.

Incecik F, Horoz OO, Herguner OM et al (2016) Intravenous levetiracetam in critically ill children. Ann Indian Acad Neurol 19(1):79–82. https://doi.org/10.4103/0972-2327.167702CrossRefPubMedPubMedCentral

547.

Johnson PN, Nguyen A, Neely SB, Johnson M (2017) Intramuscular Lorazepam for status epilepticus in children with complex medical and physical disabilities. Ann Pharmacother 51(8):656–662. https://doi.org/10.1177/1060028017706522CrossRefPubMed

548.

Santhanam I, Yoganathan S, Sivakumar VA, Ramakrishnamurugan R, Sathish S, Thandavarayan M (2017) Predictors of outcome in children with status epilepticus during resuscitation in pediatric emergency department: a retrospective observational study. Ann Indian Acad Neurol 20(2):142–148. https://doi.org/10.4103/aian.AIAN_369_16CrossRefPubMedPubMedCentral

549.

Nishiyama M, Nagase H, Tomioka K et al (2018) Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus. Brain Dev 40(10):884–890. https://doi.org/10.1016/j.braindev.2018.08.001CrossRefPubMed

550.

Ulusoy E, Duman M, Turker HD et al (2019) The effect of early midazolam infusion on the duration of pediatric status epilepticus patients. Seizure 71:50–55. https://doi.org/10.1016/j.seizure.2019.06.011CrossRefPubMed

551.

Theusinger OM, Schenk P, Dette-Oltmann K, Mariotti S, Baulig W (2019) Treatment of seizures in children and adults in the emergency medical system of the city of zurich, Switzerland—Midazolam vs. Diazepam—a retrospective analysis. J Emerg Med 57(3):345–353. https://doi.org/10.1016/j.jemermed.2019.05.036CrossRefPubMed

552.

Tasker RC, Goodkin HP, Sanchez Fernandez I et al (2016) Refractory status epilepticus in children: intention to treat with continuous infusions of Midazolam and pentobarbital. Pediatr Crit Care Med 17(10):968–975. https://doi.org/10.1097/PCC.0000000000000900CrossRefPubMedPubMedCentral

553.

Shtull-Leber E, Silbergleit R, Meurer WJ (2017) Pre-hospital midazolam for benzodiazepine-treated seizures before and after the rapid anticonvulsant medication prior to arrival trial: a national observational cohort study. Plos One 12(3):e173539. https://doi.org/10.1371/journal.pone.0173539CrossRefPubMedPubMedCentral

554.

Gurcharran K, Grinspan ZM (2019) The burden of pediatric status epilepticus: epidemiology, morbidity, mortality, and costs. Seizure 68:3–8. https://doi.org/10.1016/j.seizure.2018.08.021CrossRefPubMed

555.

Isguder R, Guzel O, Ceylan G, Yilmaz U, Agin H (2016) A comparison of intravenous levetiracetam and valproate for the treatment of refractory status epilepticus in children. J Child Neurol 31(9):1120–1126. https://doi.org/10.1177/0883073816641187CrossRefPubMed

556.

Olasveengen TM, Mancini ME, Perkins GD et al (2020) Adult basic life support: international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 156:A35–A79. https://doi.org/10.1016/j.resuscitation.2020.09.010CrossRefPubMedPubMedCentral

557.

Zhan L, Yang LJ, Huang Y, He Q, Liu GJ (2017) Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non-asphyxial out-of-hospital cardiac arrest. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD010134.pub2CrossRefPubMedPubMedCentral

558.

Maeda T, Yamashita A, Myojo Y, Wato Y, Inaba H (2016) Augmented survival of out-of-hospital cardiac arrest victims with the use of mobile phones for emergency communication under the DA-CPR protocol getting information from callers beside the victim. Resuscitation 107:80–87. https://doi.org/10.1016/j.resuscitation.2016.08.010CrossRefPubMed

559.

Steensberg AT, Eriksen MM, Andersen LB et al (2017) Bystander capability to activate speaker function for continuous dispatcher assisted CPR in case of suspected cardiac arrest. Resuscitation 115:52–55. https://doi.org/10.1016/j.resuscitation.2017.04.002CrossRefPubMed

560.

Mortensen RB, Hoyer CB, Pedersen MK, Brindley PG, Nielsen JC (2010) Comparison of the quality of chest compressions on a dressed versus an undressed manikin: a controlled, randomised, cross-over simulation study. Scand J Trauma Resusc Emerg Med 18:16. https://doi.org/10.1186/1757-7241-18-16CrossRefPubMedPubMedCentral

561.

Birkenes TS, Myklebust H, Kramer-Johansen J (2013) Time delays and capability of elderly to activate speaker function for continuous telephone CPR. Scand J Trauma Resusc Emerg Med 21:40. https://doi.org/10.1186/1757-7241-21-40CrossRefPubMedPubMedCentral

562.

Eisenberg Chavez D, Meischke H, Painter I, Rea TD (2013) Should dispatchers instruct lay bystanders to undress patients before performing CPR? A randomized simulation study. Resuscitation 84(7):979–981. https://doi.org/10.1016/j.resuscitation.2012.12.010CrossRefPubMed

563.

Tobin JM, Ramos WD, Greenshields J et al (2020) Outcome of conventional bystander cardiopulmonary resuscitation in cardiac arrest following drowning. Prehosp Disaster med 35(2):141–147. https://doi.org/10.1017/S1049023X20000060CrossRefPubMed

564.

Naim MY, Burke RV, McNally BF et al (2017) Association of bystander cardiopulmonary resuscitation with overall and neurologically favorable survival after pediatric out-of-hospital cardiac arrest in the United States: a report from the cardiac arrest registry to enhance survival surveillance registry. JAMA Pediatr 171(2):133–141. https://doi.org/10.1001/jamapediatrics.2016.3643CrossRefPubMed

565.

Fukuda T, Ohashi-Fukuda N, Kobayashi H et al (2016) Conventional versus compression-only versus no-bystander cardiopulmonary resuscitation for pediatric out-of-hospital cardiac arrest. Circulation 134(25):2060–2070. https://doi.org/10.1161/CIRCULATIONAHA.116.023831CrossRefPubMed

566.

Sutton RM, Reeder RW, Landis WP et al (2019) Ventilation rates and pediatric in-hospital cardiac arrest survival outcomes. Crit Care Med 47(11):1627–1636. https://doi.org/10.1097/CCM.0000000000003898CrossRefPubMedPubMedCentral

567.

Derkenne C, Jost D, Thabouillot O et al (2020) Improving emergency call detection of out-of-hospital cardiac arrests in the greater paris area: efficiency of a global system with a new method of detection. Resuscitation 146:34–42. https://doi.org/10.1016/j.resuscitation.2019.10.038CrossRefPubMed

568.

Donoghue AJ, Kou M, Good GL et al (2020) Impact of personal protective equipment on pediatric cardiopulmonary resuscitation performance: a controlled trial. Pediatr Emerg Care 36(6):267–273. https://doi.org/10.1097/PEC.0000000000002109CrossRefPubMedPubMedCentral

569.

De Maio VJ, Osmond MH, Stiell IG et al (2012) Epidemiology of out-of hospital pediatric cardiac arrest due to trauma. Prehosp Emerg Care 16(2):230–236. https://doi.org/10.3109/10903127.2011.640419CrossRefPubMed

570.

Vassallo J, Webster M, Barnard EBG, Lyttle MD, Smith JE, Peruki (2019) Epidemiology and aetiology of paediatric traumatic cardiac arrest in England and Wales. Arch Dis Child 104(5):437–443. https://doi.org/10.1136/archdischild-2018-314985CrossRefPubMed

571.

Deasy C, Bray J, Smith K et al (2012) Paediatric traumatic out-of-hospital cardiac arrests in Melbourne, Australia. Resuscitation 83(4):471–475. https://doi.org/10.1016/j.resuscitation.2011.11.009CrossRefPubMed

572.

Barnard EBG, Sandbach DD, Nicholls TL, Wilson AW, Ercole A (2019) Prehospital determinants of successful resuscitation after traumatic and non-traumatic out-of-hospital cardiac arrest. Emerg Med Clin North Am 36(6):333–339. https://doi.org/10.1136/emermed-2018-208165CrossRef

573.

Lu CH, Fang PH, Lin CH (2019) Dispatcher-assisted cardiopulmonary resuscitation for traumatic patients with out-of-hospital cardiac arrest. Scand J Trauma Resusc Emerg Med 27(1):97. https://doi.org/10.1186/s13049-019-0679-2CrossRefPubMedPubMedCentral

574.

Balhara KS, Bustamante ND, Selvam A et al (2019) Bystander assistance for trauma victims in low- and middle-income countries: a systematic review of prevalence and training interventions. Prehosp Emerg Care 23(3):389–410. https://doi.org/10.1080/10903127.2018.1513104CrossRefPubMed

575.

Lin CH, Chiang WC, Ma MH, Wu SY, Tsai MC, Chi CH (2013) Use of automated external defibrillators in patients with traumatic out-of-hospital cardiac arrest. Resuscitation 84(5):586–591. https://doi.org/10.1016/j.resuscitation.2012.09.028CrossRefPubMed

576.

Tibballs J, Weeranatna C (2010) The influence of time on the accuracy of healthcare personnel to diagnose paediatric cardiac arrest by pulse palpation. Resuscitation 81(6):671–675. https://doi.org/10.1016/j.resuscitation.2010.01.030 (In Eng)CrossRefPubMed

577.

O’Connell KJ, Keane RR, Cochrane NH et al (2019) Pauses in compressions during pediatric CPR: Opportunities for improving CPR quality. Resuscitation 145:158–165. https://doi.org/10.1016/j.resuscitation.2019.08.015CrossRefPubMed

578.

Donoghue A, Berg RA, Hazinski MF, Praestgaard AH, Roberts K, Nadkarni VM (2009) Cardiopulmonary resuscitation for bradycardia with poor perfusion versus pulseless cardiac arrest. Pediatrics 124(6):1541–1548. https://doi.org/10.1542/peds.2009-0727 (In eng)CrossRefPubMed

579.

Considine J, Gazmuri RJ, Perkins GD et al (2020) Chest compression components (rate, depth, chest wall recoil and leaning): a scoping review. Resuscitation 146:188–202. https://doi.org/10.1016/j.resuscitation.2019.08.042CrossRefPubMed

580.

Manrique G, Gonzalez A, Iguiniz M et al (2020) Quality of chest compressions during pediatric resuscitation with 15:2 and 30:2 compressions-to-ventilation ratio in a simulated scenario. Sci Rep 10(1):6828. https://doi.org/10.1038/s41598-020-63921-9CrossRefPubMedPubMedCentral

581.

Gregson RK, Cole TJ, Skellett S, Bagkeris E, Welsby D, Peters MJ (2017) Randomised crossover trial of rate feedback and force during chest compressions for paediatric cardiopulmonary resuscitation. Arch Dis Child 102(5):403–409. https://doi.org/10.1136/archdischild-2016-310691CrossRefPubMed

582.

Kandasamy J, Theobald PS, Maconochie IK, Jones MD (2019) Can real-time feedback improve the simulated infant cardiopulmonary resuscitation performance of basic life support and lay rescuers? Arch Dis Child 104(8):793–801. https://doi.org/10.1136/archdischild-2018-316576CrossRefPubMed

583.

Cheng A, Hunt EA, Grant D et al (2015) Variability in quality of chest compressions provided during simulated cardiac arrest across nine pediatric institutions. Resuscitation 97:13–19. https://doi.org/10.1016/j.resuscitation.2015.08.024CrossRefPubMed

584.

Zimmerman E, Cohen N, Maniaci V, Pena B, Lozano JM, Linares M (2015) Use of a metronome in cardiopulmonary resuscitation: a simulation study. Pediatrics 136(5):905–911. https://doi.org/10.1542/peds.2015-1858CrossRefPubMed

585.

Lin Y, Cheng A, Grant VJ, Currie GR, Hecker KG (2018) Improving CPR quality with distributed practice and real-time feedback in pediatric healthcare providers—a randomized controlled trial. Resuscitation 130:6–12. https://doi.org/10.1016/j.resuscitation.2018.06.025CrossRefPubMed

586.

Haque IU, Udassi JP, Udassi S, Theriaque DW, Shuster JJ, Zaritsky AL (2008) Chest compression quality and rescuer fatigue with increased compression to ventilation ratio during single rescuer pediatric CPR. Resuscitation 79(1):82–89. https://doi.org/10.1016/j.resuscitation.2008.04.026 (In eng)CrossRefPubMed

587.

Sutton RM, Reeder RW, Landis W et al (2018) Chest compression rates and pediatric in-hospital cardiac arrest survival outcomes. Resuscitation 130:159–166. https://doi.org/10.1016/j.resuscitation.2018.07.015CrossRefPubMedPubMedCentral

588.

Braga MS, Dominguez TE, Pollock AN et al (2009) Estimation of optimal CPR chest compression depth in children by using computer tomography. Pediatrics 124(1):e69–74. https://doi.org/10.1542/peds.2009-0153 (In eng)CrossRefPubMed

589.

Kao PC, Chiang WC, Yang CW et al (2009) What is the correct depth of chest compression for infants and children? A radiological study. Pediatrics 124(1):49–55. https://doi.org/10.1542/peds.2008-2536 (In eng)CrossRefPubMed

590.

Skogvoll E, Nordseth T, Sutton RM et al (2020) Factors affecting the course of resuscitation from cardiac arrest with pulseless electrical activity in children and adolescents. Resuscitation 152:116–122. https://doi.org/10.1016/j.resuscitation.2020.05.013CrossRefPubMed

591.

Lin CY, Hsia SH, Lee EP, Chan OW, Lin JJ, Wu HP (2020) Effect of audiovisual cardiopulmonary resuscitation feedback device on improving chest compression quality. Sci Rep 10(1):398. https://doi.org/10.1038/s41598-019-57320-yCrossRefPubMedPubMedCentral

592.

Donoghue AJ, Myers S, Kerrey B et al (2020) Analysis of CPR quality by individual providers in the pediatric emergency department. Resuscitation 153:37–44. https://doi.org/10.1016/j.resuscitation.2020.05.026CrossRefPubMed

593.

Jones SI, Jeffers JM, Perretta J et al (2020) Closing the gap: optimizing performance to reduce interruptions in cardiopulmonary resuscitation. Pediatr Crit Care Med 21(9):e592–e598. https://doi.org/10.1097/PCC.0000000000002345CrossRefPubMed

594.

Rodriguez SA, Sutton RM, Berg MD et al (2014) Simplified dispatcher instructions improve bystander chest compression quality during simulated pediatric resuscitation. Resuscitation 85(1):119–123. https://doi.org/10.1016/j.resuscitation.2013.09.003CrossRefPubMed

595.

Kim YH, Lee JH, Cho KW et al (2018) Verification of the optimal chest compression depth for children in the 2015 American Heart Association guidelines: computed tomography study. Pediatr Crit Care Med 19(1):e1–e6. https://doi.org/10.1097/PCC.0000000000001369CrossRefPubMed

596.

Austin AL, Spalding CN, Landa KN et al (2020) A randomized control trial of cardiopulmonary feedback devices and their impact on infant chest compression quality: a simulation study. Pediatr Emerg Care 36(2):e79–e84. https://doi.org/10.1097/PEC.0000000000001312CrossRefPubMed

597.

Enriquez D, Firenze L, Fernandez Diaz J et al (2018) Changes in the depth of chest compressions during cardiopulmonary resuscitation in a pediatric simulator. Arch Argent Pediatr 116(6):e730–e735. https://doi.org/10.5546/aap.2018.eng.e730CrossRefPubMed

598.

Oh JH, Kim SE, Kim CW, Lee DH (2015) Should we change chest compression providers every 2 min when performing one-handed chest compressions? Emerg Med Australas 27(2):108–112. https://doi.org/10.1111/1742-6723.12364CrossRefPubMed

599.

Niles DE, Nishisaki A, Sutton RM et al (2017) Improved retention of chest compression psychomotor skills with brief “rolling refresher” training. Simul Healthc 12(4):213–219. https://doi.org/10.1097/SIH.0000000000000228CrossRefPubMed

600.

Morgan RW, Landis WP, Marquez A et al (2019) Hemodynamic effects of chest compression interruptions during pediatric in-hospital cardiopulmonary resuscitation. Resuscitation 139:1–8. https://doi.org/10.1016/j.resuscitation.2019.03.032CrossRefPubMed

601.

Dezfulian C, Fink EL (2018) How bad is it to fail at pushing hard and fast in pediatric cardiopulmonary resuscitation? Pediatr Crit Care Med 19(5):495–496. https://doi.org/10.1097/PCC.0000000000001529CrossRefPubMedPubMedCentral

602.

Kim MJ, Lee HS, Kim S, Park YS (2015) Optimal chest compression technique for paediatric cardiac arrest victims. Scand J Trauma Resusc Emerg Med 23:36. https://doi.org/10.1186/s13049-015-0118-yCrossRefPubMedPubMedCentral

603.

Mayrand KP, Fischer EJ, Ten Eyck RP (2015) A simulation-based randomized controlled study of factors influencing chest compression depth. West J Emerg Med 16(7):1135–1140. https://doi.org/10.5811/westjem.2015.9.28167CrossRefPubMedPubMedCentral

604.

Millin MG, Bogumil D, Fishe JN, Burke RV (2020) Comparing the two-finger versus two-thumb technique for single person infant CPR: a systematic review and meta-analysis. Resuscitation 148:161–172. https://doi.org/10.1016/j.resuscitation.2019.12.039CrossRefPubMed

605.

Lee JE, Lee J, Oh J et al (2019) Comparison of two-thumb encircling and two-finger technique during infant cardiopulmonary resuscitation with single rescuer in simulation studies: A systematic review and meta-analysis. Medicine 98(45):e17853. https://doi.org/10.1097/MD.0000000000017853CrossRefPubMedPubMedCentral

606.

Douvanas A, Koulouglioti C, Kalafati M (2018) A comparison between the two methods of chest compression in infant and neonatal resuscitation. A review according to 2010 CPR guidelines. J Matern Fetal Neonatal Med 31(6):805–816. https://doi.org/10.1080/14767058.2017.1295953CrossRefPubMed

607.

Lee KH, Kim EY, Park DH et al (2013) Evaluation of the 2010 American Heart Association Guidelines for infant CPR finger/thumb positions for chest compression: a study using computed tomography. Resuscitation 84(6):766–769. https://doi.org/10.1016/j.resuscitation.2012.11.005 (In eng)CrossRefPubMed

608.

Lee SH, Cho YC, Ryu S et al (2011) A comparison of the area of chest compression by the superimposed-thumb and the alongside-thumb techniques for infant cardiopulmonary resuscitation. Resuscitation 82(9):1214–1217. https://doi.org/10.1016/j.resuscitation.2011.04.016CrossRefPubMed

609.

Park M, Oh WS, Chon SB, Cho S (2018) Optimum chest compression point for cardiopulmonary resuscitation in children revisited using a 3D coordinate system imposed on CT: a retrospective, cross-sectional study. Pediatr Crit Care Med 19(11):e576–e584. https://doi.org/10.1097/PCC.0000000000001679CrossRefPubMed

610.

Jang HY, Wolfe H, Hsieh TC et al (2018) Infant chest compression quality: a video-based comparison of two-thumb versus one-hand technique in the emergency department. Resuscitation 122:36–40. https://doi.org/10.1016/j.resuscitation.2017.11.044CrossRefPubMed

611.

Lim JS, Cho Y, Ryu S et al (2013) Comparison of overlapping (OP) and adjacent thumb positions (AP) for cardiac compressions using the encircling method in infants. Emerg Med Clin North Am 30(2):139–142. https://doi.org/10.1136/emermed-2011-200978 (In eng)CrossRef

612.

Jung JY, Kwak YH, Kwon H et al (2017) Effectiveness of finger-marker for maintaining the correct compression point during paediatric resuscitation: a simulation study. Am J Emerg Med 35(9):1303–1308. https://doi.org/10.1016/j.ajem.2017.04.003CrossRefPubMed

613.

Jiang J, Zou Y, Shi W et al (2015) Two-thumb-encircling hands technique is more advisable than 2‑finger technique when lone rescuer performs cardiopulmonary resuscitation on infant manikin. Am J Emerg Med 33(4):531–534. https://doi.org/10.1016/j.ajem.2015.01.025CrossRefPubMed

614.

Yang D, Kim KH, Oh JH, Son S, Cho J, Seo KM (2019) Development and evaluation of a new chest compression technique for cardiopulmonary resuscitation in infants. Pediatr Cardiol 40(6):1217–1223. https://doi.org/10.1007/s00246-019-02135-xCrossRefPubMed

615.

Ladny JR, Smereka J, Rodriguez-Nunez A, Leung S, Ruetzler K, Szarpak L (2018) Is there any alternative to standard chest compression techniques in infants? A randomized manikin trial of the new “2-thumb-fist” option. Medicine 97(5):e9386. https://doi.org/10.1097/MD.0000000000009386CrossRefPubMedPubMedCentral

616.

Rodriguez-Ruiz E, Martinez-Puga A, Carballo-Fazanes A, Abelairas-Gomez C, Rodriguez-Nunez A (2019) Two new chest compression methods might challenge the standard in a simulated infant model. Eur J Pediatr 178(10):1529–1535. https://doi.org/10.1007/s00431-019-03452-2CrossRefPubMed

617.

Rodriguez-Ruiz E, Guerra MV, Abelairas-Gomez C et al (2019) A new chest compression technique in infants. Med Intensiva 43(6):346–351. https://doi.org/10.1016/j.medin.2018.04.010CrossRefPubMed

618.

Jo CH, Cho GC, Lee CH (2017) Two-thumb encircling technique over the head of patients in the setting of lone rescuer infant CPR occurred during ambulance transfer: a crossover simulation study. Pediatr Emerg Care 33(7):462–466. https://doi.org/10.1097/PEC.0000000000000833CrossRefPubMed

619.

Na JU, Choi PC, Lee HJ, Shin DH, Han SK, Cho JH (2015) A vertical two-thumb technique is superior to the two-thumb encircling technique for infant cardiopulmonary resuscitation. Acta Paediatr 104(2):e70–e75. https://doi.org/10.1111/apa.12857CrossRefPubMed

620.

Pellegrino JL, Bogumil D, Epstein JL, Burke RV (2019) Two-thumb-encircling advantageous for lay responder infant CPR: a randomised manikin study. Arch Dis Child 104(6):530–534. https://doi.org/10.1136/archdischild-2018-314893CrossRefPubMed

621.

Tsou JY, Kao CL, Chang CJ, Tu YF, Su FC, Chi CH (2020) Biomechanics of two-thumb versus two-finger chest compression for cardiopulmonary resuscitation in an infant manikin model. Eur J Emerg Med 27(2):132–136. https://doi.org/10.1097/MEJ.0000000000000631CrossRefPubMed

622.

Kim YS, Oh JH, Kim CW, Kim SE, Lee DH, Hong JY (2016) Which fingers should we perform two-finger chest compression technique with when performing cardiopulmonary resuscitation on an infant in cardiac arrest? J Korean Med Sci 31(6):997–1002. https://doi.org/10.3346/jkms.2016.31.6.997CrossRefPubMedPubMedCentral

623.

Nasiri E, Nasiri R (2014) A comparison between over-the-head and lateral cardiopulmonary resuscitation with a single rescuer by bag-valve mask. Saudi J Anaesth 8(1):30–37. https://doi.org/10.4103/1658-354X.125923CrossRefPubMedPubMedCentral

624.

Cheong SA, Oh JH, Kim CW, Kim SE, Lee DH (2015) Effects of alternating hands during in-hospital one-handed chest compression: a randomised cross-over manikin trial. Emerg Med Australas 27(6):567–572. https://doi.org/10.1111/1742-6723.12492CrossRefPubMed

625.

Oh JH, Kim CW, Kim SE, Lee DH, Lee SJ (2015) One-handed chest compression technique for paediatric cardiopulmonary resuscitation: dominant versus non-dominant hand. Emerg Med Clin North Am 32(7):544–546. https://doi.org/10.1136/emermed-2014-203932CrossRef

626.

Lee SY, Hong JY, Oh JH, Son SH (2018) The superiority of the two-thumb over the two-finger technique for single-rescuer infant cardiopulmonary resuscitation. Eur J Emerg Med 25(5):372–376. https://doi.org/10.1097/MEJ.0000000000000461CrossRefPubMed

627.

Lee SS, Lee SD, Oh JH (2019) Comparison between modified and conventional one-handed chest compression techniques for child cardiopulmonary resuscitation: A randomised, non-blind, cross-over simulation trial. J Paediatr Child Health 55(11):1361–1366. https://doi.org/10.1111/jpc.14422CrossRefPubMed

628.

Kherbeche H, Exer N, Schuhwerk W, Ummenhofer W, Osterwalder J (2017) Chest compression using the foot or hand method: a prospective, randomized, controlled manikin study with school children. Eur J Emerg Med 24(4):262–267. https://doi.org/10.1097/MEJ.0000000000000335CrossRefPubMed

629.

Smereka J, Szarpak L, Ladny JR, Rodriguez-Nunez A, Ruetzler K (2018) A novel method of newborn chest compression: a randomized crossover simulation study. Front Pediatr 6:159. https://doi.org/10.3389/fped.2018.00159CrossRefPubMedPubMedCentral

630.

Park JW, Jung JY, Kim J et al (2019) A novel infant chest compression assist device using a palm rather than fingers: a randomized crossover trial. Prehosp Emerg Care 23(1):74–82. https://doi.org/10.1080/10903127.2018.1471559CrossRefPubMed

631.

Jung WJ, Hwang SO, Kim HI et al (2019) ‘Knocking-fingers’ chest compression technique in infant cardiac arrest: single-rescuer manikin study. Eur J Emerg Med 26(4):261–265. https://doi.org/10.1097/MEJ.0000000000000539CrossRefPubMed

632.

Smereka J, Szarpak L, Rodriguez-Nunez A, Ladny JR, Leung S, Ruetzler K (2017) A randomized comparison of three chest compression techniques and associated hemodynamic effect during infant CPR: a randomized manikin study. Am J Emerg Med 35(10):1420–1425. https://doi.org/10.1016/j.ajem.2017.04.024CrossRefPubMed

633.

Lopez-Herce J, Almonte E, Alvarado M et al (2018) Latin American consensus for pediatric cardiopulmonary resuscitation 2017: latin American pediatric critical care society pediatric cardiopulmonary resuscitation committee. Pediatr Crit Care Med 19(3):e152–e156. https://doi.org/10.1097/PCC.0000000000001427CrossRefPubMed

634.

Rossano JW, Jones WE, Lerakis S et al (2015) The use of automated external defibrillators in infants: a report from the American red cross scientific advisory council. Pediatr Emerg Care 31(7):526–530. https://doi.org/10.1097/PEC.0000000000000490CrossRefPubMed

635.

Hoyt WJ Jr., Fish FA, Kannankeril PJ (2019) Automated external defibrillator use in a previously healthy 31-day-old infant with out-of-hospital cardiac arrest due to ventricular fibrillation. J Cardiovasc Electrophysiol 30(11):2599–2602. https://doi.org/10.1111/jce.14125CrossRefPubMed

636.

Johnson MA, Grahan BJ, Haukoos JS et al (2014) Demographics, bystander CPR, and AED use in out-of-hospital pediatric arrests. Resuscitation 85(7):920–926. https://doi.org/10.1016/j.resuscitation.2014.03.044CrossRefPubMedPubMedCentral

637.

Mitani Y, Ohta K, Yodoya N et al (2013) Public access defibrillation improved the outcome after out-of-hospital cardiac arrest in school-age children: a nationwide, population-based, Utstein registry study in Japan. Europace 15(9):1259–1266. https://doi.org/10.1093/europace/eut053CrossRefPubMedPubMedCentral

638.

Swor R, Grace H, McGovern H, Weiner M, Walton E (2013) Cardiac arrests in schools: assessing use of automated external defibrillators (AED) on school campuses. Resuscitation 84(4):426–429. https://doi.org/10.1016/j.resuscitation.2012.09.014CrossRefPubMed

639.

Nagata T, Abe T, Noda E, Hasegawa M, Hashizume M, Hagihara A (2014) Factors associated with the clinical outcomes of paediatric out-of-hospital cardiac arrest in Japan. Bmj Open 4(2):e3481. https://doi.org/10.1136/bmjopen-2013-003481CrossRefPubMedPubMedCentral

640.

Hunt EA, Duval-Arnould JM, Bembea MM et al (2018) Association between time to Defibrillation and survival in pediatric in-hospital cardiac arrest with a first documented Shockable rhythm. JAMA Netw Open 1(5):e182643. https://doi.org/10.1001/jamanetworkopen.2018.2643CrossRefPubMedPubMedCentral

641.

Tsuda T, Geary EM, Temple J (2019) Significance of automated external defibrillator in identifying lethal ventricular arrhythmias. Eur J Pediatr 178(9):1333–1342. https://doi.org/10.1007/s00431-019-03421-9CrossRefPubMed

642.

El-Assaad I, Al-Kindi SG, McNally B et al (2018) Automated external defibrillator application before EMS arrival in pediatric cardiac arrests. Pediatrics. https://doi.org/10.1542/peds.2017-1903CrossRefPubMed

643.

Goto Y, Funada A, Goto Y (2016) Subsequent Shockable rhythm during out-of-hospital cardiac arrest in children with initial non-Shockable rhythms: a nationwide population-based observational study. JAHA. https://doi.org/10.1161/JAHA.116.003589CrossRefPubMedPubMedCentral

644.

Pundi KN, Bos JM, Cannon BC, Ackerman MJ (2015) Automated external defibrillator rescues among children with diagnosed and treated long QT syndrome. Heart Rhythm 12(4):776–781. https://doi.org/10.1016/j.hrthm.2015.01.002CrossRefPubMed

645.

Griffis H, Wu L, Naim MY et al (2020) Characteristics and outcomes of AED use in pediatric cardiac arrest in public settings: the influence of neighborhood characteristics. Resuscitation 146:126–131. https://doi.org/10.1016/j.resuscitation.2019.09.038CrossRefPubMed

646.

Rehn M, Hyldmo PK, Magnusson V et al (2016) Scandinavian SSAI clinical practice guideline on pre-hospital airway management. Acta Anaesthesiol Scand 60(7):852–864. https://doi.org/10.1111/aas.12746CrossRefPubMedPubMedCentral

647.

Borra V, Avau B, De Paepe P, Vandekerckhove P, De Buck E (2019) Is placing a victim in the left lateral decubitus position an effective first aid intervention for acute oral poisoning? A systematic review. Clin Toxicol 57(7):603–616. https://doi.org/10.1080/15563650.2019.1574975CrossRef

648.

Hyldmo PK, Vist GE, Feyling AC et al (2015) Is the supine position associated with loss of airway patency in unconscious trauma patients? A systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med 23:50. https://doi.org/10.1186/s13049-015-0116-0CrossRefPubMedPubMedCentral

649.

Hyldmo PK, Vist GE, Feyling AC et al (2015) Does turning trauma patients with an unstable spinal injury from the supine to a lateral position increase the risk of neurological deterioration?—A systematic review. Scand J Trauma Resusc Emerg Med 23:65. https://doi.org/10.1186/s13049-015-0143-xCrossRefPubMedPubMedCentral

650.

Freire-Tellado M, Navarro-Paton R, Pavon-Prieto MDP, Fernandez-Lopez M, Mateos-Lorenzo J, Lopez-Forneas I (2017) Does lying in the recovery position increase the likelihood of not delivering cardiopulmonary resuscitation? Resuscitation 115:173–177. https://doi.org/10.1016/j.resuscitation.2017.03.008CrossRefPubMed

651.

Navarro-Paton R, Freire-Tellado M, Fernandez-Gonzalez N, Basanta-Camino S, Mateos-Lorenzo J, Lago-Ballesteros J (2019) What is the best position to place and re-evaluate an unconscious but normally breathing victim? A randomised controlled human simulation trial on children. Resuscitation 134:104–109. https://doi.org/10.1016/j.resuscitation.2018.10.030CrossRefPubMed

652.

Fukushima H, Imanishi M, Iwami T et al (2015) Abnormal breathing of sudden cardiac arrest victims described by laypersons and its association with emergency medical service dispatcher-assisted cardiopulmonary resuscitation instruction. Emerg Med Clin North Am 32(4):314–317. https://doi.org/10.1136/emermed-2013-203112CrossRef

653.

Hyldmo PK, Horodyski M, Conrad BP et al (2017) Does the novel lateral trauma position cause more motion in an unstable cervical spine injury than the logroll maneuver? Am J Emerg Med 35(11):1630–1635. https://doi.org/10.1016/j.ajem.2017.05.002CrossRefPubMed

654.

Hyldmo PK, Horodyski MB, Conrad BP et al (2016) Safety of the lateral trauma position in cervical spine injuries: a cadaver model study. Acta Anaesthesiol Scand 60(7):1003–1011. https://doi.org/10.1111/aas.12714CrossRefPubMedPubMedCentral

655.

Julliand S, Desmarest M, Gonzalez L et al (2016) Recovery position significantly associated with a reduced admission rate of children with loss of consciousness. Arch Dis Child 101(6):521–526. https://doi.org/10.1136/archdischild-2015-308857CrossRefPubMed

656.

Del Rossi G, Dubose D, Scott N et al (2014) Motion produced in the unstable cervical spine by the HAINES and lateral recovery positions. Prehosp Emerg Care 18(4):539–543. https://doi.org/10.3109/10903127.2014.916019CrossRefPubMed

657.

Cheng J, Liu B, Farjat AE, Routh J (2019) National estimations of airway foreign bodies in children in the United States, 2000 to 2009. Clin Otolaryngol 44(3):235–239. https://doi.org/10.1111/coa.13261CrossRefPubMed

658.

Redding JS (1979) The choking controversy: critique of evidence on the Heimlich maneuver. Crit Care Med 7(10):475–479 (https://www.ncbi.nlm.nih.gov/pubmed/477356)CrossRefPubMed

659.

Langhelle A, Sunde K, Wik L, Steen PA (2000) Airway pressure with chest compressions versus Heimlich manoeuvre in recently dead adults with complete airway obstruction. Resuscitation 44(2):105–108CrossRefPubMed

660.

Vilke GM, Smith AM, Ray LU, Steen PJ, Murrin PA, Chan TC (2004) Airway obstruction in children aged less than 5 years: the prehospital experience. Prehosp Emerg Care 8(2):196–199PubMed

661.

Heimlich HJ, Patrick EA (1990) The Heimlich maneuver. Best technique for saving any choking victim’s life. Postgrad Med 87(6):38–48, 53. https://doi.org/10.1080/00325481.1990.11716329CrossRefPubMed

662.

Chillag S, Krieg J, Bhargava R (2010) The Heimlich maneuver: breaking down the complications. South Med J 103(2):147–150. https://doi.org/10.1097/SMJ.0b013e3181c99140CrossRefPubMed

663.

Dunne CL, Peden AE, Queiroga AC, Gomez Gonzalez C, Valesco B, Szpilman D (2020) A systematic review on the effectiveness of anti-choking suction devices and identification of research gaps. Resuscitation 153:219–226. https://doi.org/10.1016/j.resuscitation.2020.02.021CrossRefPubMed

664.

Kleinman ME, Chameides L, Schexnayder SM et al (2010) Part 14: pediatric advanced life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 122(18 Suppl 3):S876–S908. https://doi.org/10.1161/CIRCULATIONAHA.110.971101CrossRefPubMed

665.

de Caen AR, Maconochie IK, Aickin R et al (2015) Part 6: pediatric basic life support and pediatric advanced life support: 2015 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation 132(16 Suppl 1):S177–S203. https://doi.org/10.1161/CIR.0000000000000275CrossRefPubMed

666.

Maconochie IK, Bingham R, Eich C et al (2015) European resuscitation council guidelines for resuscitation 2015: section 6. Paediatric life support. Resuscitation 95:223–248. https://doi.org/10.1016/j.resuscitation.2015.07.028CrossRefPubMed

667.

Nadkarni VM, Larkin GL, Peberdy MA et al (2006) First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults. JAMA 295(1):50–57CrossRefPubMed

668.

Gilhooley C, Burnhill G, Gardiner D, Vyas H, Davies P (2019) Oxygen saturation and haemodynamic changes prior to circulatory arrest: implications for transplantation and resuscitation. J Intensive Care Soc 20(1):27–33. https://doi.org/10.1177/1751143718764541CrossRefPubMed

669.

Morgan RW, Reeder RW, Meert KL et al (2020) Survival and hemodynamics during pediatric cardiopulmonary resuscitation for Bradycardia and poor perfusion versus pulseless cardiac arrest. Crit Care Med 48(6):881–889. https://doi.org/10.1097/CCM.0000000000004308CrossRefPubMedPubMedCentral

670.

Khera R, Tang Y, Girotra S et al (2019) Pulselessness after initiation of cardiopulmonary resuscitation for Bradycardia in hospitalized children. Circulation 140(5):370–378. https://doi.org/10.1161/CIRCULATIONAHA.118.039048CrossRefPubMedPubMedCentral

671.

Fraser J, Sidebotham P, Frederick J, Covington T, Mitchell EA (2014) Learning from child death review in the USA, England, Australia, and New Zealand. Lancet 384(9946):894–903. https://doi.org/10.1016/S0140-6736(13)61089-2CrossRefPubMed

672.

Bhalala US, Balakumar N, Zamora M, Appachi E (2018) Hands-on defibrillation skills of pediatric acute care providers during a simulated ventricular fibrillation cardiac arrest scenario. Front Pediatr 6:107. https://doi.org/10.3389/fped.2018.00107CrossRefPubMedPubMedCentral

673.

Tibballs J, Carter B, Kiraly NJ, Ragg P, Clifford M (2011) External and internal biphasic direct current shock doses for pediatric ventricular fibrillation and pulseless ventricular tachycardia. Pediatr Crit Care Med 12(1):14–20. https://doi.org/10.1097/PCC.0b013e3181dbb4fcCrossRefPubMed

674.

Ristagno G, Yu T, Quan W, Freeman G, Li Y (2012) Comparison of defibrillation efficacy between two pads placements in a pediatric porcine model of cardiac arrest. Resuscitation 83(6):755–759. https://doi.org/10.1016/j.resuscitation.2011.12.010CrossRefPubMed

675.

Weisfeldt ML (2004) A three phase temporal model for cardiopulmonary resuscitation following cardiac arrest. Trans Am Clin Climatol Assoc 115:115–122 (discussion 122)PubMedPubMedCentral

676.

Society of Thoracic Surgeons Task Force on Resuscitation After Cardiac S (2017) The society of thoracic surgeons expert consensus for the resuscitation of patients who arrest after cardiac surgery. Ann Thorac Surg 103(3):1005–1020. https://doi.org/10.1016/j.athoracsur.2016.10.033CrossRef

677.

Soar J, Carli P, Couper K, Deakin CD, Djarv T, Lott C, Olasveengen T, Paal P, Pellis T, Perkins GD, Sandroni C, Nolan JP (2021) European resuscitation council guidelines 2021: advanced life support. Resuscitation 161:115–151. https://doi.org/10.1016/j.resuscitation.2021.02.010CrossRefPubMed

678.

Fukuda T, Ohashi-Fukuda N, Kobayashi H et al (2017) Public access defibrillation and outcomes after pediatric out-of-hospital cardiac arrest. Resuscitation 111:1–7. https://doi.org/10.1016/j.resuscitation.2016.11.010CrossRefPubMed

679.

Mercier E, Laroche E, Beck B et al (2019) Defibrillation energy dose during pediatric cardiac arrest: Systematic review of human and animal model studies. Resuscitation 139:241–252. https://doi.org/10.1016/j.resuscitation.2019.04.028CrossRefPubMed

680.

Hoyme DB, Zhou Y, Girotra S et al (2020) Improved survival to hospital discharge in pediatric in-hospital cardiac arrest using 2Joules/kilogram as first defibrillation dose for initial pulseless ventricular arrhythmia. Resuscitation 153:88–96. https://doi.org/10.1016/j.resuscitation.2020.05.048CrossRefPubMed

681.

Deakin CD, Morley P, Soar J, Drennan IR (2020) Double (dual) sequential defibrillation for refractory ventricular fibrillation cardiac arrest: a systematic review. Resuscitation 155:24–31. https://doi.org/10.1016/j.resuscitation.2020.06.008CrossRefPubMed

682.

Huang Y, He Q, Yang LJ, Liu GJ, Jones A (2014) Cardiopulmonary resuscitation (CPR) plus delayed defibrillation versus immediate defibrillation for out-of-hospital cardiac arrest. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD009803.pub2CrossRefPubMedPubMedCentral

683.

Bradley SM, Liu W, Chan PS et al (2016) Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry. BMJ 353:i1653. https://doi.org/10.1136/bmj.i1653CrossRefPubMedPubMedCentral

684.

Roh YI, Jung WJ, Hwang SO et al (2019) Shorter defibrillation interval promotes successful defibrillation and resuscitation outcomes. Resuscitation 143:100–105. https://doi.org/10.1016/j.resuscitation.2019.08.022CrossRefPubMed

685.

Brugger H, Durrer B, Elsensohn F et al (2013) Resuscitation of avalanche victims: Evidence-based guidelines of the international commission for mountain emergency medicine (ICAR MEDCOM): intended for physicians and other advanced life support personnel. Resuscitation 84(5):539–546. https://doi.org/10.1016/j.resuscitation.2012.10.020 (Practice Guideline Review)CrossRefPubMed

686.

Saczkowski RS, Brown DJA, Abu-Laban RB, Fradet G, Schulze CJ, Kuzak ND (2018) Prediction and risk stratification of survival in accidental hypothermia requiring extracorporeal life support: an individual patient data meta-analysis. Resuscitation 127:51–57. https://doi.org/10.1016/j.resuscitation.2018.03.028CrossRefPubMed

687.

Bauman BD, Louiselle A, Nygaard RM et al (2019) Treatment of hypothermic cardiac arrest in the pediatric drowning victim, a case report, and systematic review. Pediatr Emerg Care. https://doi.org/10.1097/PEC.0000000000001735CrossRefPubMed

688.

Sepehripour AH, Gupta S, Lall KS (2013) When should cardiopulmonary bypass be used in the setting of severe hypothermic cardiac arrest? Interact CardioVasc Thorac Surg 17(3):564–569. https://doi.org/10.1093/icvts/ivt208CrossRefPubMedPubMedCentral

689.

Dunne B, Christou E, Duff O, Merry C (2014) Extracorporeal-assisted rewarming in the management of accidental deep hypothermic cardiac arrest: a systematic review of the literature. Heart Lung Circ 23(11):1029–1035. https://doi.org/10.1016/j.hlc.2014.06.011CrossRefPubMed

690.

Paal P, Gordon L, Strapazzon G et al (2016) Accidental hypothermia-an update : the content of this review is endorsed by the international commission for mountain emergency medicine (ICAR MEDCOM). Scand J Trauma Resusc Emerg Med 24(1):111. https://doi.org/10.1186/s13049-016-0303-7CrossRefPubMedPubMedCentral

691.

Best RR, Harris BHL, Walsh JL, Manfield T (2020) Pediatric drowning: a standard operating procedure to aid the prehospital management of pediatric cardiac arrest resulting from submersion. Pediatr Emerg Care 36(3):143–146. https://doi.org/10.1097/PEC.0000000000001169CrossRefPubMed

692.

Strapazzon G, Plankensteiner J, Mair P et al (2017) Prehospital management and outcome of avalanche patients with out-of-hospital cardiac arrest: a retrospective study in Tyrol, Austria. Eur J Emerg Med 24(6):398–403. https://doi.org/10.1097/MEJ.0000000000000390CrossRefPubMed

693.

Svendsen OS, Grong K, Andersen KS, Husby P (2017) Outcome after rewarming from accidental hypothermia by use of extracorporeal circulation. Ann Thorac Surg 103(3):920–925. https://doi.org/10.1016/j.athoracsur.2016.06.093CrossRefPubMed

694.

Mentzelopoulos SD, Couper K, Van de Voorde P et al. (2021) Ethik der Reanimation und Entscheidungen am Lebensende. Leitlinien des European Resuscitation Council 2021. Notfall Rettungsmed. https://doi.org/10.1007/s10049-021-00888-8CrossRef

695.

Patel JK, Kataya A, Parikh PB (2018) Association between intra- and post-arrest hyperoxia on mortality in adults with cardiac arrest: a systematic review and meta-analysis. Resuscitation 127:83–88. https://doi.org/10.1016/j.resuscitation.2018.04.008CrossRefPubMed

696.

Soar J, Maconochie I, Wyckoff MH et al (2019) 2019 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation 145:95–150. https://doi.org/10.1016/j.resuscitation.2019.10.016CrossRefPubMed

697.

Okubo M, Komukai S, Izawa J et al (2019) Prehospital advanced airway management for paediatric patients with out-of-hospital cardiac arrest: a nationwide cohort study. Resuscitation 145:175–184. https://doi.org/10.1016/j.resuscitation.2019.09.007CrossRefPubMed

698.

Fukuda T, Sekiguchi H, Taira T et al (2020) Type of advanced airway and survival after pediatric out-of-hospital cardiac arrest. Resuscitation 150:145–153. https://doi.org/10.1016/j.resuscitation.2020.02.005CrossRefPubMed

699.

Lopez J, Fernandez SN, Gonzalez R, Solana MJ, Urbano J, Lopez-Herce J (2016) Different respiratory rates during resuscitation in a pediatric animal model of Asphyxial cardiac arrest. Plos One 11(9):e162185. https://doi.org/10.1371/journal.pone.0162185CrossRefPubMedPubMedCentral

700.

Gonzalez R, Pascual L, Sava A, Tolon S, Urbano J, Lopez-Herce J (2017) Ventilation during cardiopulmonary resuscitation in children: a survey on clinical practice. World J Pediatr 13(6):544–550. https://doi.org/10.1007/s12519-017-0061-2CrossRefPubMed

701.

Aufderheide TP, Sigurdsson G, Pirrallo RG et al (2004) Hyperventilation-induced hypotension during cardiopulmonary resuscitation. Circulation 109(16):1960–1965 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15066941)CrossRefPubMed

702.

Yannopoulos D, Tang W, Roussos C, Aufderheide TP, Idris AH, Lurie KG (2005) Reducing ventilation frequency during cardiopulmonary resuscitation in a porcine model of cardiac arrest. Respir Care 50(5):628–635 (In eng)PubMed

703.

Lapid FM, O’Brien CE, Kudchadkar SR et al (2020) The use of pressure-controlled mechanical ventilation in a swine model of intraoperative pediatric cardiac arrest. Paediatr Anaesth 30(4):462–468. https://doi.org/10.1111/pan.13820CrossRefPubMedPubMedCentral

704.

Kjaergaard B, Bavarskis E, Magnusdottir SO et al (2016) Four ways to ventilate during cardiopulmonary resuscitation in a porcine model: a randomized study. Scand J Trauma Resusc Emerg Med 24:67. https://doi.org/10.1186/s13049-016-0262-zCrossRefPubMedPubMedCentral

705.

Tan D, Xu J, Shao S et al (2017) Comparison of different inspiratory triggering settings in automated ventilators during cardiopulmonary resuscitation in a porcine model. Plos One 12(2):e171869. https://doi.org/10.1371/journal.pone.0171869CrossRefPubMedPubMedCentral

706.

Kill C, Hahn O, Dietz F et al (2014) Mechanical ventilation during cardiopulmonary resuscitation with intermittent positive-pressure ventilation, bilevel ventilation, or chest compression synchronized ventilation in a pig model. Crit Care Med 42(2):e89–e95. https://doi.org/10.1097/CCM.0b013e3182a63fa0CrossRefPubMed

707.

Kill C, Galbas M, Neuhaus C et al (2015) Chest compression synchronized ventilation versus intermitted positive pressure ventilation during cardiopulmonary resuscitation in a pig model. Plos One 10(5):e127759. https://doi.org/10.1371/journal.pone.0127759CrossRefPubMedPubMedCentral

708.

Schaller SJ, Altmann S, Unsworth A et al (2019) Continuous chest compressions with a simultaneous triggered ventilator in the Munich Emergency Medical Services: a case series. Ger Med Sci 17:Doc6. https://doi.org/10.3205/000272CrossRefPubMedPubMedCentral

709.

Mendler MR, Maurer M, Hassan MA et al (2015) Different techniques of respiratory support do not significantly affect gas exchange during cardiopulmonary resuscitation in a newborn piglet model. Neonatology 108(1):73–80. https://doi.org/10.1159/000381416CrossRefPubMed

710.

Mendler MR, Weber C, Hassan MA, Huang L, Mayer B, Hummler HD (2017) Tidal Volume Delivery and Endotracheal Tube Leak during Cardiopulmonary Resuscitation in Intubated Newborn Piglets with Hypoxic Cardiac Arrest Exposed to Different Modes of Ventilatory Support. Neonatology 111(2):100–106. https://doi.org/10.1159/000447663CrossRefPubMed

711.

Salas N, Wisor B, Agazio J, Branson R, Austin PN (2007) Comparison of ventilation and cardiac compressions using the Impact Model 730 automatic transport ventilator compared to a conventional bag valve with a facemask in a model of adult cardiopulmonary arrest. Resuscitation 74(1):94–101. https://doi.org/10.1016/j.resuscitation.2006.01.023CrossRefPubMed

712.

Hurst VT, West S, Austin P, Branson R, Beck G (2007) Comparison of ventilation and chest compression performance by bystanders using the Impact Model 730 ventilator and a conventional bag valve with mask in a model of adult cardiopulmonary arrest. Resuscitation 73(1):123–130. https://doi.org/10.1016/j.resuscitation.2006.07.027CrossRefPubMed

713.

Allen SG, Brewer L, Gillis ES, Pace NL, Sakata DJ, Orr JA (2017) A turbine-driven ventilator improves adherence to advanced cardiac life support guidelines during a cardiopulmonary resuscitation simulation. Respir Care 62(9):1166–1170. https://doi.org/10.4187/respcare.05368CrossRefPubMed

714.

Grieco DL, Brochard LJ, Drouet A et al (2019) Intrathoracic airway closure impacts CO2 signal and delivered ventilation during cardiopulmonary resuscitation. Am J Respir Crit Care Med 199(6):728–737. https://doi.org/10.1164/rccm.201806-1111OCCrossRefPubMed

715.

Holmberg MJ, Nicholson T, Nolan JP et al (2020) Oxygenation and ventilation targets after cardiac arrest: a systematic review and meta-analysis. Resuscitation 152:107–115. https://doi.org/10.1016/j.resuscitation.2020.04.031CrossRefPubMed

716.

Andersen LW, Berg KM, Saindon BZ et al (2015) Time to epinephrine and survival after pediatric in-hospital cardiac arrest. JAMA 314(8):802–810. https://doi.org/10.1001/jama.2015.9678CrossRefPubMedPubMedCentral

717.

Meert K, Telford R, Holubkov R et al (2018) Paediatric in-hospital cardiac arrest: factors associated with survival and neurobehavioural outcome one year later. Resuscitation 124:96–105. https://doi.org/10.1016/j.resuscitation.2018.01.013CrossRefPubMedPubMedCentral

718.

Hoyme DB, Patel SS, Samson RA et al (2017) Epinephrine dosing interval and survival outcomes during pediatric in-hospital cardiac arrest. Resuscitation 117:18–23. https://doi.org/10.1016/j.resuscitation.2017.05.023CrossRefPubMed

719.

Raymond TT, Praestgaard A, Berg RA, Nadkarni VM, Parshuram CS, American Heart Association (2019) The Association of Hospital Rate of Delayed Epinephrine Administration With Survival to Discharge for Pediatric Nonshockable In-Hospital Cardiac Arrest. Pediatr Crit Care Med 20(5):405–416. https://doi.org/10.1097/PCC.0000000000001863CrossRefPubMed

720.

Bellamy D, Nuthall G, Dalziel S, Skinner JR (2019) Catecholaminergic polymorphic ventricular tachycardia: the cardiac arrest where epinephrine is contraindicated. Pediatr Crit Care Med 20(3):262–268. https://doi.org/10.1097/PCC.0000000000001847CrossRefPubMedPubMedCentral

721.

Lin YR, Li CJ, Huang CC et al (2019) Early epinephrine improves the stabilization of initial post-resuscitation Hemodynamics in children with non-shockable out-of-hospital cardiac arrest. Front Pediatr 7:220. https://doi.org/10.3389/fped.2019.00220CrossRefPubMedPubMedCentral

722.

Lin YR, Wu MH, Chen TY et al (2019) Time to epinephrine treatment is associated with the risk of mortality in children who achieve sustained ROSC after traumatic out-of-hospital cardiac arrest. Crit Care 23(1):101. https://doi.org/10.1186/s13054-019-2391-zCrossRefPubMedPubMedCentral

723.

Hansen M, Schmicker RH, Newgard CD et al (2018) Time to epinephrine administration and survival from nonshockable out-of-hospital cardiac arrest among children and adults. Circulation 137(19):2032–2040. https://doi.org/10.1161/CIRCULATIONAHA.117.033067CrossRefPubMedPubMedCentral

724.

Fukuda T, Kondo Y, Hayashida K, Sekiguchi H, Kukita I (2018) Time to epinephrine and survival after paediatric out-of-hospital cardiac arrest. Eur Heart J Cardiovasc Pharmacother 4(3):144–151. https://doi.org/10.1093/ehjcvp/pvx023CrossRefPubMed

725.

Lin YR, Syue YJ, Buddhakosai W et al (2016) Impact of different initial epinephrine treatment time points on the early postresuscitative hemodynamic status of children with traumatic out-of-hospital cardiac arrest. Medicine 95(12):e3195. https://doi.org/10.1097/MD.0000000000003195CrossRefPubMedPubMedCentral

726.

Wall JJ, Iyer RV (2017) Catecholaminergic polymorphic ventricular tachycardia. Pediatr Emerg Care 33(6):427–431. https://doi.org/10.1097/PEC.0000000000001156CrossRefPubMed

727.

Soar J, Perkins GD, Maconochie I et al (2019) European resuscitation council guidelines for resuscitation: 2018 update—antiarrhythmic drugs for cardiac arrest. Resuscitation 134:99–103. https://doi.org/10.1016/j.resuscitation.2018.11.018CrossRefPubMed

728.

Holmberg MJ, Ross CE, Atkins DL et al (2020) Lidocaine versus amiodarone for pediatric in-hospital cardiac arrest: an observational study. Resuscitation 149:191–201. https://doi.org/10.1016/j.resuscitation.2019.12.033CrossRefPubMed

729.

Mok YH, Loke AP, Loh TF, Lee JH (2016) Characteristics and risk factors for mortality in paediatric in-hospital cardiac events in Singapore: retrospective single centre experience. Ann Acad Med Singap 45(12):534–541 (https://www.ncbi.nlm.nih.gov/pubmed/28062881)PubMed

730.

Lasa JJ, Alali A, Minard CG et al (2019) Cardiopulmonary resuscitation in the pediatric cardiac catheterization laboratory: a report from the American Heart Association’s get with the guidelines-resuscitation registry. Pediatr Crit Care Med 20(11):1040–1047. https://doi.org/10.1097/PCC.0000000000002038CrossRefPubMed

731.

Writer H (2010) Cardiorespiratory arrest in children (out of hospital). BMJ Clin Evid 2010:0307. https://www.ncbi.nlm.nih.gov/pubmed/21406131PubMedPubMedCentral

732.

Wu ET, Li MJ, Huang SC et al (2009) Survey of outcome of CPR in pediatric in-hospital cardiac arrest in a medical center in Taiwan. Resuscitation 80(4):443–448. https://doi.org/10.1016/j.resuscitation.2009.01.006 (In eng)CrossRefPubMed

733.

Del Castillo J, Lopez-Herce J, Canadas S et al (2014) Cardiac arrest and resuscitation in the pediatric intensive care unit: a prospective multicenter multinational study. Resuscitation 85(10):1380–1386. https://doi.org/10.1016/j.resuscitation.2014.06.024CrossRefPubMed

734.

Wolfe HA, Sutton RM, Reeder RW et al (2019) Functional outcomes among survivors of pediatric in-hospital cardiac arrest are associated with baseline neurologic and functional status, but not with diastolic blood pressure during CPR. Resuscitation 143:57–65. https://doi.org/10.1016/j.resuscitation.2019.08.006CrossRefPubMedPubMedCentral

735.

Matamoros M, Rodriguez R, Callejas A et al (2015) In-hospital pediatric cardiac arrest in Honduras. Pediatr Emerg Care 31(1):31–35. https://doi.org/10.1097/PEC.0000000000000323CrossRefPubMed

736.

Lopez-Herce J, del Castillo J, Canadas S, Rodriguez-Nunez A, Carrillo A, Spanish Study Group of Cardiopulmonary Arrest in C (2014) In-hospital pediatric cardiac arrest in Spain. Rev Esp Cardiol 67(3):189–195. https://doi.org/10.1016/j.rec.2013.07.017 (Engl)CrossRefPubMed

737.

Raymond TT, Stromberg D, Stigall W, Burton G, Zaritsky A, American Heart Association’s Get With The Guidelines-Resuscitation I (2015) Sodium bicarbonate use during in-hospital pediatric pulseless cardiac arrest—a report from the American Heart Association Get With The Guidelines((R))-Resuscitation. Resuscitation 89:106–113. https://doi.org/10.1016/j.resuscitation.2015.01.007CrossRefPubMedPubMedCentral

738.

Berg RA, Reeder RW, Meert KL et al (2018) End-tidal carbon dioxide during pediatric in-hospital cardiopulmonary resuscitation. Resuscitation 133:173–179. https://doi.org/10.1016/j.resuscitation.2018.08.013CrossRefPubMedPubMedCentral

739.

Stine CN, Koch J, Brown LS, Chalak L, Kapadia V, Wyckoff MH (2019) Quantitative end-tidal CO2 can predict increase in heart rate during infant cardiopulmonary resuscitation. Heliyon 5(6):e1871. https://doi.org/10.1016/j.heliyon.2019.e01871CrossRefPubMedPubMedCentral

740.

Yates AR, Sutton RM, Reeder RW et al (2019) Survival and cardiopulmonary resuscitation hemodynamics following cardiac arrest in children with surgical compared to medical heart disease. Pediatr Crit Care Med 20(12):1126–1136. https://doi.org/10.1097/PCC.0000000000002088CrossRefPubMedPubMedCentral

741.

Berg RA, Sutton RM, Reeder RW et al (2018) Association between diastolic blood pressure during pediatric in-hospital cardiopulmonary resuscitation and survival. Circulation 137(17):1784–1795. https://doi.org/10.1161/CIRCULATIONAHA.117.032270CrossRefPubMed

742.

Caglar A, Er A, Ulusoy E et al (2017) Cerebral oxygen saturation monitoring in pediatric cardiopulmonary resuscitation patients in the emergency settings: a small descriptive study. Turk J Pediatr 59(6):642–647. https://doi.org/10.24953/turkjped.2017.06.004CrossRefPubMed

743.

Abramo TJ, Meredith M, Jaeger M et al (2014) Cerebral oximetry with blood volume index in asystolic pediatric cerebrospinal fluid malfunctioning shunt patients. Am J Emerg Med 32(11):1439.e1‑7. https://doi.org/10.1016/j.ajem.2014.04.007CrossRefPubMed

744.

Pasquier M, Hugli O, Paal P et al (2018) Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: the HOPE score. Resuscitation 126:58–64. https://doi.org/10.1016/j.resuscitation.2018.02.026CrossRefPubMed

745.

Hilmo J, Naesheim T, Gilbert M (2014) “Nobody is dead until warm and dead”: prolonged resuscitation is warranted in arrested hypothermic victims also in remote areas—a retrospective study from northern Norway. Resuscitation 85(9):1204–1211. https://doi.org/10.1016/j.resuscitation.2014.04.029CrossRefPubMed

746.

Wollenek G, Honarwar N, Golej J, Marx M (2002) Cold water submersion and cardiac arrest in treatment of severe hypothermia with cardiopulmonary bypass. Resuscitation 52(3):255–263CrossRefPubMed

747.

Huang SC, Wu ET, Wang CC et al (2012) Eleven years of experience with extracorporeal cardiopulmonary resuscitation for paediatric patients with in-hospital cardiac arrest. Resuscitation 83(6):710–714. https://doi.org/10.1016/j.resuscitation.2012.01.031 ((Research Support, Non‑U.S. Gov’t) (In eng).)CrossRefPubMed

748.

De Mul A, Nguyen DA, Doell C, Perez MH, Cannizzaro V, Karam O (2019) Prognostic evaluation of mortality after pediatric resuscitation assisted by extracorporeal life support. J Pediatr Intensive Care 8(2):57–63. https://doi.org/10.1055/s-0038-1667012CrossRefPubMed

749.

Pasquier M, Rousson V (2020) Qualification for extracorporeal life support in accidental hypothermia: the HOPE score. Ann Thorac Surg. https://doi.org/10.1016/j.athoracsur.2020.06.146CrossRefPubMed

750.

Dunning J, Fabbri A, Kolh PH et al (2009) Guideline for resuscitation in cardiac arrest after cardiac surgery. Eur J Cardiothorac Surg 36(1):3–28. https://doi.org/10.1016/j.ejcts.2009.01.033 (In eng)CrossRefPubMed

751.

Tsou PY, Kurbedin J, Chen YS et al (2017) Accuracy of point-of-care focused echocardiography in predicting outcome of resuscitation in cardiac arrest patients: A systematic review and meta-analysis. Resuscitation 114:92–99. https://doi.org/10.1016/j.resuscitation.2017.02.021CrossRefPubMed

752.

Bhananker SM, Ramamoorthy C, Geiduschek JM et al (2007) Anesthesia-related cardiac arrest in children: update from the Pediatric Perioperative Cardiac Arrest Registry. Anesth Analg 105(2):344–350. https://doi.org/10.1213/01.ane.0000268712.00756.ddCrossRefPubMed

753.

Spyres MB, Farrugia LA, Kang AM et al (2019) The toxicology investigators consortium case registry-the 2018 annual report. J Med Toxicol 15(4):228–254. https://doi.org/10.1007/s13181-019-00736-9CrossRefPubMedPubMedCentral

754.

Larach MG, Rosenberg H, Gronert GA, Allen GC (1997) Hyperkalemic cardiac arrest during anesthesia in infants and children with occult myopathies. Clin Pediatr (Phila) 36(1):9–16. https://doi.org/10.1177/000992289703600102CrossRef

755.

Carreiro S, Miller S, Wang B, Wax P, Campleman S, Manini AF (2020) Clinical predictors of adverse cardiovascular events for acute pediatric drug exposures. Clin Toxicol 58(3):183–189. https://doi.org/10.1080/15563650.2019.1634272CrossRef

756.

Morgan RW, Fitzgerald JC, Weiss SL, Nadkarni VM, Sutton RM, Berg RA (2017) Sepsis-associated in-hospital cardiac arrest: epidemiology, pathophysiology, and potential therapies. J Crit Care 40:128–135. https://doi.org/10.1016/j.jcrc.2017.03.023CrossRefPubMed

757.

Workman JK, Bailly DK, Reeder RW et al (2020) Risk factors for mortality in refractory pediatric septic shock supported with extracorporeal life support. ASAIO J 66(10):1152–1160. https://doi.org/10.1097/MAT.0000000000001147CrossRefPubMedPubMedCentral

758.

Sole A, Jordan I, Bobillo S et al (2018) Venoarterial extracorporeal membrane oxygenation support for neonatal and pediatric refractory septic shock: more than 15 years of learning. Eur J Pediatr 177(8):1191–1200. https://doi.org/10.1007/s00431-018-3174-2CrossRefPubMed

759.

Torres-Andres F, Fink EL, Bell MJ, Sharma MS, Yablonsky EJ, Sanchez-de-Toledo J (2018) Survival and long-term functional outcomes for children with cardiac arrest treated with extracorporeal cardiopulmonary resuscitation. Pediatr Crit Care Med 19(5):451–458. https://doi.org/10.1097/PCC.0000000000001524CrossRefPubMedPubMedCentral

760.

Barbaro RP, Paden ML, Guner YS et al (2017) Pediatric extracorporeal life support organization registry international report 2016. ASAIO J 63(4):456–463. https://doi.org/10.1097/MAT.0000000000000603CrossRefPubMedPubMedCentral

761.

Shin HJ, Song S, Park HK, Park YH (2016) Results of extracorporeal cardiopulmonary resuscitation in children. Korean J Thorac Cardiovasc Surg 49(3):151–156. https://doi.org/10.5090/kjtcs.2016.49.3.151CrossRefPubMedPubMedCentral

762.

Oberender F, Ganeshalingham A, Fortenberry JD et al (2018) Venoarterial extracorporeal membrane oxygenation versus conventional therapy in severe pediatric septic shock. Pediatr Crit Care Med 19(10):965–972. https://doi.org/10.1097/PCC.0000000000001660CrossRefPubMed

763.

Weiss SL, Balamuth F, Hensley J et al (2017) The epidemiology of hospital death following pediatric severe sepsis: when, why, and how children with sepsis die. Pediatr Crit Care Med 18(9):823–830. https://doi.org/10.1097/PCC.0000000000001222CrossRefPubMedPubMedCentral

764.

Cunningham A, Auerbach M, Cicero M, Jafri M (2018) Tourniquet usage in prehospital care and resuscitation of pediatric trauma patients-Pediatric Trauma Society position statement. J Trauma Acute Care Surg 85(4):665–667. https://doi.org/10.1097/TA.0000000000001839CrossRefPubMed

765.

American College of Surgeons Committee on T, American College of Emergency Physicians Pediatric Emergency Medicine C, National Association of Ems P, American Academy of Pediatrics Committee on Pediatric Emergency M, Fallat ME (2014) Withholding or termination of resuscitation in pediatric out-of-hospital traumatic cardiopulmonary arrest. Pediatrics 133(4):e1104–e1116. https://doi.org/10.1542/peds.2014-0176CrossRef

766.

Zwingmann J, Mehlhorn AT, Hammer T, Bayer J, Sudkamp NP, Strohm PC (2012) Survival and neurologic outcome after traumatic out-of-hospital cardiopulmonary arrest in a pediatric and adult population: a systematic review. Crit Care 16(4):R117. https://doi.org/10.1186/cc11410CrossRefPubMedPubMedCentral

767.

Donoghue AJ, Nadkarni V, Berg RA et al (2005) Out-of-hospital pediatric cardiac arrest: an epidemiologic review and assessment of current knowledge. Ann Emerg Med 46(6):512–522CrossRefPubMed

768.

Alqudah Z, Nehme Z, Alrawashdeh A, Williams B, Oteir A, Smith K (2020) Paediatric traumatic out-of-hospital cardiac arrest: a systematic review and meta-analysis. Resuscitation 149:65–73. https://doi.org/10.1016/j.resuscitation.2020.01.037CrossRefPubMed

769.

Moore L, Champion H, Tardif PA et al (2018) Impact of trauma system structure on injury outcomes: a systematic review and meta-analysis. World J Surg 42(5):1327–1339. https://doi.org/10.1007/s00268-017-4292-0CrossRefPubMed

770.

Puzio T, Murphy P, Gazzetta J, Phillips M, Cotton BA, Hartwell JL (2019) Extracorporeal life support in pediatric trauma: a systematic review. Trauma Surg Acute Care Open 4(1):e362. https://doi.org/10.1136/tsaco-2019-000362CrossRefPubMedPubMedCentral

771.

Tan BK, Pothiawala S, Ong ME (2013) Emergency thoracotomy: a review of its role in severe chest trauma. Minerva Chir 68(3):241–250 (https://www.ncbi.nlm.nih.gov/pubmed/23774089)PubMed

772.

Allen CJ, Valle EJ, Thorson CM et al (2015) Pediatric emergency department thoracotomy: a large case series and systematic review. J Pediatr Surg 50(1):177–181. https://doi.org/10.1016/j.jpedsurg.2014.10.042CrossRefPubMed

773.

Moskowitz EE, Burlew CC, Kulungowski AM, Bensard DD (2018) Survival after emergency department thoracotomy in the pediatric trauma population: a review of published data. Pediatr Surg Int 34(8):857–860. https://doi.org/10.1007/s00383-018-4290-9CrossRefPubMed

774.

Bennett M, Kissoon N (2007) Is cardiopulmonary resuscitation warranted in children who suffer cardiac arrest post trauma? Pediatr Emerg Care 23(4):267–272. https://doi.org/10.1097/PEC.0b013e3180403088CrossRefPubMed

775.

Cameron A, Erdogan M, Lanteigne S, Hetherington A, Green RS (2018) Organ donation in trauma victims: a systematic review and meta-analysis. J Trauma Acute Care Surg 84(6):994–1002. https://doi.org/10.1097/TA.0000000000001886CrossRefPubMed

776.

Shibahashi K, Sugiyama K, Hamabe Y (2020) Pediatric out-of-hospital traumatic cardiopulmonary arrest after traffic accidents and termination of resuscitation. Ann Emerg Med 75(1):57–65. https://doi.org/10.1016/j.annemergmed.2019.05.036CrossRefPubMed

777.

Brindis SL, Gausche-Hill M, Young KD, Putnam B (2011) Universally poor outcomes of pediatric traumatic arrest: a prospective case series and review of the literature. Pediatr Emerg Care 27(7):616–621. https://doi.org/10.1097/PEC.0b013e31822255c9CrossRefPubMed

778.

Matos RI, Watson RS, Nadkarni VM et al (2013) Duration of cardiopulmonary resuscitation and illness category impact survival and neurologic outcomes for in-hospital pediatric cardiac arrests. Circulation 127(4):442–451. https://doi.org/10.1161/circulationaha.112.125625 (In eng)CrossRefPubMed

779.

Duron V, Burke RV, Bliss D, Ford HR, Upperman JS (2014) Survival of pediatric blunt trauma patients presenting with no signs of life in the field. J Trauma Acute Care Surg 77(3):422–426. https://doi.org/10.1097/TA.0000000000000394CrossRefPubMed

780.

Noje C, Bembea MM, McMillan NKL et al (2019) A national survey on Interhospital transport of children in cardiac arrest. Pediatr Crit Care Med 20(1):e30–e36. https://doi.org/10.1097/PCC.0000000000001768CrossRefPubMed

781.

Wieck MM, Cunningham AJ, Behrens B et al (2018) Direct to operating room trauma resuscitation decreases mortality among severely injured children. J Trauma Acute Care Surg 85(4):659–664. https://doi.org/10.1097/TA.0000000000001908CrossRefPubMed

782.

Michelson KA, Hudgins JD, Monuteaux MC, Bachur RG, Finkelstein JA (2018) Cardiac arrest survival in pediatric and general emergency departments. Pediatrics. https://doi.org/10.1542/peds.2017-2741CrossRefPubMed

783.

Moore HB, Moore EE, Bensard DD (2016) Pediatric emergency department thoracotomy: a 40-year review. J Pediatr Surg 51(2):315–318. https://doi.org/10.1016/j.jpedsurg.2015.10.040CrossRefPubMed

784.

Schauer SG, Hill GJ, Connor RE, Oh JS, April MD (2018) The pediatric resuscitative thoracotomy during combat operations in Iraq and Afghanistan—a retrospective cohort study. Injury 49(5):911–915. https://doi.org/10.1016/j.injury.2018.01.034CrossRefPubMed

785.

Flynn-O’Brien KT, Stewart BT, Fallat ME et al (2016) Mortality after emergency department thoracotomy for pediatric blunt trauma: analysis of the national trauma data bank 2007–2012. J Pediatr Surg 51(1):163–167. https://doi.org/10.1016/j.jpedsurg.2015.10.034CrossRefPubMed

786.

Capizzani AR, Drongowski R, Ehrlich PF (2010) Assessment of termination of trauma resuscitation guidelines: are children small adults? J Pediatr Surg 45(5):903–907. https://doi.org/10.1016/j.jpedsurg.2010.02.014CrossRefPubMed

787.

TraumaRegister DGU, Zwingmann J, Lefering R et al (2015) Outcome and risk factors in children after traumatic cardiac arrest and successful resuscitation. Resuscitation 96:59–65. https://doi.org/10.1016/j.resuscitation.2015.07.022CrossRef

788.

McLaughlin C, Zagory JA, Fenlon M et al (2018) Timing of mortality in pediatric trauma patients: a national trauma data bank analysis. J Pediatr Surg 53(2):344–351. https://doi.org/10.1016/j.jpedsurg.2017.10.006CrossRefPubMed

789.

Alqudah Z, Nehme Z, Williams B, Oteir A, Bernard S, Smith K (2019) A descriptive analysis of the epidemiology and management of paediatric traumatic out-of-hospital cardiac arrest. Resuscitation 140:127–134. https://doi.org/10.1016/j.resuscitation.2019.05.020CrossRefPubMed

790.

Kaestner M, Schranz D, Warnecke G, Apitz C, Hansmann G, Miera O (2016) Pulmonary hypertension in the intensive care unit. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart 102(Suppl 2):ii57–ii66. https://doi.org/10.1136/heartjnl-2015-307774CrossRefPubMed

791.

Marino BS, Tabbutt S, MacLaren G et al (2018) Cardiopulmonary resuscitation in infants and children with cardiac disease: a scientific statement from the American Heart Association. Circulation 137(22):e691–e782. https://doi.org/10.1161/CIR.0000000000000524CrossRefPubMed

792.

Morgan RW, Topjian AA, Wang Y et al (2020) Prevalence and outcomes of pediatric in-hospital cardiac arrest associated with pulmonary hypertension. Pediatr Crit Care Med 21(4):305–313. https://doi.org/10.1097/PCC.0000000000002187CrossRefPubMedPubMedCentral

793.

Loaec M, Himebauch AS, Kilbaugh TJ et al (2020) Pediatric cardiopulmonary resuscitation quality during intra-hospital transport. Resuscitation 152:123–130. https://doi.org/10.1016/j.resuscitation.2020.05.003CrossRefPubMedPubMedCentral

794.

Anton-Martin P, Moreira A, Kang P, Green ML (2020) Outcomes of paediatric cardiac patients after 30 minutes of cardiopulmonary resuscitation prior to extracorporeal support. Cardiol Young 30(5):607–616. https://doi.org/10.1017/S1047951120000591CrossRefPubMed

795.

Morell E, Rajagopal SK, Oishi P, Thiagarajan RR, Fineman JR, Steurer MA (2020) Extracorporeal membrane oxygenation in pediatric pulmonary hypertension. Pediatr Crit Care Med 21(3):256–266. https://doi.org/10.1097/PCC.0000000000002127CrossRefPubMed

796.

Melvan JN, Davis J, Heard M et al (2020) Factors associated with survival following extracorporeal cardiopulmonary resuscitation in children. World J Pediatr Congenit Heart Surg 11(3):265–274. https://doi.org/10.1177/2150135120902102CrossRefPubMed

797.

Esangbedo ID, Brunetti MA, Campbell FM, Lasa JJ (2020) Pediatric extracorporeal cardiopulmonary resuscitation: a systematic review. Pediatr Crit Care Med 21(10):e934–e943. https://doi.org/10.1097/PCC.0000000000002373CrossRefPubMed

798.

Kido T, Iwagami M, Yasunaga H et al (2020) Outcomes of paediatric out-of-hospital cardiac arrest according to hospital characteristic defined by the annual number of paediatric patients with invasive mechanical ventilation: a nationwide study in Japan. Resuscitation 148:49–56. https://doi.org/10.1016/j.resuscitation.2019.12.020CrossRefPubMed

799.

Amagasa S, Kashiura M, Moriya T et al (2019) Relationship between institutional case volume and one-month survival among cases of paediatric out-of-hospital cardiac arrest. Resuscitation 137:161–167. https://doi.org/10.1016/j.resuscitation.2019.02.021CrossRefPubMed

800.

Gupta P, Tang X, Gall CM, Lauer C, Rice TB, Wetzel RC (2014) Epidemiology and outcomes of in-hospital cardiac arrest in critically ill children across hospitals of varied center volume: a multi-center analysis. Resuscitation 85(11):1473–1479. https://doi.org/10.1016/j.resuscitation.2014.07.016CrossRefPubMed

801.

Stub D, Nichol G (2012) Hospital care after resuscitation from out-of-hospital cardiac arrest: the emperor’s new clothes? Resuscitation 83(7):793–794. https://doi.org/10.1016/j.resuscitation.2012.03.034CrossRefPubMed

802.

Topjian AA, Telford R, Holubkov R et al (2019) The association of early post-resuscitation hypotension with discharge survival following targeted temperature management for pediatric in-hospital cardiac arrest. Resuscitation 141:24–34. https://doi.org/10.1016/j.resuscitation.2019.05.032CrossRefPubMedPubMedCentral

803.

Laverriere EK, Polansky M, French B, Nadkarni VM, Berg RA, Topjian AA (2020) Association of duration of hypotension with survival after pediatric cardiac arrest. Pediatr Crit Care Med 21(2):143–149. https://doi.org/10.1097/PCC.0000000000002119CrossRefPubMed

804.

Topjian AA, Sutton RM, Reeder RW et al (2019) The association of immediate post cardiac arrest diastolic hypertension and survival following pediatric cardiac arrest. Resuscitation 141:88–95. https://doi.org/10.1016/j.resuscitation.2019.05.033CrossRefPubMedPubMedCentral

805.

Topjian AA, Telford R, Holubkov R et al (2018) Association of early postresuscitation hypotension with survival to discharge after targeted temperature management for pediatric out-of-hospital cardiac arrest: secondary analysis of a randomized clinical trial. JAMA Pediatr 172(2):143–153. https://doi.org/10.1001/jamapediatrics.2017.4043CrossRefPubMedPubMedCentral

806.

Lopez-Herce J, del Castillo J, Matamoros M et al (2014) Post return of spontaneous circulation factors associated with mortality in pediatric in-hospital cardiac arrest: a prospective multicenter multinational observational study. Crit Care 18(6):607. https://doi.org/10.1186/s13054-014-0607-9CrossRefPubMedPubMedCentral

Springerpflege

Lebensrettende Maßnahmen bei Kindern (Paediatric Life Support, PLS)

Leitlinien des European Resuscitation Council 2021

Zusammenfassung

Weitere Artikel der Ausgabe 4/2021

Kurzfassung

Lehre in der Reanimation

Ethik der Reanimation und Entscheidungen am Lebensende

Versorgung und Reanimation des Neugeborenen nach der Geburt

Erweiterte lebensrettende Maßnahmen für Erwachsene

Die neuen Reanimationsleitlinien 2021 in der deutschen Übersetzung – die BIG-FIVE-Überlebensstrategien gewinnen deutlich an Bedeutung