nach oben

Zeitschrift für Gerontologie und Geriatrie

Erschienen in:

12.07.2023 | Themenschwerpunkt

Frailty-Phänotyp und Risikofaktor gestörter Schlaf

verfasst von: Prof. Dr. med. Helmut Frohnhofen, Dr. med. Carla Stenmanns, Dr. rer. nat. Janine Gronewold, Prof. Dr. Geert Mayer

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 7/2023

Einloggen, um Zugang zu erhalten

Zusammenfassung

Frailty hat – unabhängig von der Art ihrer Operationalisierung – erhebliche negative Folgen für den Betroffenen und die Solidargemeinschaft. Auch wenn eine allgemein akzeptierte Definition von Frailty noch fehlt, besteht an der Existenz dieses Phänomens kein Zweifel. Pathophysiologisch wird ein dysfunktionales Zusammenspiel komplexer Systeme diskutiert. Therapeutische Konzepte zeigen, dass Frailty ein dynamischer Zustand ist, der verbessert werden kann. Die pathophysiologischen Charakteristika von Frailty und gestörtem Schlaf weisen zahlreiche Gemeinsamkeiten auf. Zudem findet sich das Frailty häufiger bei Schlafgestörten. Da die Mehrzahl der Schlafstörungen gut behandelbar ist, sollte ein Screening auf Schlafstörungen in ein umfassendes Konzept zum Management von Frailty integriert werden.

Vorheriger Artikel Observed daytime sleepiness in in-hospital geriatric patients and risk of falls

Nächster Artikel Schlaf und Demenz

Ashar FN, Moes A, Moore AZ et al (2015) Association of mitochondrial DNA levels with frailty and all-cause mortality. J Mol Med 93:177–186. https://doi.org/10.1007/s00109-014-1233-3CrossRefPubMed

Boucher EL, Gan JM, Rothwell PM et al (2023) Prevalence and outcomes of frailty in unplanned hospital admissions: a systematic review and meta-analysis of hospital-wide and general (internal) medicine cohorts. EClinicalMedicine 59:101947. https://doi.org/10.1016/j.eclinm.2023.101947CrossRefPubMedPubMedCentral

Bruno RR, Wernly B, Bagshaw SM et al (2023) The clinical frailty scale for mortality prediction of old acutely admitted intensive care patients: a meta-analysis of individual patient-level data. Ann Intensive Care 13:37. https://doi.org/10.1186/s13613-023-01132-xCrossRefPubMedPubMedCentral

Cesari M, Nobili A, Vitale G (2016) Frailty and sarcopenia: from theory to clinical implementation and public health relevance. Eur J Intern Med 35:1–9. https://doi.org/10.1016/j.ejim.2016.07.021CrossRefPubMed

Checa-López M, Oviedo-Briones M, Pardo-Gómez A et al (2019) FRAILTOOLS study protocol: a comprehensive validation of frailty assessment tools to screen and diagnose frailty in different clinical and social settings and to provide instruments for integrated care in older adults. BMC Geriatr 19:86. https://doi.org/10.1186/s12877-019-1042-1CrossRefPubMedPubMedCentral

Elmasry A, Lindberg E, Hedner J et al (2002) Obstructive sleep apnoea and urine catecholamines in hypertensive males: a population-based study. Eur Respir J 19:511–517. https://doi.org/10.1183/09031936.02.00106402CrossRefPubMed

Fernandez-Mendoza J, Baker JH, Vgontzas AN et al (2017) Insomnia symptoms with objective short sleep duration are associated with systemic inflammation in adolescents. Brain Behav Immun 61:110–116. https://doi.org/10.1016/j.bbi.2016.12.026CrossRefPubMed

Ferrucci L, Fabbri E (2018) Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol 15:505–522. https://doi.org/10.1038/s41569-018-0064-2CrossRefPubMedPubMedCentral

Fontvieille AM, Rising R, Spraul M et al (1994) Relationship between sleep stages and metabolic rate in humans. Am J Physiol 267:E732–7. https://doi.org/10.1152/ajpendo.1994.267.5.E732CrossRefPubMed

10.

Fried LP, Cohen AA, Xue Q‑L et al (2021) The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nat Aging 1:36–46. https://doi.org/10.1038/s43587-020-00017-zCrossRefPubMedPubMedCentral

11.

Fried LP, Tangen CM, Walston J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–56. https://doi.org/10.1093/gerona/56.3.m146CrossRefPubMed

12.

Fried LP, Xue Q‑L, Cappola AR et al (2009) Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci 64:1049–1057. https://doi.org/10.1093/gerona/glp076CrossRefPubMed

13.

Garby L, Kurzer MS, Lammert O et al (1987) Energy expenditure during sleep in men and women: evaporative and sensible heat losses. Hum Nutr Clin Nutr 41:225–233PubMed

14.

Gerlach M, Sanner B (2017) Leitlinien in der Praxis: Die neue S3-Leitlinie „Nicht erholsamer Schlaf/Schlafstörungen“ – Kapitel „Schlafbezogene Atmungsstörungen“. Laryngorhinootologie 96:685–690. https://doi.org/10.1055/s-0043-114750CrossRefPubMed

15.

Ghachem A, Fried LP, Legault V et al (2021) Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems. Biogerontology 22:63–79. https://doi.org/10.1007/s10522-020-09903-wCrossRefPubMed

16.

Harsch IA, Schahin SP, Radespiel-Tröger M et al (2004) Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. Am J Respir Crit Care Med 169:156–162. https://doi.org/10.1164/rccm.200302-206OCCrossRefPubMed

17.

Hedner J, Darpö B, Ejnell H et al (1995) Reduction in sympathetic activity after long-term CPAP treatment in sleep apnoea: cardiovascular implications. Eur Respir J 8:222–229. https://doi.org/10.1183/09031936.95.08020222CrossRefPubMed

18.

Ip MSM, Lam B, Ng MMT et al (2002) Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 165:670–676. https://doi.org/10.1164/ajrccm.165.5.2103001CrossRefPubMed

19.

Johar H, Emeny RT, Bidlingmaier M et al (2014) Blunted diurnal cortisol pattern is associated with frailty: a cross-sectional study of 745 participants aged 65 to 90 years. J Clin Endocrinol Metab 99:E464–8. https://doi.org/10.1210/jc.2013-3079CrossRefPubMed

20.

Kritikou I, Basta M, Vgontzas AN et al (2016) Sleep apnoea and the hypothalamic-pituitary-adrenal axis in men and women: effects of continuous positive airway pressure. Eur Respir J 47:531–540. https://doi.org/10.1183/13993003.00319-2015CrossRefPubMed

21.

Kwan RYC, Cheung DSK, Lo SKL et al (2019) Frailty and its association with the Mediterranean diet, life-space, and social participation in community-dwelling older people. Geriatr Nurs 40:320–326. https://doi.org/10.1016/j.gerinurse.2018.12.011CrossRefPubMed

22.

Mehkri Y, Chakravarti S, Sharaf R et al (2023) The mFI‑5 score predicts return to the operating room for patients undergoing posterior spinal fusion for traumatic spine injury. World Neurosurg. https://doi.org/10.1016/j.wneu.2023.04.095CrossRefPubMed

23.

Meier-Ewert HK, Ridker PM, Rifai N et al (2004) Effect of sleep loss on C‑reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol 43:678–683. https://doi.org/10.1016/j.jacc.2003.07.050CrossRefPubMed

24.

Mitnitski AB, Mogilner AJ, Rockwood K (2001) Accumulation of deficits as a proxy measure of aging. TheScientificWorldJOURNAL 1:323–336. https://doi.org/10.1100/tsw.2001.58CrossRefPubMedPubMedCentral

25.

Moreno-Tamayo K, Manrique-Espinoza B, Morales-Carmona E et al (2021) Sleep duration and incident frailty: the rural frailty study. BMC Geriatr 21:368. https://doi.org/10.1186/s12877-021-02272-0CrossRefPubMedPubMedCentral

26.

Nardi R, Scanelli G, Corrao S et al (2007) Co-morbidity does not reflect complexity in internal medicine patients. Eur J Intern Med 18:359–368. https://doi.org/10.1016/j.ejim.2007.05.002CrossRefPubMed

27.

Ofori-Asenso R, Chin KL, Mazidi M et al (2019) Global incidence of frailty and prefrailty among community-dwelling older adults: a systematic review and meta-analysis. JAMA Netw Open 2:e198398. https://doi.org/10.1001/jamanetworkopen.2019.8398CrossRefPubMedPubMedCentral

28.

Punjabi NM, Beamer BA (2007) C‑reactive protein is associated with sleep disordered breathing independent of adiposity. Sleep 30:29–34. https://doi.org/10.1093/sleep/30.1.29CrossRefPubMed

29.

Punjabi NM, Sorkin JD, Katzel LI et al (2002) Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med 165:677–682. https://doi.org/10.1164/ajrccm.165.5.2104087CrossRefPubMed

30.

Ramanathan L, Gulyani S, Nienhuis R et al (2002) Sleep deprivation decreases superoxide dismutase activity in rat hippocampus and brainstem. Neuroreport 13:1387–1390. https://doi.org/10.1097/00001756-200208070-00007CrossRefPubMedPubMedCentral

31.

Riemann D, Baglioni C, Bassetti C et al (2017) European guideline for the diagnosis and treatment of insomnia. J Sleep Res 26:675–700. https://doi.org/10.1111/jsr.12594CrossRefPubMed

32.

Rockwood K, Song X, MacKnight C et al (2005) A global clinical measure of fitness and frailty in elderly people. CMAJ 173:489–495. https://doi.org/10.1503/cmaj.050051CrossRefPubMedPubMedCentral

33.

Sapin E, Peyron C, Roche F et al (2015) Chronic intermittent hypoxia induces chronic low-grade neuroinflammation in the dorsal hippocampus of mice. Sleep 38:1537–1546. https://doi.org/10.5665/sleep.5042CrossRefPubMedPubMedCentral

34.

Sateia MJ (2014) International classification of sleep disorders-third edition: highlights and modifications. Chest 146:1387–1394. https://doi.org/10.1378/chest.14-0970CrossRefPubMed

35.

Searle SD, Mitnitski A, Gahbauer EA et al (2008) A standard procedure for creating a frailty index. BMC Geriatr 8:24. https://doi.org/10.1186/1471-2318-8-24CrossRefPubMedPubMedCentral

36.

Siegel JM (2003) Why we sleep. Sci Am 289:92–97. https://doi.org/10.1038/scientificamerican1103-92CrossRefPubMedPubMedCentral

37.

Spiegel K, Knutson K, Leproult R et al (2005) Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes. J Appl Physiol 99:2008–2019. https://doi.org/10.1152/japplphysiol.00660.2005CrossRefPubMed

38.

Spiegel K, Leproult R, L’hermite-Balériaux M et al (2004) Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab 89:5762–5771. https://doi.org/10.1210/jc.2004-1003CrossRefPubMed

39.

Sun X, Liu W, Gao Y et al (2023) Comparative effectiveness of non-pharmacological interventions for frailty: a systematic review and network meta-analysis. Age Ageing. https://doi.org/10.1093/ageing/afad004CrossRefPubMedPubMedCentral

40.

Theou O, Brothers TD, Mitnitski A et al (2013) Operationalization of frailty using eight commonly used scales and comparison of their ability to predict all-cause mortality. J Am Geriatr Soc 61:1537–1551. https://doi.org/10.1111/jgs.12420CrossRefPubMed

41.

Van Cauter E, Holmback U, Knutson K et al (2007) Impact of sleep and sleep loss on neuroendocrine and metabolic function. Horm Res 67(1):2–9. https://doi.org/10.1159/000097543CrossRefPubMed

42.

Vgontzas AN, Kales A (1999) Sleep and its disorders. Annu Rev Med 50:387–400. https://doi.org/10.1146/annurev.med.50.1.387CrossRefPubMed

43.

Vgontzas AN, Papanicolaou DA, Bixler EO et al (2000) Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 85:1151–1158. https://doi.org/10.1210/jcem.85.3.6484CrossRefPubMed

44.

Vgontzas AN, Tsigos C, Bixler EO et al (1998) Chronic insomnia and activity of the stress system: a preliminary study. J Psychosom Res 45:21–31. https://doi.org/10.1016/s0022-3999(97)00302-4CrossRefPubMed

45.

Walston JD, Bandeen-Roche K (2015) Frailty: a tale of two concepts. BMC Med 13:185. https://doi.org/10.1186/s12916-015-0420-6CrossRefPubMedPubMedCentral

46.

West SD, Nicoll DJ, Wallace TM et al (2007) Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes. Thorax 62:969–974. https://doi.org/10.1136/thx.2006.074351CrossRefPubMedPubMedCentral

47.

Zhu Y, Fan J, Lv J et al (2022) Maintaining healthy sleep patterns and frailty transitions: a prospective Chinese study. BMC Med 20:354. https://doi.org/10.1186/s12916-022-02557-0CrossRefPubMedPubMedCentral

Titel: Frailty-Phänotyp und Risikofaktor gestörter Schlaf
verfasst von: Prof. Dr. med. Helmut Frohnhofen
Dr. med. Carla Stenmanns
Dr. rer. nat. Janine Gronewold
Prof. Dr. Geert Mayer
Publikationsdatum: 12.07.2023
Verlag: Springer Medizin
Erschienen in: Zeitschrift für Gerontologie und Geriatrie / Ausgabe 7/2023
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI: https://doi.org/10.1007/s00391-023-02219-7

Schlaf und geriatrische Syndrome

Einführung zum Thema

Observed daytime sleepiness in in-hospital geriatric patients and risk of falls

Themenschwerpunkt

Journal Club

Journal Club

Evaluation and intention to use the interactive robotic kitchen system AuRorA in older adults

Open Access
Original Contributions

Delirium and sleep disturbances—A narrative review

Themenschwerpunkt

Akzeptanz psychosozialer Überbrückungsmaßnahmen im Rahmen demenzieller Erkrankungen

Open Access
Originalien

Springerpflege

Frailty-Phänotyp und Risikofaktor gestörter Schlaf

Zusammenfassung

Weitere Artikel der Ausgabe 7/2023

Schlaf und geriatrische Syndrome

Observed daytime sleepiness in in-hospital geriatric patients and risk of falls

Journal Club

Evaluation and intention to use the interactive robotic kitchen system AuRorA in older adults

Delirium and sleep disturbances—A narrative review

Akzeptanz psychosozialer Überbrückungsmaßnahmen im Rahmen demenzieller Erkrankungen

Springerpflege

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Schlaf und geriatrische Syndrome

Observed daytime sleepiness in in-hospital geriatric patients and risk of falls

Journal Club

Evaluation and intention to use the interactive robotic kitchen system AuRorA in older adults

Delirium and sleep disturbances—A narrative review

Akzeptanz psychosozialer Überbrückungsmaßnahmen im Rahmen demenzieller Erkrankungen