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2016 | OriginalPaper | Buchkapitel

6. Embryologie und Teratologie

verfasst von : Wolfgang E. Paulus

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Im Verlauf der intrauterinen Entwicklung durchläuft die Frucht Stadien unterschiedlicher Empfindlichkeit gegenüber äußeren Einflüssen. Während sich die Reaktion auf schädigende Agenzien in den ersten beiden Wochen nach Konzeption weitgehend auf die Alternativen vollständige Heilung des Defekts oder Absterben beschränkt, können Einflüsse von Woche 3–8 nach Konzeption zu Störungen der Organdifferenzierung und damit zu Fehlbildungen führen.

In der Fetalperiode stehen Wachstums- und Funktionsstörungen durch exogene Noxen im Vordergrund.

Seit nach Einnahme von Thalidomid ca. 10.000 Kinder mit schweren Gliedmaßendefekten geboren wurden, herrscht bei pharmazeutischer Industrie, Ärzten und Patientinnen berechtigte Vorsicht gegenüber dem Einsatz von Arzneimitteln in der Schwangerschaft. Ein therapeutischer Nihilismus bei chronisch kranken Schwangeren kann jedoch zu einer dramatischen Verschlechterung der Grunderkrankung und damit zu einer erheblichen Gefährdung der fetalen Entwicklung führen.

Vorheriges Kapitel Ungewollte Schwangerschaft

Nächstes Kapitel Pränatale Diagnostik: Molekularbiologische Methoden

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Titel: Embryologie und Teratologie
verfasst von: Wolfgang E. Paulus
Verlag: Springer Berlin Heidelberg
Buch: Die Geburtshilfe
Print ISBN: 978-3-662-45063-5

Electronic ISBN: 978-3-662-45064-2

Copyright-Jahr: 2016
DOI: https://doi.org/10.1007/978-3-662-45064-2_6

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Zusammenfassung

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